Báo cáo y học: "Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice" ppt

... that the initiating pathway determines a distinctive expression phenotype in tumors. In addition, using proteins as markers of cell phenotypes, we showed that initiating oncogenes determine the developmental ... discussion Mammary tumors in MMTV-Wnt-1 transgenic mice have an expression profile distinct from that seen in mammary tumors induced by MMTV-Neu Compar...

Ngày tải lên: 14/08/2014, 14:22

... to explain these results. They include the types and the sensitivity of the phenotypic parameters analyzed, the role of the studied polymorphisms, and the potential con- tribution of the studied ... the inflammatory process in CF is dominated by a neutrophil influx in the airways, our present findings reporting that CF patients carrying the BclI GG genotype showe...

Ngày tải lên: 12/08/2014, 15:21

... to 36.4% of deaths in SLE. High rates of atherosclerotic vas- cular disease (ASVD) are particularly striking in young women with SLE, normally at low risk. The incidence of myocardial infarction in ... major problem in systemic lupus erythematosus (SLE) and is one of its major causes of death, an observation first made more than 20 years ago by Urowitz [1]. Coronary artery...

Ngày tải lên: 09/08/2014, 01:22

... stoichiometric binding of protease inhibitors to the catalytic site of the activated forms of the enzymes. In the present work, we have measured by flow cytometry the net proteolytic activity in synovial ... either directly or indirectly, the overall balance that results in the NPA found in SF – most probably by secreting proteases, or by inducing the secretion...

Ngày tải lên: 09/08/2014, 08:22

... basis of daily rates. The question thus arises whether other clinical measures could better predict LOS in inpatient psychiatry to find ways of modifying this cost-determining factor. In view of the ... anxiety” . The severity of each symptom was coded by 0 = no symptom/mild symptom severity, and 1 = moderate to strong symptom severity. The severity rating depends on the...

Ngày tải lên: 11/08/2014, 15:22

... 351®175 (inset) coincides with the first peak of the main trace, confirming the identity of this analyte as PGE 2 rather than PGD 2 . Note the difference in scales of the left y- axis (showing ion ... financially supported in part by Boehringer Ingelheim Vetmedica (Alkma ar, The Netherlands). The funding source had no role in data analysis or interpretation, drafti...

Ngày tải lên: 12/08/2014, 17:22

... could reduce hydroxyproline content in lung Hydroxyproline content is an important indicator of lung fibrosis. In this study, no significant differences in the hydroxyproline content of the four treatment ... process of L-TGF- β1 in the early phase of the experimental silicosis. Further- more, silencing expression of CD36 prevented the devel- opment of silicosi...

Ngày tải lên: 12/08/2014, 14:20

... genes in our study appeared in one or more of the lists of genes identified as being involved in immunity in the microbial pathogen studies in adults, and only 8-10% of the genes in our study were ... irrespective of whether they successfully encapsulate the parasitoid, except that the investment in immune responses may incur slight delays in their speed of...

Ngày tải lên: 14/08/2014, 15:20

... Korea 3 Division of Rheumatology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea 4 Department of Orthopedic Surgery, College of Medicine, Kyung Hee University, Seoul, ... three polymorphisms in the ER-α gene (intron 1 T/C, intron 1 A/G and exon 8 G/A) and primary knee OA. Genotypes of the ER-α gene polymorphism were determined by...

Ngày tải lên: 09/08/2014, 01:23

... we kept only the common genes between these two platforms (10,540 genes); we kept 10% of the genes for which the variance was the largest in the training set. In order to identify prognostic gene signatures, ... corresponding signature: where Q is the set of genes in the signature, n Q is the num- ber of genes in Q, x i is the expression of gene i, an...

Ngày tải lên: 09/08/2014, 20:21