Báo cáo y học: "Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals" ppt
Báo cáo y học: "Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals" ppt
... research interactions informationOpen Access2005Chamary and HurstVolume 6, Issue 9, Article R75ResearchEvidence for selection on synonymous mutations affecting stability of mRNA secondary structure ... reconstructions.Click here for fileAdditional data file 3A table of the stability of mRNA secondary structures for short genesA table of the stability of mRNA secondary structures for short genes (only ... evolution of a sta-ble structure for mRNA would be constrained by the need toencode a functional protein [17-19,29-31]. Consequently,were selection to operate on mRNA stability, synonymous mutations...
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Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf
... theseconditions (> 10 h [16], and additional data, not shown).Decay of ARE-containing transcripts was investigated byexpressing b-globin reporter constructs containing theregulatory region of ... activated by a different upstreamcomponent. The lack of inhibition by both kinase mutantstogether strongly indicates that the effect of UV light on mRNA stability is independent of the p38 MAP kinase/MK2 ... Alternatively,HuR may affect only the fate of a subset (i.e. ARE-containing) of mRNAs in response to UV light. Of note,activation of the p38 pathway did not seem to affect HuRbinding to the...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps
... therapy by only a few monthsdecreased the ability of the monotherapy to induce remis-sion [20]. The benefits of combination therapy were unaf-fected by delay.Not all trials of early combination ... CombinationTherapy Trial Group: Delay to institution of therapy and induc-tion of remission using single-drug or combination-disease-modifying antirheumatic drug therapy in early rheumatoidarthritis. ... combinationtherapy but only 11 of 98 patients achieved remission withmonotherapy. Remission remained more frequent withcombination therapy at 2 years. Subsequent analysesfound that delaying...
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Báo cáo y học: "Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis" pdf
... wereblocked for 15 minutes with moderate agitation in a 143 mMsolution of succinic anhydride dissolved in 1-methyl-2-pyrolid-inone, 20 mM sodium borate, pH 8.0. Slides were rinsed for 2minutes in distilled ... those relationships were compared with healthy con-trols. These findings strongly suggest that neutrophils arechronically dysregulated in polyarticular JRA and that therapyonly minimally ameliorates ... initial 95°C step for 10 minutes (for Taqactivation), followed by 40 cycles of 95°C for 15 seconds,60°C for 1 minute, and then a final melting curve analysis witha ramp from 60°C to 95°C for...
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Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx
... themiR-485-5p binding site in the coding region of BACE1 mRNA. Noncoding RNAs compete for binding sitesConsidering that BACE1-AS and miR-485-5p sharepotential binding sites in the BACE1 mRNA, we ... association with any position on a target mRNA is mechanistically sufficient for binding. In our bioinformatics study, we showed that miRNAsare predicted to target the non-overlapping region of sense-antisense ... 3 of 13Figure 1 BACE1-AS and miR-485-5p competing for the same binding site in BACE1 mRNA. (a) Sequence information of miR-485-5p and its tar-get site in BACE1 mRNA. Binding site in BACE1 mRNA...
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Báo cáo y học: " Screening for personality disorder with the Standardised Assessment of Personality: Abbreviated Scale (SAPAS): further evidence of concurrent validity" docx
... examine the concurrent validity of amini-interview for personality disorder StructuredAssessment of personality - Abbreviated Scale [4]. In ordertodothis,weconductedaseriesofsecondaryanalyses ... Disabilitiesinterview Schedule-IV (AUDADIS-IV) is a fully struc-tured interview covering a range of disorders, includingpersonality disorders. At the time of this study, only theproportions of the interview ... and number of per-sonality disorder criteria controlling for various con-founders, one for each cluster, and one for total number of personality disorder criteria. In each regression, thedependent...
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Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx
... expression fluctuatesonly mildly [39]. The DNA binding specificities and activ-ities of the isoforms also differ. In rat, this results in RORB2 demonstrating increased activity in non-neuronalcells, ... Hospital, Boston, MA, USA, 2Department of Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, ... nine amino acidsprecede the first cysteine of the DNA binding domain,while in RORB2 there are twenty residues before thiscysteine. The two forms of the protein exhibit differentialexpression...
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Báo cáo y học: " Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site" ppt
... sizes of heterodiploid and recombining subpop-ulations of viruses may coincide. In this study, we have investigated whether there is a pref-erence in the formation of homodiploid virions duringthe ... moleculessynthesized on the same DNA-provirus. This property of Mo-MuLV may explain why only small subpopulations of gammaretroviruses produce recombinants. In this con-text, the differences in the ... dimerization of genomic RNAs of gamma-retroviruses occurs immediately after transcription in thecell nucleus and heterodimerization involves only minorpopulations of RNA molecules left in a monomeric...
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Báo cáo y học: " Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi" potx
... situationcould include the formation of physical gene clusters (toreduce the chances of coding for only part of the pathway, or for strong repression of transcription mediated by chromatinremodelling), ... also involves the pro-duction of a toxic intermediate, there can be strong selection in favor of the pathway in some conditions and strong selec-tion against it in others. The consequences of ... in the formation and mainte-nance of clusters include selection for co-regulation by chro-matin remodelling, epistatic selection for tight linkagebetween genetically interacting genes, and...
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Báo cáo y học: "Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria" pps
... nucleotides in a structured RNAare rigidly held in a conformation that does not permit theformation of an in- line geometry, and therefore these sitescleave slowly. In contrast, internucleotide linkages ... are chosen based on the proximity that representatives from A. tumefaciens have to genes.serCU Y UUUUGUUUCCCCCYYCURAU Y GCRRG Y Y5′YGYY Y YY Y TerminatorAAGCRYRYGCGCACGCCCACA5′RUUAGCAUGUGGG ... elements of an adjoining expressionplatform, which modulates the expression of downstreamgenes. The two most common types of expression platformscontrol either the formation of intrinsic transcription...
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