Báo cáo y học: "New approaches to combating antimicrobial drug resistance" pps

... sensitive to the actions of the drug; (3) enzymatic destruction or modification of the drug either in the cytoplasm, for example, the inactivation of gentamicin by aminoglycoside-modifying enzymes, ... removal of drugs from the periplasm or cytoplasm by efflux pumps. In some cases, drug resistance is due to a combination of these mechanisms. Drugs Porin Drug target Periplasm Cell...

Ngày tải lên: 14/08/2014, 16:20

... report New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18–23, San Francisco David J Hele Respiratory Pharmacology Group, Cardiothoracic Surgery, Imperial ... high local anti-inflammatory activity. The anti-inflammatory effi- cacy of Ciclesonide in these studies was similar to that produced by Fluticasone but with an improved safety prof...

Ngày tải lên: 12/08/2014, 18:20

... proct'ss only requires a yes/no answer to gramnmtic;dity, any parsing or recognition sys- l.e;,t f,,r simple sentences can be used. We can now specify a l,redicate lindcandi(lates(X Y SI $2) ... redundant if they have the form (uv, uw) or (uv, zv), in which case - they may be replaced by the pairs (v, w) ~ad (u, z) respectively. • Ia Goodall's definition an...

Ngày tải lên: 31/03/2014, 17:20

... protein-coupled receptor; receptor (fMLP-R26) binds bacterial N-formyl-methionyl peptides X91257 SERRS Seryl-tRNA synthetase 111.8 59.2 1.9 Cytosolic seryl-tRNA synthetase; class II aminoacyl tRNA synthetase, ... oxide synthase. Adenylate cyclase, 3.4 6.4 1.9 Adenylate cyclase (type 7), an ATP-pyrophosphate lyase; type VII converts ATP to cAMP C. Genes expressed in active untreated patients...

Ngày tải lên: 09/08/2014, 01:23

... pathway and cytolysis of type 1 and type 2 alveolar epithelial cells and helps in the dissemination of M. tuberculosis [20,70]. The released bacilli multiply extracellularly, are phago- cytosed by ... mediated immunity-based assays (IGRAs) has al so been developed by using flow cytometry [158]. Although flow cytometric approach uses smaller blood volume (<1 ml), the assay will have limited...

Ngày tải lên: 12/08/2014, 13:22

... genomics to classify cancers so far have been made with leukemia and lymphoma. A study of myelogenous and lymphocytic leukemias at Harvard with gene arrays demonstrated the ability to find distinguishing ... the Cancer Genome Anatomy Project [2], sponsored by the biotechnology industry and by government, have probably sequenced ESTs for nearly all of the estimated 100000–120000 total huma...

Ngày tải lên: 12/08/2014, 18:20

... pulmonary hyper- tension; PGI 2 = prostacyclin; PGIS = prostacyclin synthase; PH = pulmonary hypertension; PPAR = peroxisome proliferator-activated receptor; PPH = primary pulmonary hypertension; ... demonstrated, by in situ hybridization, western analysis and immunohis- tochemistry, that patients with PPH have decreased lung tissue prostacyclin synthase (PGIS) [7]. A comprehensive histochemi...

Ngày tải lên: 12/08/2014, 18:20

... most abundant topology, followed by Lys63 and Lys11 chains and the less frequent linkages through Lys33, Lys27, Lys6, and Lys29 (the latter is detected only in combination with Lys33 linkage) ... chromatography in order to purify ubiquitinated proteins from yeast cells expressing 6xHis-ubiquitin. Remarkably, by profiling a yeast strain with a mutation in the proteasomal ubiquitin receptor ....

Ngày tải lên: 14/08/2014, 14:22

... Prinsen E, Sundaresan V, Murray JA: AArraa bbiiddooppssiiss CCYYCCDD33 DD ttyyppee ccyycclliinnss lliinnkk cceellll pprroolliiffeerraattiioonn aanndd eennddooccyycclleess aanndd aarree rraattee ... Miyoshi K, Ahn BO, Kawakatsu T, Ito Y, Itoh J, Nagato Y, Kurata N: PPLLAASSTTOOCCHHRROONN11 ,, aa ttiimmeekkeeeeppeerr ooff lleeaaff iinniittiiaattiioonn iinn rriiccee,, eennccooddeess ccyyttoo...

Ngày tải lên: 14/08/2014, 20:22

... from basic cell biology to the use of yeast for industrial purposes and translational research. Here, I summarize a few highlights related to systems and synthetic biology, yeasts as model organisms ... posttranscriptional regulatory process controlled by iron deficiency. Target of rapamycin (TOR) is the central component of a conserved eukaryotic signaling pathway that regulates cel...

Ngày tải lên: 09/08/2014, 20:20