Báo cáo y học: "Virus-host interactions: new insights from the small RNA world" pot

... [16]. The viral miRNA may thus reduce the susceptibility of the virus to the host immune system. Viral small RNAs Bennasser and co-workers [17] now report that HIV triggers the RNA- silencing system ... Viral RNA molecules may also interfere with the RNA- silencing machinery. The adenoviral noncoding RNA VA1 inhibits RNA silencing, possibly by blocking the nuclear e...

Ngày tải lên: 14/08/2014, 15:20

... especially in the solitary library (Figure S4b in Additional data file 3). Their features indicated that these 26-29-mer small RNAs might be of the piRNA class of small RNAs. Therefore, we analyzed the ... study. YW performed all the bioin- formatic analysis except target prediction of miRNAs. SC pro- vided help to analyze piRNA-like small RNAs. PY predicted targets of miRNAs an...

Ngày tải lên: 14/08/2014, 21:20

... Genomic DNA from MCC tumors was digested with two restriction enzymes and analyzed by Southern hybridization using a MCPyV DNA probe. From the observed banding patterns, five of the eight MCPyV-positive ... for MCPyV and found that seven were strongly positive for MCPyV DNA by PCR and an additional tumor was weakly positive. The strength of the PCR signals raised the question of...

Ngày tải lên: 14/08/2014, 08:21

... providing some reassurance as to the accuracy of the genomic approaches. The sensitivity of the microarray method is evident from the fact that among the targets there are genes that, in normal ... long way downstream from the direct actions of Ubx. The safest way to identify direct targets is to characterize the cis-regulatory elements that mediate their Hox response....

Ngày tải lên: 14/08/2014, 18:20

... 269) 3143 The origin of these cytosolic oligosaccharides is not known. They could be synthesized in the cytosol by glycosyltransferases which add glucosyl or galactosyl resi- dues to the free ... any of the reactions involved in their biosynthesis represent excellent potential target sites for chemotherapeutic intervention in tuberculosis. However, in mycobacteria there may be as many...

Ngày tải lên: 22/02/2014, 07:20

... calculated from the spectral parameter used to follow denaturation (y) prior to the minimization procedure, according to the expression: F U ¼ y À y N Þ= y U À y N Þð6Þ where y N ¼ a 1 + a 2 T and y U ¼ ... peroxidases can be used in the synthesis of polyaniline in the presence of hydrogen peroxide as a reduc- ting substrate and sulfonated polystyrene and poly(vinyl- pho...

Ngày tải lên: 31/03/2014, 15:20

... isolation of new coumarin, 6-hydroxy-7-methoxy-10 4 methyl coumarin (2) and 6-hydroxy-7-methoxy coumarin (3); this is the first time they have been isolated from this plant. The structures of the compounds ... per the protocol specified. The anti-inflammatory activity of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method. The...

Ngày tải lên: 20/06/2014, 20:20

... specified. The anti-inflammatory activity of the synthesized compounds was carried out using the carrageenan-induced rat paw edema method. The anti-inflammatory activity data for the compounds ... between the right and left hind paw volumes in the treated group from the difference in the control group and dividing it by the difference in the control group. The an...

Ngày tải lên: 21/06/2014, 17:20

... that the former con- tains novel amino acids and domain structures typically derived from intron fusion. These alterations may subsequently alter the functionality of the ASV as compared with the ... Bioinformatics analyses predict that the majority of human genes undergo alternative splicing, generating proteins – many of which may have regulatory functions. The objective of t...

Ngày tải lên: 09/08/2014, 10:23

... by the greater than 99% SNP calling accuracy and especially the ability to call correctly most het- erozygous sites. The solution hybridization-based method is clearly dependent on the ability ... roughly an equal number of nonsynony- mous variants in the 622 genes, with one in every five genes having a heterozygote and one in every 10 having a homozy- gote nonsynonymous variant. Mo...

Ngày tải lên: 09/08/2014, 20:20