Báo cáo y học: "The design of transcription-factor binding sites is affected by combinatorial regulation" pps

... BarkaiVolume 6, Issue 12, Article R103 Research The design of transcription-factor binding sites is affected by combinatorial regulation Yonatan Bilu * and Naama Barkai *† Addresses: * Department of Molecular ... number of binding sites, and the gene promoters that are most amenable to the addition or deletion of binding sites. Based on this analysis, we sugges...

Ngày tải lên: 14/08/2014, 15:20

... ashkan.karimi@surgery.ufl.edu 2 University of Florida, Division of Thoracic and Cardiovascular Surgery, Gainesville, FL, USA Full list of author information is available at the end of the article Amirghofran ... estimated Qp/Qs ratio of 2.3. Since the ASD did not have enough rim inferiorly to be closed by device, she was scheduled for surgical closure. Cardiopulmonary bypass was...

Ngày tải lên: 10/08/2014, 09:21

... had no symptom of cys- titis, lupus enteritis and lupus cystitis often coexist, sug- gesting that the pathological process may be closely associated [15]. We could taper steroid gradually without inducing ... 5 of 5 2. Byun JY, Ha HK, Yu SY, Min JK, Park SH, Kim HY, Chun KA, Choi KH, Ko BH, Shinn KS: CT features of systemic lupus erythematosus in patients with acute abdominal pain: em...

Ngày tải lên: 11/08/2014, 12:20

... accurately the citations to individually published arti- cles. Today, many electronic tools (e.g. ISI Web of Science, Scopus, Google Scholar) exist that can accomplish this task facilely and reliably. ... create lists of "highly cited" scientists in various fields (e.g. http://isihighly cited.com/; highly cited in immunology, highly cited in microbiology, highly cited in molecul...

Ngày tải lên: 12/08/2014, 23:22

... mortality outcomes graphically, and more easily and rapidly than is possible using the quarterly standardized mortality ratios received from an ICU national audit programme, as already exists in ... accessibility to a nonstatistical audience outweigh potential disadvantages. Commentary The value of monitoring outcomes should be measured by the appropriateness of the response Timothy P...

Ngày tải lên: 12/08/2014, 23:23

... beyond? The continued inability of studies to demonstrate the efficacy of CCOS and a complete lack of evidence for cost-effectiveness is worrying. A recent guideline by the National Institute for ... feel able to recommend the use of early warning scoring systems but was unable to identify a particular system or cutoff points due to the lack of evidence of accuracy for these s...

Ngày tải lên: 13/08/2014, 10:20

... hyperphosphorylated form, by a positive effect caused by accumulation of the hypophosphorylated form or by a combination of the two mechanisms, in keeping with the self-regulation of the Rb gene by its own gene ... present in distinct phosphorylation states depending on the phase of the cell cycle [10,11]: it is nonphosphorylated when newly synthesized; hypophos- phorylated...

Ngày tải lên: 16/03/2014, 23:20

... fold is part of the ureohydrolase superfamily, which also includes agmatinase [15,16], histone de-acetylase and acetylpolyamine amidohydrolase [17]. Agmatine is formed by decarboxylation of arginine ... stability. It was previously reported that removing Mn 2+ , either by dialysis and chelation with EDTA, or by mutagenesis of Mn 2+ co-ordinating residues in the active site, o...

Ngày tải lên: 29/03/2014, 23:20

... µ n−1 (G) is 0 if and only if G is disconnected. Thus µ n−1 (G) is popularly known as the algebraic connectivity of G and is usually denoted by α(G). Recently, the algebraic connectivity ha s received ... be the adjacency matrix and the diagonal matrix of vertex degrees of G, respectively. The Laplacian matrix of G is defined a s L(G) = D(G)−A(G). It is ea sy to see that...

Ngày tải lên: 08/08/2014, 12:23

... interaction sites identified by PARalyzer with baseline methods, in terms of the presence of putative binding motifs normalized to the total size of the identified interaction sites. Initial analysis of PAR-CLIP ... context of multiple motif analysis of AGO data sets we take advantage of the well-established mechanism of miRNA-based gene regulation [20,21], which is l...

Ngày tải lên: 09/08/2014, 23:20