Báo cáo y học: "Transcription regulation: no holy grail, but many treasures" pot

... example, the histone acetyltransferase MOZ (monocytic leukemia zinc finger protein) is fused to the histone acetyltransferase CBP. David Heery (University of Nottingham, UK) revealed that another translocation ... http://genomebiology.com/2005/6/7/334 Genome Biology 2005, 6:334 38, which is inhibited by methylation of lysine (K) 36. In turn, Frp4 antagonizes H3 K36 methylation. Smads are a f...

Ngày tải lên: 14/08/2014, 14:21

... discussed a hypothesis, first proposed by Mary Lyon a few years ago, that repression may occur more efficiently on the X chromosome as a result of its high density of LINE repeats. Interestingly, a large region ... inactive X is hypermethylated only in gene-rich regions but, unexpectedly, relatively hypomethylated in gene-poor regions. Also, gene-rich regions on autosomal chromosomes are mor...

Ngày tải lên: 14/08/2014, 16:20

... contribute to IL-1 induction. Recently, Firestein and colleagues have demonstrated that the JNK pathway, but not the p38 pathway is required for cytokine induction of MMP-1 in human rheumatoid synovial ... chondrocytes, and perhaps synovial cells, can produce this enzyme [13,14]. MMP-13 may have a partic- ular role in cartilage degradation because it is expressed by chondrocytes, and becaus...

Ngày tải lên: 09/08/2014, 03:24

... increased activity of NOS may represent predominantly of nNOS isoform. In reper- fusion group the activity may be attributed to iNOS and nNOS and increased activity may be mainly by iNOS due to ... group may be attributed to iNOS and nNOS and the relative contribution to the increased activity in reperfusion may be mainly the iNOS form and some contribution by nNOS, as reported that nNO...

Ngày tải lên: 26/10/2012, 09:07

... immunohistochemistry and immunocytochemistry and Western blot. Stimulation of Y1 cells with ACTH significantly stimulated endogenous mitochondrial thioesterases activity (1.8-fold). Nordihydro- guaiaretic ... steroidogenesis is currently not known. The high degree of sequence similarity between the CTE-I and MTE-I genes suggests that they diverged relatively recently by gene duplication, poss...

Ngày tải lên: 08/03/2014, 09:20

... key enzyme hydrogenase, which is synthesized only after an anaerobic adaptation, catalyzes the reversible reduction of protons to molecular hydrogen. Hydrogenases are found in nearly all taxonomic ... of anaerobic microbes, where they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen [16]. Interestingly, Fe-hydrogenases were not found in cyanobacteria, th...

Ngày tải lên: 08/03/2014, 22:20

... J.O., Whang- Peng,J.&Haynes,B.F.(1984)Conversionofastemcellleukemia from a T-lymphoid to a myeloid phenotype induced by the ade- nosine deaminase inhibitor 2¢-deoxycoformycin. Proc. Natl Acad. Sci. ... decreased, while megakaryocytes, granulocytes and monocytes appear to be normal. The v-Myb gene, transduced by avian myeloblastosis virus (AMV), is an oncogene that specifically blocks termi...

Ngày tải lên: 08/03/2014, 22:20

... activity was dramatically diminished. Alternatively, hTR and hTERT may play a minimal catalytic activity in telomerase, while the assembly of other telomerase subunits may amplify the enzyme function. ... amplification protocol-enzyme immunoas- say (TRAP/EIA) as described previously [27]. Telomerase activity was determined by the ability to produce telomere repeats by a PCR-based TRAP assay an...

Ngày tải lên: 17/03/2014, 23:20

... Fibroblast- like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and ... microarray technology has provided a powerful tool to gain insight into the molecular complexity of these diseases; this technology facilitates open-ended survey to identify comprehensively...

Ngày tải lên: 09/08/2014, 01:22

... immunity IL-6 is a pro-inflammatory cytokine that has a progressive function in many inflammatory diseases, whereas IL-10 is an immunoregulatory cytokine that has potent anti-inflammatory activity. ... & Therapy June 2005 Vol 7 No 3 Yoshimura et al. Abstract Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cy...

Ngày tải lên: 09/08/2014, 06:23