Báo cáo y học: "Using genomics to deliver natural products from symbiotic bacteria" pps

... two pathways - made a strong case that the pathway had been identified, the failure to identify or culture the bacterial symbiont and the inability to express the pathway heterologously in an alternative ... adenyla- tion domain - a highly conserved and repetitive domain found in enzymes of the nonribosomal-peptide biosynthetic assembly line - yielded only a single candidate gene, and fur...

Ngày tải lên: 14/08/2014, 14:22

... of all articles included in the study were read in full independently by two authors (TYC, JIK). Data from the articles were validated and extracted according to pre-defined criteria (Table 1). TheCochraneclassificationwithfourcriteria(i.e. sequence ... spondylosis treated by Guasha. Zhongyi Waizhi Zazhi 1995, 2:40. 11. Wang ZG, Tao Y, Wu NT: The effect of coin scraping therapy for the t...

Ngày tải lên: 13/08/2014, 15:21

... 1 Ontologies to be incorporated in a combinatorial phenotype ontology Ontology Description URL Adult anatomy The Anatomical Dictionary for the Adult Mouse [17] has been developed by Terry Hayamizu, ... Mouse Phenotype Ontology The schema was designed to be easily populated using extant core ontologies, such as anatomy, and defining attributes related to each entity. The assay vocabulary...

Ngày tải lên: 14/08/2014, 14:21

... multiple types of stressors on the physiology and symptomatology of patients with RA. Collectively, laboratory research has docu- mented a maladaptively pro-inflammatory response to stress among RA patients, ... pro-inflammatory cytokine responses to acute stress, perhaps conferred by genotype or early environmental experi- ence, represent a risk factor for the development of RA or other...

Ngày tải lên: 09/08/2014, 14:20

... atypical symptom complex may result from the inability to mount a robust inflammatory response. These observations were mirrored by those of Wilson and colleagues [17] who described a similar symptom ... are typically skewed toward the production of Th2-type cytokines; the relatively limited capacity for a Th1 response (TNF, IL-12, IFNg) has been interpreted as functionally adaptive, serv...

Ngày tải lên: 12/08/2014, 02:20

... 2 TTACAAA -172 to -166 TTAGTAA -373 to -367 CgYRE2 CgYRE3 Wild type CgYREnull CgYRE2mut 3 CgYRE3mut 2 ScYap1p Cgap1p TTAGTCA -149 to -143 TGACTAA -168 to -162 TTACTAA -365 to -359 YRE3 YRE1YRE2 ScFLR1 ... promoter 3 1 Wild type YREnull 2 YREnull YRE3::CgYRE3 3 CgYRE3 YREnull YRE3::CgYRE3 YRE2::CgYRE2 3 CgYRE3 2 CgYRE2 (b) (a) 0 1 2 3 4 5 6 7 LacZ expressionLacZ expression 0 1 2 3 4...

Ngày tải lên: 14/08/2014, 21:20

... phenotype and genotype. For example, Ferdig addressed the limitations of our (historically necessary) simple ‘one gene-one pheno- type’ paradigms head-on by pointing out that whereas atovaquone ... sequencing high-quality samples directly from the field and resolving mixed infections are being tackled to improve the application of this technology to parasites collected directly fr...

Ngày tải lên: 14/08/2014, 21:21

... the capacity to systematically assess preventable adverse events, which are defined as poor outcomes caused by errors or system design flaws. We describe how we used MET calls to systematically identify ... Emergency Teams (METs), alternatively known as Rapid Response Teams, have recently been implemented in many hospitals worldwide [1]. The primary role of an MET is to improve the earl...

Ngày tải lên: 25/10/2012, 10:06

... Donnelly Centre, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada. 3 Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON ... a comparative genomics approach that exploits evolution- ary signatures, they ultimately are likely to correspond to biophysically different phenomena. In a similar fashion, modern secondary...

Ngày tải lên: 09/08/2014, 22:23

... disease to lung Baseline pulmonary function 79 ± 8 FEV 1 % 74 ± 22 DLCO%* Type of surgery performed** 6 Pneumonectomy 40 Lobectomy *DLCO results were available on only 84 patients. **Postoperative ... Comparison Pneumonectomy 2.38% (-4.69% to -0.07%) -23.79% to 19.04% Perfusion scintigraphy and VRI -2.42% (-4.49% to -0.35%) -21.61% to 16.78% Ventilation scintigraphy and VRI 0.04% (-...

Ngày tải lên: 10/08/2014, 09:22