Báo cáo y học: "When Genome Biology was launched in 2000" doc

Ngày tải lên: 14/08/2014, 16:20

... they fell into two distinct clusters, raising the interesting possibility that there might be two distinct major classes of intron. Interest in epigenetics is also increasing, and although assays for ... pathways by finding patterns of interactions similar to known pathways. With large amounts of data safely stored and made accessible, the future of high- throughput biology has to lie in...

Ngày tải lên: 14/08/2014, 16:21

... This year’s HGM was the tenth anniversary meeting, with approximately 500 presentations covering a wide variety of work on the human genome. In his opening remarks, the president of HUGO, Yoshiyuki ... LTA4 hydrolase, an enzyme involved in leukotriene B4 biosynthesis, is associated with myocardial infarction (MI), and that LTB4 upregulation by ionomycin stimulation of neutrophils is hi...

Ngày tải lên: 14/08/2014, 14:21

... during intestinal tumorigenesis may, in part, act through upregu- lation of b-catenin, increasing intest inal b-cat enin signal- ing and cell proliferation. Also, increase in small-intestinal mucosa ... temporally coordinated physiology [23-25]. Indirect synchronization is achieved by controlling d aily activity-rest cycles and, as a conse- quence, feeding time. Feeding (or starving) cycl...

Ngày tải lên: 10/08/2014, 09:20

... mimicry [8] to toll-like receptor binding [9] to autoantibody immune complexes stimulating interferon, a key cytokine in the pathogenesis of SLE [10].  us, autoantibodies are especially useful ... useful if they are helpful in eliminating or establishing the diagnosis, parsing patients in terms of prognosis or risk, or elucidating the underlying mecha- nisms of the disease. In...

Ngày tải lên: 12/08/2014, 12:20

... extracellular signals. Interestingly, myogenin was significantly less efficient than MyoD or Myf5 in initiating endogenous muscle gene expression. Domain-swap experiments between MyoD and myogenin, both members of the myogenic ... lysozyme gene in myeloid cells [67], and for the b-globin gene in erythrocytes [68]. Priming by SWI/SNF complexes may even apply to the myogenic determination...

Ngày tải lên: 31/03/2014, 21:21

... optimize the binder and nonbinder PWMs by minimizing the total information entropy of the binders while augmenting the nonbinder sequence set by taking both strands of the validated nonbind- ing loci. ... by rendering good binding sites inactive. In our strategy, the approximately 38,000 high-likelihood ER-binding sites were identified using a training set biased to the 5' cis-regulato...

Ngày tải lên: 14/08/2014, 17:22

... of psy- chotherapy in psychopathy was assessed in a meta-analy- sis by Salekin et al. [65]. They analysed 42 interventional studies for individuals classified as psychopathic (unfor- tunately, ... when executing a task by self as well as while observing it being executed by another) was central in defining theories on neural pathways of empa- thy [11]. Firstly, this observation was...

Ngày tải lên: 08/08/2014, 23:21

... large insertions ranging from 15 to 57 amino acids were identified in 14 conserved proteins in O. bayeri (O- sialoglycoprotein endopeptidase, 3-hydroxy-3-methylglu- taryl CoA reductase, 3-ketoacyl ... caused by the potential presence of introns, with introns previously reported in Enc. cuniculi [25] searched for manually. Gene density in the O. bayeri genome was determined by anno...

Ngày tải lên: 09/08/2014, 20:20

... found online at http://genomebiology.com/2009/10/10/R118 http://genomebiology.com/2009/10/10/R118 Genome Biology 2009, Volume 10, Issue 10, Article R118 Conrad et al. R118.10 Genome Biology 2009, ... respective endpoint strain and wild type. The kdtA single mutant was unable to grow without amino acid supplementation. http://genomebiology.com/2009/10/10/R118 Genome Biology 200...

Ngày tải lên: 09/08/2014, 20:20