Báo cáo y học: "The rarity of gene shuffling in conserved genes" pptx

... properly cited. The rarity of gene shuffling in conserved genes<p>The incidence of gene shuffling is estimated in conserved genes in 10 organisms from the three domains of life. Successful gene ... example, duplication of domains within a gene. In such a gene shuffling event, the parental genes may be either destroyed or pre- served [6]. Gene shuf...

Ngày tải lên: 14/08/2014, 14:21

... normally express the gene of interest. The advantage of using the BAC as a cloning vector is that it can carry as much as 200 kb of genomic DNA - typically enough to include most, if not all, of ... recombinase (Figure 1). These lines can then be bred with other lines of mice whose genomes are engineered to contain genes surrounded by loxP sites, resulting in a recombinant strai...

Ngày tải lên: 14/08/2014, 07:21

... of inversions Proportion of gene pairs still as neighbours Differences in intergene distanceFigure 2 Differences in intergene distance. Intergene distances of gene pairs currently in synteny ... are unique in having no promoter sequence in the intergene spacer. This might in part explain why in many cases a further regularity appears, namely that gene pairs currentl...

Ngày tải lên: 14/08/2014, 08:20

... glutathione (GSH) are ma intained by two s ystems. One is de novo synthesis from b uilding blocks, glutamate, cysteine, and glycine, via two ATP-con suming s teps involving c-g lut- amylcysteine synthetase ... transit proteins during spermio- genesis, is rich in both arginine and cysteine. The cysteine sulfhydryls in protamine must form disulfide bond to package DNA into small sperm head d...

Ngày tải lên: 17/03/2014, 17:20

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this ... ternary com- plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to prime substrate oxidation. In the case of DAOCS it has been pr...

Ngày tải lên: 18/03/2014, 01:20

... a patient who likely has a lymphocytic variant of hypereosinophilic syndrome that resulted in eosinophilic infiltration of the gastroin- testinal tract, sinuses, and airway that contributed to variable ... unique association of eosinophilic gastrointestinal disease with eosinophilic bronchitis, asthma and chronic rhinosinusitis and some features of lymphocytic hypereosinophilic synd...

Ngày tải lên: 08/08/2014, 21:20

... disorders in a National Community Sample: findings from the National Comorbidity Survey. Psychother Pychosom 2004, 73:235-242. Annals of General Psychiatry 2009, 8:1 http://www.annals-general-psychiatry.com/content/8/1/1 Page ... higher number of females than males in the study was likely to be an illustration of attendance patterns, mainly at general hospitals although this finding...

Ngày tải lên: 08/08/2014, 23:21

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... and equally efficacious in man- aging inflammation. However, whereas the selectivity of this group of compounds might allow inflammation to be inhibited with minimal effects on certain h...

Ngày tải lên: 09/08/2014, 01:21

... investigation of pathways that lead to disease, well into the future. Introduction The history of genome-wide mapping of disease-causing genes began in 1980, when linkage analysis by use of anony- mous genetic ... [87,88]. Outbred strains have high-density recombinations that can allow mapping to subcentimorgan levels in one generation, by combining the advantages of association...

Ngày tải lên: 09/08/2014, 01:22

... [18]. The microarray assay used (Panorama Cytokine Gene Array membranes; Sigma Genosys, Inc) included 375 genes enriched in cytokines, chemokines, cell surface 286 ably derive from studies of tissue samples ... reasonable sampling of those gene pathways that are activated and relatively disease specific. Conclusion Since the dramatic illustration of the clinical utility of micro...

Ngày tải lên: 09/08/2014, 01:23