Báo cáo y học: "ystems biology: where it’s at in 2005" ppsx

... a library of fluo- rescently tagged cDNAs in vivo using live cell arrays (similar to those described by Sabatini), again with or without stimu- lation of a signaling pathway. Phosphorylation events ... move beyond the constraints of studying only a few rather arbitrarily chosen model organ- isms and out into the diversity of pathologically, agricultur- ally, or evolutionarily interesting sp...

Ngày tải lên: 14/08/2014, 14:21

... effects by targeting immunotoxins to viral determinants [7]. The risk of a spreading infection by virus newly induced to replicate is generally mitigated in these scenarios by HAART. Attacking the ... successful treatment remains plagued by multiple, clinically latent viral reservoirs largely impervious to antiretroviral drugs. The microbiology of clinical latency is controversial and may i...

Ngày tải lên: 13/08/2014, 06:20

... differentiation path- ways. In these systems, therefore, inactivating enzymes in MAP kinase cascades have a key role not only in suppressing the level of pathway activity in unstimulated cells and during recovery ... al. [3] - that EGF induces hMSC osteoblast differentiation by activating the MAP kinase pathway, whereas PDGF stimulation avoids the differentiation response by stimulati...

Ngày tải lên: 14/08/2014, 14:22

... only in one-third of late septic shock patients [12]. Additionally, the increase in arterial pressure during AVP infusion occurs independently of plasma AVP concentrations [9,13]. AVP therapy at ... responding to conventional therapy [15]. Therefore, institution of AVP infusion in advanced septic shock should not be guided by endocrinologic, but by hemodynamic indications! Whether the...

Ngày tải lên: 12/08/2014, 20:20

... available at [http://meetings.cshl. edu/meetings/abstracts/2006systems_absstat.html]. Studying genome occupancy and protein-DNA interactions Chromatin immunoprecipitation followed either by DNA hybridization ... expression at the Cold Spring Harbor Labo- ratory was to promote this synthesis by bringing together experimentalists and computational biologists with a common interest in stu...

Ngày tải lên: 14/08/2014, 16:21

... studies. In terms of a potential therapeutic, our data show that hMSCs are effective at attenuating or reversing the inflammation and pathology associated with acute asthma in the ovalbumin murine ... adverse events. In studies using the bleomycin model, administration of hMSCs into mice immediately after exposure to bleomy- cin was associated with a significant reduction in inflam-...

Ngày tải lên: 11/08/2014, 03:20

... translated into proteins. By 2051 we will have developed techniques that will tell us within several hours, or even minutes, what pattern of proteins a patient has. Some recent data from my laboratory ... created a database of proteins by taking them out of the cells, running them in a two-dimensional gel, visualizing the gel using an informatics system, and deducing which spots are upregul...

Ngày tải lên: 12/08/2014, 18:21

... hormone. Available online http://ccforum.com/content/6/5/381 In the early 1980s we were big proponents of using corticosteroids in septic shock, whereas in the late 1980s, following publication of the findings ... assistance in helping us write this commentary. We also thank the International Sepsis Forum (ISF) and the Society of Critical Care Medicine (SCCM) for inviting Charles Spru...

Ngày tải lên: 12/08/2014, 18:21

... (ISF). Abstract Sepsis, the life-threatening illness that arises from innate immunity to overwhelming infection, is treated symptomatically at the start of the 21st century. Looking ahead 50 years, one can perhaps ... significant role in defining the response to an infectious stimulus and in determining the outcome following an intervention [3]. The capacity to detect genetic polymorphi...

Ngày tải lên: 12/08/2014, 19:21