Báo cáo y học: "Transcription regulation: no holy grail, but many treasures" pot
Báo cáo y học: "Transcription regulation: no holy grail, but many treasures" pot
... example,
the histone acetyltransferase MOZ (monocytic leukemia
zinc finger protein) is fused to the histone acetyltransferase
CBP. David Heery (University of Nottingham, UK) revealed
that another translocation ... http://genomebiology.com/2005/6/7/334
Genome Biology 2005, 6:334
38, which is inhibited by methylation of lysine (K) 36. In
turn, Frp4 antagonizes H3 K36 methylation.
Smads are a f...
Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps
... discussed a hypothesis,
first proposed by Mary Lyon a few years ago, that repression
may occur more efficiently on the X chromosome as a result
of its high density of LINE repeats. Interestingly, a large
region ... inactive X is hypermethylated
only in gene-rich regions but, unexpectedly, relatively
hypomethylated in gene-poor regions. Also, gene-rich
regions on autosomal chromosomes are mor...
Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... contribute to IL-1 induction. Recently,
Firestein and colleagues have demonstrated that the JNK
pathway, but not the p38 pathway is required for cytokine
induction of MMP-1 in human rheumatoid synovial ... chondrocytes, and perhaps synovial cells, can
produce this enzyme [13,14]. MMP-13 may have a partic-
ular role in cartilage degradation because it is expressed
by chondrocytes, and becaus...
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... increased activity of NOS may
represent predominantly of nNOS isoform. In reper-
fusion group the activity may be attributed to iNOS
and nNOS and increased activity may be mainly by
iNOS due to ... group may be attributed to iNOS and nNOS
and the relative contribution to the increased activity
in reperfusion may be mainly the iNOS form and
some contribution by nNOS, as reported that nNO...
Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... immunohistochemistry and
immunocytochemistry and Western blot. Stimulation of
Y1 cells with ACTH significantly stimulated endogenous
mitochondrial thioesterases activity (1.8-fold). Nordihydro-
guaiaretic ... steroidogenesis is currently
not known. The high degree of sequence similarity between
the CTE-I and MTE-I genes suggests that they diverged
relatively recently by gene duplication, poss...
Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... key enzyme hydrogenase, which is
synthesized only after an anaerobic adaptation, catalyzes
the reversible reduction of protons to molecular hydrogen.
Hydrogenases are found in nearly all taxonomic ... of
anaerobic microbes, where they often catalyze the reduction
of pr otons with a high specific activity to yield hydrogen
[16]. Interestingly, Fe-hydrogenases were not found in
cyanobacteria, th...
Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt
... J.O., Whang-
Peng,J.&Haynes,B.F.(1984)Conversionofastemcellleukemia
from a T-lymphoid to a myeloid phenotype induced by the ade-
nosine deaminase inhibitor 2¢-deoxycoformycin. Proc. Natl Acad.
Sci. ... decreased, while megakaryocytes,
granulocytes and monocytes appear to be normal.
The v-Myb gene, transduced by avian myeloblastosis
virus (AMV), is an oncogene that specifically blocks
termi...
Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx
... activity was
dramatically diminished. Alternatively, hTR and hTERT
may play a minimal catalytic activity in telomerase, while
the assembly of other telomerase subunits may amplify the
enzyme function. ... amplification protocol-enzyme immunoas-
say (TRAP/EIA) as described previously [27]. Telomerase
activity was determined by the ability to produce telomere
repeats by a PCR-based TRAP assay an...
Báo cáo y học: "Transcription profiling of rheumatic diseases" doc
... Fibroblast-
like synoviocytes derived from patients with rheumatoid
arthritis show the imprint of synovial tissue heterogeneity:
evidence of a link between an increased myofibroblast-like
phenotype and ... microarray
technology has provided a powerful tool to gain insight into the
molecular complexity of these diseases; this technology facilitates
open-ended survey to identify comprehensively...
Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
... immunity
IL-6 is a pro-inflammatory cytokine that has a progressive
function in many inflammatory diseases, whereas IL-10 is an
immunoregulatory cytokine that has potent anti-inflammatory
activity. ... & Therapy June 2005 Vol 7 No 3 Yoshimura et al.
Abstract
Immune and inflammatory systems are controlled by multiple
cytokines, including interleukins and interferons. Many of these
cy...
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