Báo cáo y học: "Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences" pps

... Genome Biology 2005, 6:P8 Deposited research article Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences Yi Xing and Christopher ... suggest that alternative splicing reduces amino acid selection pressure, even for alternatively spliced exons that are functional, while simultaneous...

Ngày tải lên: 14/08/2014, 14:21

... frequently used to treat this syn- drome. However, patients with treated with antipsychotic drugs should be monitored for a variety of adverse events, including hypotension, dystonia, extrapyramidal ... Annals of General Psychiatry 2010, 9:18 http://www.annals-general-psychiatry.com/content/9/1/18 Page 2 of 4 Given the important role of sigma-1 receptors in the regulation of neu...

Ngày tải lên: 08/08/2014, 23:21

... Annals of General Psychiatry 2010, 9:28 http://www.annals-general-psychiatry.com/content/9/1/28 Page 2 of 3 remains anonymous and there is no reason to think that the patients or their family would ... contribution of these hypnotics on the efficacy of fluvoxamine for delirium. A further study of fluvoxamine alone will be necessary. Delirium is theorised to be a neurobehavioural...

Ngày tải lên: 08/08/2014, 23:21

... be suboptim al for use with diseases resulting from consan- guinity, for which filtering by homozygosity by descent would be more effective than filtering by identity by des- cent. Finally, several ... Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA. 3 Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA 52242...

Ngày tải lên: 09/08/2014, 23:20

... post-operatively. Nerve graft- ing is a useful procedure for restoration of flexion of the elbow joint, but motor reinnervation comes later than in Forty months after surgeryFigure 3 Forty months after ... atrophy of the muscle occurs. In adult, Leechavengvongs et al. [2] performed partial ulnar nerve transfer for thirty-two patients with brachial plexus palsy. They reported that...

Ngày tải lên: 10/08/2014, 09:22

... its activity to the activity of Exon2-luc in transient transfection assays. The mutation led to complete loss of activity in these assays, indicating that the integrity of the AUG is crucial for translation ... We therefore concluded that a protein is expressed from the E2F6b mRNA. Our results suggest that translation of Exon2-luc is initiated internally. Alternatively, it i...

Ngày tải lên: 08/03/2014, 09:20

... significantly reduce migra- tion of these cells, suggesting that the loss of p21 in FLS may enhance their ability to migrate towards the proinflammatory constituents of the RA joint. Recently, Besson ... the pre- vious study employed fibroblasts derived from an embryo. The previous study examined cell migration by wounding of a con- fluent monolayer of cells, whereas our study exa...

Ngày tải lên: 09/08/2014, 08:22

... effect may in part be mediated by selection for mRNA stability. Notably, the preference for cytosine at synonymous sites can be accounted for by such a process. Importantly, the observed substitutions ... 3). Cytosine preference at synonymous sites, diagnostic of selection, can be explained by selection on mRNA stability While the above results suggest that the identity of t...

Ngày tải lên: 14/08/2014, 14:22

... antifreeze activity (Fig. 2). Equimolar solutions of deglycosylated and untreated smelt AFP displayed similar faceted ice crystal morphology (Fig. 2). The antifreeze activity of the untreat- ed and d eglycosylated ... morphology signifies the presence of antifreeze activity. The rounded ice crystal formed in the control sample c ontaining only N-glycosi- dase F shows that the enzyme do...

Ngày tải lên: 24/03/2014, 03:21

... mgÆmL )1 of AZT for 15 days. In H 2 O 2 treatment, cells were incubated with 0.01 m M of H 2 O 2 for 4 h everyday for a period of 25 days. Cells were maintained with or without NAC for an additional ... directly impair the energy-producing system of mitochondria, causing dysfunction of cellular redox control, which eventually leads to loss of the mitochondrial DNA integrit...

Ngày tải lên: 24/03/2014, 04:21