Báo cáo y học: " Global approaches to understanding ubiquitination" pps

... most abundant topology, followed by Lys63 and Lys11 chains and the less frequent linkages through Lys33, Lys27, Lys6, and Lys29 (the latter is detected only in combination with Lys33 linkage) ... ubiquitin-proteasome system has started to attract global approaches that are beginning to make important contribu- tions to our understanding of the system. Chemistry-based approaches...

Ngày tải lên: 14/08/2014, 14:22

... protein-coupled receptor; receptor (fMLP-R26) binds bacterial N-formyl-methionyl peptides X91257 SERRS Seryl-tRNA synthetase 111.8 59.2 1.9 Cytosolic seryl-tRNA synthetase; class II aminoacyl tRNA synthetase, ... oxide synthase. Adenylate cyclase, 3.4 6.4 1.9 Adenylate cyclase (type 7), an ATP-pyrophosphate lyase; type VII converts ATP to cAMP C. Genes expressed in active untreated patients...

Ngày tải lên: 09/08/2014, 01:23

... genomics to classify cancers so far have been made with leukemia and lymphoma. A study of myelogenous and lymphocytic leukemias at Harvard with gene arrays demonstrated the ability to find distinguishing ... the Cancer Genome Anatomy Project [2], sponsored by the biotechnology industry and by government, have probably sequenced ESTs for nearly all of the estimated 100000–120000 total huma...

Ngày tải lên: 12/08/2014, 18:20

... pulmonary hyper- tension; PGI 2 = prostacyclin; PGIS = prostacyclin synthase; PH = pulmonary hypertension; PPAR = peroxisome proliferator-activated receptor; PPH = primary pulmonary hypertension; ... demonstrated, by in situ hybridization, western analysis and immunohis- tochemistry, that patients with PPH have decreased lung tissue prostacyclin synthase (PGIS) [7]. A comprehensive histochemi...

Ngày tải lên: 12/08/2014, 18:20

... report New approaches to the modulation of inflammatory processes in airway disease models: ATS 2001, May 18–23, San Francisco David J Hele Respiratory Pharmacology Group, Cardiothoracic Surgery, Imperial ... high local anti-inflammatory activity. The anti-inflammatory effi- cacy of Ciclesonide in these studies was similar to that produced by Fluticasone but with an improved safety prof...

Ngày tải lên: 12/08/2014, 18:20

... periplasm or cytoplasm by efflux pumps. In some cases, drug resistance is due to a combination of these mechanisms. Drugs Porin Drug target Periplasm Cell wall Cytoplasmic membrane Cytoplasm Enzyme Modified ... outer membrane, the peptidoglycan cell wall, the periplasm, which contains enzymes required to synthesize the cell wall, and the cytoplasmic membrane. (a) The entry point and targ...

Ngày tải lên: 14/08/2014, 16:20

... regulatory networks that interact in a variety of ways [1,7]. Transcription factors modify chromatin structure by recruiting enzymes that remodel nucleosomes or posttransla- tionally modify histones ... in yeast is largely devoid of nucleosomes. We systematically evaluated nucleosome occupancy in yeast promoters by immunoprecipitating nucleosomal DNA and quantifying enrichment by microarrays....

Ngày tải lên: 14/08/2014, 14:21

... only one nurse on duty on the paediatric ward, and even during the day it was rare for a nurse to be specifically assigned to the newborn nursery. Hospitals were relatively poorly equipped to ... and although they considerably increase the total Table 1: Simple description of tools used and purpose of each tool Data collection Tool Focus of data collection Facility inventory checklists....

Ngày tải lên: 11/08/2014, 05:21

... Kim EJ, Neumann D, Schroeder JI: Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. EMBO J 1999, 18:3325-3333. 46. Borrelly GP, Harrison MD, Robinson AK, ... is often not possible to investigate underlying defects directly. Key to the applicability of these models is the extent to which they accurately reflect the biologic system of inter- est...

Ngày tải lên: 14/08/2014, 07:21

... they divided DR Congo into two strata along the 2001 line of military con- trol: an east stratum of territory formerly held by rebel groups and a west stratum of territory formerly held by government ... 5 [36,37], the reliability of a mortality estimate can vary widely. If one were to rely only on the first estimate from that study, as many have, one would incorrectly infer that 500,000 ch...

Ngày tải lên: 25/10/2012, 10:31