Báo cáo y học: "Making sense of nonsense: the evolution of selenocysteine usage in proteins" ppsx

... Apparently, if paralogous TFs maintain overlap- ping DNA binding specificities, then a single site can evolve to bind both TFs. As the evolution of these sites relies on the functional similarity of the ... that relatively few of the TFs evolved by duplications within the E. coli lineage. Instead, we found a surprisingly complex history of HGT for many of the regulator...

Ngày tải lên: 14/08/2014, 08:20

... specific and gained their housekeeping status later in the evolution of the primate lineage. If Alus are merely accumulating in flanking regions of housekeeping genes, then we would expect them to be ... simply as enrichment in GC-rich domains. We find that the enrichment is best explained as being in the vicinity of housekeeping genes. Is it the case, then, that Alu...

Ngày tải lên: 14/08/2014, 08:20

... topology [2,3], meaning that the majority of nodes show a low degree of connectivity and the topology of the network is dominated by a small fraction of highly connected nodes. Another prop- erty of metabolic ... analysis shows that this increase is mainly due to enzyme-enzyme interactions. In fact, the fraction of non- enzymatic duplicates, mainly comprising protein com...

Ngày tải lên: 14/08/2014, 17:22

... surprisingly, selA is similar to selenocysteine ␤-lyase, the enzyme that catalyzes the back-reaction of selenocysteine synthesis. Perhaps the most interesting evolutionary question for selenoprotein ... and not others? What are the forces driving the evolution of selenoproteins? In which direction is the evolution going - are animals in the process of phasing o...

Ngày tải lên: 14/08/2014, 14:21

... should be incapable of re-innervating the joint. In this study we investigate the long-term effi- cacy of facet debridement for the treatment of chronic back pain originating in the facet joint. ... guidance, the facet joints are identified. An incision of between ½ to ¾ of an inch is made in the skin at the entry site. A guide wire is inserted down to the...

Ngày tải lên: 26/10/2012, 09:32

... aimed to evaluate the efficacy of endoscopic laminoforamino- plasty (ELFP) in the treatment of thoracic radiculopathy. Methods: Twelve patients with radicular pain involving the lower thoracic ... endoscopic laminoforaminoplasty via a small incision, of less than one inch. Materials and Methods Twelve patients were treated with endoscopic laminoforaminoplasty (ELFP) of...

Ngày tải lên: 26/10/2012, 09:57

... may therefore be indicative of infection and their response to inflammation. Further evidence for this was the dose- dependant increase in shedding of HL-60 HLA-DR upon incubation with the inflammatory ... mentioned otherwise]. Both the percentage of cells expressing HLA- DR on monocytes and the density of HLA-DR was measured. Immuno-fluorescent microscopy of HLA-DR in...

Ngày tải lên: 03/11/2012, 09:57

... regulatory protein, arrestin, binds with high affinity to the phosphorylated receptor to sterically inhibit the interaction of the receptor with G protein, resulting in the shutting-down of the downstream ... apparently close from the viewpoint of the amino acid sequence similarity and the position of the intron to the vertebrate type of arrestin (Fig. 1). There...

Ngày tải lên: 31/03/2014, 08:20

... anaphylaxis showed that delayed or no administration of epinephrine was a factor in many of the deaths [2]. Similar trends were seen in US mortality data recorded by the American Academy of Allergy, ... that quality of life can be severely affected by food allergies in terms of restriction of social activities, increased fear and anxiety, lack of understanding by other...

Ngày tải lên: 08/08/2014, 21:20

... drawing the solution into the syringe. Before removing the needle from the vial, pull the plunger all the way back to the end of the syringe barrel in order to remove all of the solution from the ... the patie nt and the healthcare professional of the continu ed risk of anaphylaxis. Should patients be unwilling to remain in clinic for the physician-reco...

Ngày tải lên: 08/08/2014, 21:20