Báo cáo y học: "Genomic analysis of metabolic pathway gene expression in mice" pps

... properly cited. metabolic pathway gene expression in mice<p> ;In order to evaluate metabolic pathways associated with obesity, global gene- expression data were integrated with phenotypic and genetic ... allows identification of specific pathways whose gene expression is coordinately regulated in association with obesity, defined genomic regulatory loci controllin...

Ngày tải lên: 14/08/2014, 14:21

... accurate measure of Hsf 'binding affinity' or that simple binding site prediction is not a reliable way of identifying genuine HSEs. Comparative analysis Two genome-wide studies in the budding yeast ... transcriptional start of responsive genes [24], we reasoned that we could identify new genes with Hsf-binding sites by performing a ChIP-array analysis using arrays conta...

Ngày tải lên: 14/08/2014, 14:21

... 28 percentage of miRNAs, of whichthetotalnumber(N Rank1-27 ) of thetargetswithlower ranknumber(between1and27)ismorethanthenumber(N Rank29-55 ) of thetargetswith higherranknumber(between29and55)(RRvalue>1).  Figure3 Overall expression levels of miRNAtargets in mousetissues.Theaverage expression levels of themiRNAtargetsandthetotalgenes in each...

Ngày tải lên: 14/08/2014, 16:20

... vessels following lung injury by V 2 O 5 . Polypeptide growth factors have a variety of functions in airway remodeling that occurs after metal-induced lung injury. Our genomic analysis identified ... of Cytokine Signaling-3 Cytoplasmic Cell Signaling Hs.50640 SOCS1 Suppressor of Cytokine Signaling-1 Cytoplasmic Cell Signaling Hs.470943 STAT1 Signal Transducer Activator of Transcri...

Ngày tải lên: 12/08/2014, 15:20

... cut-offs are arbitrary and chosen because they resulted in about half of the genes falling into 'average' gene expres- sion and the remainder of the genes falling roughly equally into ... synonymous and nonsynonymous sites were examined for the coding regions of each gene. Additionally, because regulatory elements are often found in first introns, levels of polymorphi...

Ngày tải lên: 14/08/2014, 20:22

... surface via its interaction with the b-catenin [31]. This interaction is regulated mainly by two mechanisms, via the phosphorylation status of each partner of the b-catenin pathwaycausedbytheGSK3b, ... serine residues carrying O-linked glycan chains and distributed in tandemly repeated motifs in the central part of the protein backbone. Mucins are known to play important roles in...

Ngày tải lên: 17/03/2014, 23:20

... resource for systems biology. In the haploinsuffi- ciency profiling (HIP) assay consisting of all 6,000 heterozygous deletions (where one copy of each gene is deleted), most strains (97%) grow ... together (Figure 2c): rapamycin, calyculin A and wiskostatin. The similar- ity in these profiles resulted from inhibition of strains deleted for genes involved in intracellular transpo...

Ngày tải lên: 09/08/2014, 20:21

... transition to subgenotype D1 in the East of the continent. HBV genetic variability may lead to wrong results in rapid genotyping methods and sequence analysis is needed to clarify atypical results. Background Hepatitis ... are indicated by their accession number. Table 2 Clinical status, subgenotype and genotype of HBV strains according to the genotyping method Genotype determined u...

Ngày tải lên: 12/08/2014, 02:20

... manual analysis of the human-mouse syntenic pseu- dogenes indicates that the pseudogene of RPS27 is very likely to be a functional protein-coding gene (RPS27L) highly simi- lar to RPS27. The proteins ... protein is regulated by the expression of its pseu- dogene in the human genome [15]. Thus, processed pseudo- genes are emerging as interesting elements in the genomic landscap...

Ngày tải lên: 14/08/2014, 21:20

... of the Sin3 binding domain of Mad in silencing gene expression when fused to DNA binding proteins has been demonstrated in two studies. One groupfusedtheMadSIDtothec-Jun DNA binding domain and ... gonadotropin responsiveness and inhibin expression [8]. In addition, KK1 cells are easy to maintain in culture and can be transfected with high efficiency . The data generated usin...

Ngày tải lên: 20/06/2014, 07:20