Báo cáo y học: "Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals" ppt

... research interactions information Open Access 2005Chamary and HurstVolume 6, Issue 9, Article R75 Research Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure ... reconstructions.Click here for fileAdditional data file 3A table of the stability of mRNA secondary structures for short genesA table of the stability...

Ngày tải lên: 14/08/2014, 14:22

... these conditions (> 10 h [16], and additional data, not shown). Decay of ARE-containing transcripts was investigated by expressing b-globin reporter constructs containing the regulatory region of ... activated by a different upstream component. The lack of inhibition by both kinase mutants together strongly indicates that the effect of UV light on mRNA stability is independen...

Ngày tải lên: 31/03/2014, 08:20

... therapy by only a few months decreased the ability of the monotherapy to induce remis- sion [20]. The benefits of combination therapy were unaf- fected by delay. Not all trials of early combination ... Combination Therapy Trial Group: Delay to institution of therapy and induc- tion of remission using single-drug or combination-disease- modifying antirheumatic drug therapy in early...

Ngày tải lên: 09/08/2014, 01:23

... were blocked for 15 minutes with moderate agitation in a 143 mM solution of succinic anhydride dissolved in 1-methyl-2-pyrolid- inone, 20 mM sodium borate, pH 8.0. Slides were rinsed for 2 minutes in distilled ... those relationships were compared with healthy con- trols. These findings strongly suggest that neutrophils are chronically dysregulated in polyarticular JRA and that...

Ngày tải lên: 09/08/2014, 08:22

... the miR-485-5p binding site in the coding region of BACE1 mRNA. Noncoding RNAs compete for binding sites Considering that BACE1-AS and miR-485-5p share potential binding sites in the BACE1 mRNA, we ... association with any position on a target mRNA is mechanistically sufficient for binding. In our bioinformatics study, we showed that miRNAs are predicted to target the non-o...

Ngày tải lên: 09/08/2014, 20:22

... examine the concurrent validity of a mini-interview for personality disorder Structured Assessment of personality - Abbreviated Scale [4]. In ordertodothis,weconductedaseriesofsecondary analyses ... Disabilities interview Schedule-IV (AUDADIS-IV) is a fully struc- tured interview covering a range of disorders, including personality disorders. At the time of this study, only the pr...

Ngày tải lên: 11/08/2014, 16:22

... expression fluctuates only mildly [39]. The DNA binding specificities and activ- ities of the isoforms also differ. In rat, this results in RORB2 demonstrating increased activity in non-neuronal cells, ... Hospital, Boston, MA, USA, 2 Department of Biology, Indiana University, Bloomington, IN, USA, 3 Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA,...

Ngày tải lên: 11/08/2014, 17:20

... sizes of heterodiploid and recombining subpop- ulations of viruses may coincide. In this study, we have investigated whether there is a pref- erence in the formation of homodiploid virions during the ... molecules synthesized on the same DNA-provirus. This property of Mo-MuLV may explain why only small subpopulations of gammaretroviruses produce recombinants. In this con- te...

Ngày tải lên: 13/08/2014, 13:20

... situation could include the formation of physical gene clusters (to reduce the chances of coding for only part of the pathway, or for strong repression of transcription mediated by chromatin remodelling), ... also involves the pro- duction of a toxic intermediate, there can be strong selection in favor of the pathway in some conditions and strong selec- tion against it...

Ngày tải lên: 14/08/2014, 08:20

... nucleotides in a structured RNA are rigidly held in a conformation that does not permit the formation of an in- line geometry, and therefore these sites cleave slowly. In contrast, internucleotide linkages ... are chosen based on the proximity that representatives from A. tumefaciens have to genes. serC U Y UUUU GUUUCCCCCYYCURAU Y GC R R G Y Y 5′ YG YY Y YY Y Terminator A...

Ngày tải lên: 14/08/2014, 14:22