Báo cáo y học: "Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices" pptx

... Kyle Kolaja (Iconix Pharmaceuticals, Mountain View, USA) explained the potential of the company’s DrugMatrix, a pro- prietary chemogenomics database that incorporates informa- tion from animal studies, ... and phar- macokinetic properties, and lowered their cost. Finally, John Maraganore (Alnylam Pharmaceuticals, Cam- bridge, USA) discussed therapeutic applications of RNAi, as exem...

Ngày tải lên: 14/08/2014, 14:21

... interpreted the data, and drafted the manu- script. MFG and KBL assisted with data interpretation. All authors read and approved the final version of the manu- script. Additional material Acknowledgements HBM ... subsidised by Medicare, a universal healthcare system financed through income tax and an income-related Medicare levy. Governed by the Australian Health Care Agreements...

Ngày tải lên: 10/08/2014, 21:23

... percentage stance times of 0 and a gait symmetry variable of approximately 0.5. A shift in either of these variables would indicate a shift away from balanced, symmetric gait. For the statistical ... early stages of lumbar radiculopathy in the rat, and that, gait metrics and dynamics may be valuable measures in pre-clinical studies evaluating drug effectiveness. Abbr...

Ngày tải lên: 12/08/2014, 17:22

... larval A- class (LA), and embryonic A- class (EA) microarray datasetsEnriched genes from the larval pan-neural (LP), embryonic pan-neural (EP), larval A- class (LA), and embryonic A- class (EA) microarray ... dataset were selected on the basis of statistical rank. RNA amplification and microarray data analysis A C. elegans Affymetrix chip was used for all microarray experiments [1...

Ngày tải lên: 14/08/2014, 07:22

... Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tom- ida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T: A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances ... constructs (a) (b) 0 0.5 1 1.5 2 2.5 3 APBB2 -A APBB2-B APBB2-C APP -A APP-B APP-C APP-D BCL2L11 -A BCL2L11-B BCL2L11-C BCL2L11-D BCL2L11-E CCND1 -A CCND1-B CCND1-C CCND1-D CCND2 -...

Ngày tải lên: 14/08/2014, 20:22

... however, abundantly glycosylated and the apparent molecular mass on SDS/PAGE has been estimated to 120±140 kDa [11,12]. Human BSSL has a unique primary structure as compared to other mammalian lipases. ... for secretion of rat pancreatic BSSL [15]. On the other hand, we and others have shown that t he repeats are completely dispensable for the typical functional properties of BSSL...

Ngày tải lên: 24/03/2014, 03:21

... what is being called the “French-Canadian AID mutation.” The patient was referred to our clinic at the age of 16 years. He had had chronic cervical lym- phadenopathy since the age of 2 years and ... happened to carry the rare allele. If the new population remains isolated as it expands, as has been the case in parts of Quebec, and especially if there is inbreeding, as was...

Ngày tải lên: 08/08/2014, 21:20

... non-digested DNA. The major advantage of the RSTA system is that it pro- duces highly accurate genotypes of individuals at many loci simultaneously without ascertainment bias. Other platforms can provide ... affordable, species- specific microarray. The RSTA array approach can be applied to any species with a cDNA library database or 454 transcriptome sequence, for example. A co...

Ngày tải lên: 09/08/2014, 20:21

... of attenuator regulation in each gene family through a systematic literature survey and comparison to the Rfam RNA family database [38] and to the RegulonDB database of E. coli transcriptional net ... also act as a terminator hairpin. The analysis of such a multiple paralog family raises interesting evolutionary questions on the origin of associated attenuators, that is,...

Ngày tải lên: 09/08/2014, 22:23

... Teatinos s/n. Malaga, 29071 Malaga, Spain. 2 Department of Basic Psychology, University of Malaga, Malaga, Spain. 3 Department of Basic Psychology, Complutense University of Madrid, Madrid, Spain. 4 Department ... Treatment, Psychology Faculty, University of Malaga, Campus de Teatinos s/n. Malaga, 29071 Malaga, Spain Full list of author information is available at the end of...

Ngày tải lên: 11/08/2014, 15:22