Báo cáo y học: "Close encounters between active genes in the nucleus" pdf

... of the other four genes in 40-60% of erythroid cells, seemingly an extraordinarily high percentage for random intrachromosome folding. The close proximity between several of these genes in the ... encoding the cytokine interferon ␥ (IFN␥) and specific sequences in the T H 2 locus, including the genes encoding interleukin 5 (IL5) and the DNA-repair protein Rad50 as...

Ngày tải lên: 14/08/2014, 15:20

... currently the most important cytokine in the pathogenesis of RA, the mechanisms involved in the perpetuation of TNF production in the rheumatoid syn- ovium are not yet fully understood [1,8]. In this ... supporting the importance of intercellular contacts in the pathogenic mechanisms underlying RA. Indeed, the importance of these cell-cell interactions in the syn...

Ngày tải lên: 09/08/2014, 08:22

... a clinical syndrome caused by the deposition of monosodium urate monohydrate crystals into synovial, bursal, and cartilaginous tissue. The underlying metabolic disorder is hyperuricemia. The ... in any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity. In this case, althoug...

Ngày tải lên: 25/10/2012, 10:06

... and consequently the EDTA-IM. Hydroxyproline, hydroxy- lysine and phosphoserine were not detected in WSM, WIM, EDTA-SM and EDTA-IM. The comparison of the amino acid composition of the main peak obtained ... revealed the predominance of two amino acids: alanine (39.2%) and glycine (30%). Interestingly, the proportions are very similar to those found in WSM for alanine and glyci...

Ngày tải lên: 21/02/2014, 01:21

... agonist-induced BRET observed in this study is that the translation of agonist binding to the ATDs of the family C GPCR homodimer into G-protein coupling of the 7TM)7TM moiety is mediated by another ... 2002 Agonist-induced rearrangement of the 7TMs in the CaR homodimer? One of the goals of the present study was to investigate, whether the activating twist in the ATD...

Ngày tải lên: 08/03/2014, 09:20

... that of his- tamine or methacholine, which indicates that these mediators are extremely potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cysteinyl leukotriene receptors ... arachidonic acid, thereby preventing cysteinyl leukotriene synthe- sis (see Figure 1). Blocking arachidonic enzy- matic conversion by the use of 5-lipoxygenase inhibitors does protect aga...

Ngày tải lên: 08/08/2014, 20:23

... 1993;92:644–51. 24. Durham SR, Ying S, Varney VA, et al. Grass pollen immunother- apy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells ... memory IgE production. 1,6 On the other hand, IL-10 induced by specific immunotherapy suppresses IgE and synthesizes IgG4. In vitro studies demonstrate nonana- phyl...

Ngày tải lên: 08/08/2014, 21:20

... (dehydro- genation, hydroxylation, and N-dealkylation), mainly by cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only a minor effect ... of the 27 in the placebo group (48.1%)). The only dif- ference concerned manic relapses (nine in the placebo and six in the aripiprazole group). Again the YMR...

Ngày tải lên: 08/08/2014, 23:21

... pathway that may increase our understanding of psychiatric disorders. The question of whether or not changes in 5-hydroxytryptam- ine (5-HT)-serotonin levels are related to changes in the expression ... radical turning point in the world of psychiatry is rapidly growing. Present diagnostic meth- ods cannot continue to be considered acceptable because they are almost completely bas...

Ngày tải lên: 08/08/2014, 23:21

... compartmentalization in lymphoid tissues under non-inflammatory conditions [2]. Most chemokines play a role in inflammatory conditions by inducing integrin activation, chemotaxis, and angiogenesis. Apart ... distinct receptors [1]. A subset of the chemokine family is active under normal physiological conditions. These so-called homeostatic chemokines are involved in maintaining norm...

Ngày tải lên: 09/08/2014, 01:23