... for its LEMdomain (LAP2, emer in, MAN-1), which interacts withthe DNA-binding protein BAF-1 in human and C. ele-gans, illustrating one way that LEM-2 may interact withchromatin in vivo [13,19].Our ... membraneThedatapresentedabovedemonstratethebindingofLEM-2 to broad domains of chromosome arms. Wenext examined the pattern of LEM-2 binding withinthese domains mo re closely. We found that, withinLEM-2 domains, there are many interruptions ... atransmembrane protein localized to the inner nuclearmembrane, with homologs in a wide variety of organ-isms, including yeast, mouse, human, and C. elegans [11-16]. In human and C. elegans, LEM-2 interacts...