Báo cáo y học: "A computational method to predict genetically encoded rare amino acids in proteins" pdf

... to incorporate two additional amino acids with distinct functionality, selenocysteine and pyrrolysine. These rare amino acids can be overlooked inadvertently, however, as they arise by recoding ... read-through cases. Putative pyrrolysine recoding in archaea The RSA method was also used to search for proteins poten- tially containing the pyrrolysine residue, the so-called 22...

Ngày tải lên: 14/08/2014, 14:22

... unexpressed mRNAs in certain cells will be predicted to be t argets by Bioinformatics. Hybrid-PCR has much more flexibil- ityandcanbeusedtoidentifytargetmRNAsfora miRNA from any kind of cells at ... rine sample of a 5-month-old infant hospitalized in Shengjing Hospital of China Medical University. Han strain was p assa ged six t imes in human embryonic lung fibroblasts (HELF) maintain...

Ngày tải lên: 11/08/2014, 21:21

... mixture of baits. For example, intravenously administered phage display library has been successfully used for in vivo bio-panning in certain animal model systems to identify tissue-specific peptide ... synthetic biotinylated TMG peptide (Fig. 1C, TMG). Conversely, phages displaying the TMG peptide bind to a synthetic biotinylated DSP peptide (Fig. 1C, DSP). In the absence of biotin...

Ngày tải lên: 11/08/2014, 10:23

... presented a way to expand the size of a certificate by zipping. Combining the existing knowledge to create cyclic certificates with this zipping technique resulted in the Cyclic Zipper method. Using this ... constraints we refer to [4]. By using additional constraints - also known as streamlining [7] or tunnelling [11] - patterns can be forced to reduce the search space. Point symmet...

Ngày tải lên: 07/08/2014, 15:22

... the inflammatory state of the disease Extracellular proteases are secreted in SF by infiltrating inflam- matory cells and/or by stromal cells stimulated by inflammatory cytokines [21,22]. To ... proteolytic activity. This suggests that, in the case of arthritis with involvement of several joints, systemic factors play a dominant role in controlling the local proteolytic activity. Fin...

Ngày tải lên: 09/08/2014, 08:22

... PTB: polypyrimidine tract-binding protein; SF: splicing factor; SFBS: splicing factor binding site; SR: serine-arginine-rich; SS: sum of scores; TPR: true positive rate; TSI: tissue specifi- city index; ... shown to play a critical role in regulating tissue-specific (mainly brain) exons, including its own mRNA [53]. In the core network, PTB is found in the first layer, but it has in-...

Ngày tải lên: 14/08/2014, 21:20

... Symptoms in HCV infection do not appear to be linked to disease activity; neither do appear to be correlated with serum aminotransferase levels or liver histological findings [15,16]. In ... A phase II study indicated a lower rate of anemia induced by viramidine than ribavirin. However, its efficacy remains to be determined by ongoing clinical trials. Several types of HCV-s...

Ngày tải lên: 02/11/2012, 09:51

... hepatic inflammation carry a significantly higher risk of disease progression. Histological staging of HBV disease is clinically very valuable in assessing degree of fibrosis and predicting disease ... liver biopsy may not be necessary. As it will be discussed below, histological assessment is very valuable in determining HBV treatment in patients with persistently normal transaminas...

Ngày tải lên: 03/11/2012, 09:41

... surgeries NOVARFIL: polybutester polymer monofilament indefinitely / good Skin closure POLYURETHANE: polyurethane polymer monofilament indefinitely / very good Skin closure, general, cardiovas- cular, ... threads, like polypropylene and polyamide, in relation to wound sealing and scar formation. Key words: suture threads, polyurethane, polypropylene, polyamide, wound-lip-sealing p...

Ngày tải lên: 03/11/2012, 11:52

... appear, linguistically, in the text (they refer to items in the external world rather than things referred to in the text). Finally, the third category is that of pronouns that will be resolved by our computational ... computational processing, semantic and domain information is computationally inefficient when compared to other kinds of knowledge. Consequently, current anapho...

Ngày tải lên: 17/03/2014, 07:20