Báo cáo y học: "Predicting the sites of metastases" pot

... but the ability to focus the treatment on patients most at risk would be of great utility. Altogether, the emerging ability to identify tissue- tropic biomarkers and the maturing of the field of ... outcome. An understanding of the mechanism of the specificity of tumor tropism, or at least the ability to predict for an individual patient their likely site of meta...

Ngày tải lên: 14/08/2014, 15:20

... costs for therapy, there is a strong need to make predictions on success before the start of therapy. In the current issue of Arthritis Research & Therapy, Hueber and colleagues become the first ... therapy Editorial Predicting the future of anti-tumor necrosis factor therapy Cornelis L Verweij Division of Inflammatory Disease Profiling, Department of Pathology and Rheum...

Ngày tải lên: 09/08/2014, 14:21

... n3 ha-1yr-1 for the typical site. The 95% Cl for the mean GYC for the site ranged from ±0.7 for the typical site to ±2.4 m3 ha-1yr-1 for the high yielding site. The range ... were predicted from the model for 3, quite differ- ent, hypothetical sites. Two of these are extreme sites, and the third is more typical (table III). The...

Ngày tải lên: 08/08/2014, 19:21

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certain...

Ngày tải lên: 25/10/2012, 10:39

... indepen- dent of each other. Fluency was judged directly by the assessors, while adequacy was meant to assess the content of the sentence compared to a human gold-standard. Yet, the assessments of the ... 80%. The performance of pairwise comparison of fluency is also very high—over 90% for a multi-layer perceptron classifier. We also test the hypothesis that the learne...

Ngày tải lên: 22/02/2014, 02:20

... particularly attempted to investigate the functional importance of the Gly pair, located in the vicinity of the active site of the cold adapted enzyme and to study its potential role in the establishment ... although the HGGG loop was a critical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attribut...

Ngày tải lên: 22/02/2014, 04:20

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A (Figs 2–4). Interestingly, the preservation of the tertiary structure coincides with the ... hydro- chloride (GdnHCl), urea or elevated temperatures, they destroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the...

Ngày tải lên: 22/02/2014, 07:20

... when studying the catalytic efficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-type enzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functions carried out by E301 in the wild-type enzyme [22]. In this c...

Ngày tải lên: 31/03/2014, 08:20

... complement of chromosomes. The fidelity of chromosome transmission is enhanced not only by the geometry of stable centromere–MT interac- tions, but also by the action of a centromere-based regulatory system ... way, the critical connections that hold sisters together from S phase through early mitosis are literally cut by Ômolecular scissorsÕ in the form of Esp1/separase at...

Ngày tải lên: 31/03/2014, 21:21

... for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns with the use of INCs are the ... for the clinician to be comfortable with the- side effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns with the...

Ngày tải lên: 08/08/2014, 21:20