Báo cáo y học: "Human genetics moves from clinic to bench - and back" ppsx

... disorders. High-throughput technology and data analysis On the high-throughput front, a novel array-based whole- genome genotyping assay that effectively enables unlimited SNP genotyping from a single ... related to their selection to respond to environmental stress. The cytochrome P450 isoenzymes CYP2C19 and CYP2D6, for example, are involved in the metabolism of many widely used...

Ngày tải lên: 14/08/2014, 14:22

... with cis-regulatory loci in 16% of the miRNAs studied by her team, for example, miR-100 and miR-16. Association of miRNA expression with trans-regulatory loci was found in only 5% of the miRNAs analyzed, ... described that a low copy number of the CNV spanning the gene for the low-affinity Fc receptor for IgG (FCGR3B) is a risk factor for systemic lupus erythematosus and other autoimmune...

Ngày tải lên: 14/08/2014, 20:22

... purposes) (MMP-1, -8 , and -1 3), the gelatinases (MMP-2 and -9 ), the stromelysins (MMP-3, -1 0, and -1 1), the matrilysins (MMP-7 and -2 6), and the membrane-bound-type MMPs (MMP-14, - 15, -1 6, -1 7, -2 4, and -2 5). ... 3 13-HODE and 15-HETE downregulate induction of MMP-1/MMP-13 protein synthesis by IL-1β, TNF-α and IL-1713-HODE and 15-...

Ngày tải lên: 09/08/2014, 14:20

... microflora, pregnancy and impact on body function due to systemic absorption or inflammatory response. Symptoms and colposcopy do not necessarily indicate safety and recent outcomes of tri- als suggest ... policy and pro- grammes to build the social and health platform for the adolescents (10–19 years), youth (15–24 years), espe- cially young girls [67]. Conventional "youth...

Ngày tải lên: 10/08/2014, 05:21

... IL-6, IL-10, IFN-g and TGFb-1 genes are differentially upregulated in both adipose and liver tissues of HFC-fed mice. Expression levels of IL-6, IL-10, IFN-g and TGFb-1 from chow (in black) and HFC ... GM-CSF, TNF-a,IL-12p7 0and IL-1b in these HFC-mice. Serum amyloid A (SAA) levels were variable at 6 and 16 weeks post-HFC but wer e sig- nificantlyelevatedintheHFC-fedmiceat26weeks...

Ngày tải lên: 11/08/2014, 03:20

... GM-CSF, TNF-a,IL-12p7 0and IL-1b in these HFC-mice. Serum amyloid A (SAA) levels were variable at 6 and 16 weeks post-HFC but wer e sig- nificantlyelevatedintheHFC-fedmiceat26weeks post-HFC. IL-10 ... HFC-fed mice A complex regulation of pro-inflammatory cytokine genes was observed at different time points in both adi- pose and liver tissues, underlying both disease-promoting and compe...

Ngày tải lên: 11/08/2014, 06:22

... were cen- trifuged and stored at -8 0°C before HHV-8 serologic testing. Laboratory procedures The coded serum specimens were tested for HHV-8 anti- gens of ORF 73 ,ORF 65 and K8.1 using enzyme-linked immunosorbent ... 1995, 1:70 7-7 08. 3. Cesarman E, Chang Y, Moore PS, et al: Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N E...

Ngày tải lên: 12/08/2014, 04:20

... activity of the G-protein regulators GPR-1 and GPR-2 (GPR1/2). CK1 func- tions upstream of phosphatidylinositol-4-phosphate 5-kinase (PPK-1), a protein that generates phosphatidylinositol diphos- phate ... position and orientation. chp-1 is also known to function in maintain- ing the balance between anterior and posterior PAR (partitioning-defective) proteins. CHP-1 normally localizes...

Ngày tải lên: 14/08/2014, 15:20

... ReMoDiscovery correlation threshold GRAM mo du le p-value cutoff 0.05 0.045 0.04 0.035 0.03 0.025 0.02 0.015 0.01 0.005 GRAM co re pr ofil e p -value cu to ff -3 -4 -5 -6 -7 -8 -9 -1 0 -1 1 -1 2 (a) ... ACE2_YPD, FKH1_YPD, FKH2_H2O2Hi, FKH2_H2O2Lo, FKH2_YPD, MBF1_YPD, MBP1_H2O2Hi, MBP1_H2O2Lo, MBP1_YPD, MCM1_Alpha, MCM1_YPD, NDD1_YPD, RFX1_YPD, RPN4_YPD, STB1_Y...

Ngày tải lên: 14/08/2014, 16:21

... manu- ally. The type of indicators recorded - and the actual fig- ures tallied - seemed to reflect only a portion of the actual PMTCT and ART activity, and the data were generally of poor quality. ... short-course zidovudine regimen to prevent mother -to- child transmission of HIV-1 in West Africa. Journal of Acquired Immune Deficiency Syndromes 2002, 16:63 1-6 41. 30. Co...

Ngày tải lên: 10/08/2014, 05:22