Báo cáo y học: "ystems biology approaches in cell signaling research" potx

... In these systems, therefore, inactivating enzymes in MAP kinase cascades have a key role not only in suppressing the level of pathway activity in unstimulated cells and during recovery from stimuli, ... of EGF-stimulated cells both in culture, as assayed by acquisi- tion of a cell- type-specific enzymatic activity and mineraliza- tion, and in vivo, as assayed by bone formation fo...

Ngày tải lên: 14/08/2014, 14:22

... move beyond the constraints of studying only a few rather arbitrarily chosen model organ- isms and out into the diversity of pathologically, agricultur- ally, or evolutionarily interesting species. ... using protein chips that repre- sent the majority of the yeast proteome in order to identify all of the potential targets of a protein kinase in vitro. The combination of these in vivo an...

Ngày tải lên: 14/08/2014, 14:21

... predominantly intracellularly [26,27]. Cathepsin H, cathepsin C, cathepsin F, cathepsin W, cathepsin B and cathepsin S are also increased in expression in OA tissue Table 3 Fold change and threshold cycle ... disintegrin and metalloproteinase domain; ADAMTS: a disintegrin and metalloproteinase domain with thrombospondin motifs; Ct: threshold cycle; IGF: insulin-like growth factor; IL: in...

Ngày tải lên: 09/08/2014, 14:22

... H, Tanaka Y, Loomis WF: Changing patterns of gene expression in dictyostelium prestalk cell subtypes recognized by in situ hybridization with genes from microarray analyses. Eukaryot Cell 2003, 2:627-637. 27. ... [25]. Conservation of cell- type differentiation Developing Dictyostelium cells differentiate into two major cell types - prespore and prestalk. We tested how many genes...

Ngày tải lên: 09/08/2014, 20:21

... activity phase, respectively. In the adenohypophysis, minimal taurine levels coincided with the major plasma prolactin peak (at 01:00 h). Circulating prolactin and adenohypophysial taurine levels ... mechanisms in aging: 24-h rhythms of serum prolactin and median eminence and ade- nohypophysisla concentration of dopamine, serotonin, gamma aminobutyric acid, taurine and somatostatin in y...

Ngày tải lên: 10/08/2014, 09:20

... Recruiting and retaining low-income Latinos in psychotherapy research. Journal of Consulting & Clinical Psychology 1996, 64:868-874. 35. Heun R, Burkart M, Maier W: Selection biases during recruitment ... status as also being a potential inhibiter to both initially contacting and remaining in contact with some patients as they were attempting to remain undetected by other autho rities...

Ngày tải lên: 11/08/2014, 16:22

... open lung biopsy (patients A01, A02, A03) or by a combination of typical clinical and radi- ological findings on HRCT and a diagnostic BAL showing milky fluid and abundant extracellular periodic ... may help to estimate the degree of alveolar filling with proteinaceous material and to improve the efficiency of the wash out, especially in children. Introduction Pulmonary alveolar proteinosis...

Ngày tải lên: 12/08/2014, 18:20

... Freed PW, Westcott JY, Henson PM: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and ... mediated by soluble factors, primarily the proinflammatory cytokines granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor (GM-CSF), and possibly IL-...

Ngày tải lên: 12/08/2014, 19:22

... Tri- Council Policy Statement, which, in a subsequent section, states that ‘(b)eyond scrutinizing reports, the REB itself should not normally carry out the continuing ethics review, except in specific ... review in medicine. As recently as the early 1960s, peer review in research was viewed by many investigators and research administrators with the same suspicion that Percival undoubt...

Ngày tải lên: 12/08/2014, 20:20

... is enhanced/complemented by reintroduction of full length INI1 into these cells. Interestingly this enhancement was not efficient for virions deleted of IN indicating that per- haps, binding of IN to INI1 is required ... iso- lated as a binding partner for IN using the yeast two- hybrid system [20]. It directly interacts with IN in vitro and co-immunoprecipitates with Pol polyprotein...

Ngày tải lên: 13/08/2014, 09:20