Báo cáo y học: "Quantitative genomics of starvation stress resistance in Drosophila" pps

... properly cited. Quantitative genomics of starvation stress resistance in Drosophila<p>The efficacy of transcriptional profiling for identifying networks of pleiotropic genes regulating complex ... recombi-nation breakpoint is not determined, and gold if the genotype is unknown because of residual heterozygosity in the RI line. The results of Tukey tests separating...

Ngày tải lên: 14/08/2014, 14:21

... in 2003. The lines were inbred by 20 generations of full-sib inbreeding to create 340 inbred lines. Locomotor reactivity for each of the inbred lines was measured by randomly assigning the lines ... underlying genetic complexity of locomotor behavior in Drosophila. The neurotransmitters serotonin (5-hydroxytryptamine) [13], octopamine (the invertebrate homolog of noradrenaline) [1...

Ngày tải lên: 14/08/2014, 08:20

... studying DNA damage Early studies using DNA microarrays indicated that transcrip- tional responses often reflect underlying biology: for instance, the expression of cell-cycle genes that cycle in ... are beginning to have an impact on many areas of yeast biology. Two recent studies, using different experimental platforms, provide insight into new pathways involved in the response of...

Ngày tải lên: 14/08/2014, 17:22

... improvements in social inte- gration, professional skills, and the quality of interpersonal relationships following intervention [2]. Increasingly, symptom remission and ultimately recovery are advocated ... importance of measuring psychosocial functioning in schizophrenia. Annals of General Psychiatry 2011 10:18. Brissos et al. Annals of General Psychiatry 2011, 10:18 http://www....

Ngày tải lên: 09/08/2014, 01:21

... suppresses IL-1-induced glycosamino- glycan release from cartilage by inhibiting ADAMTS, MMP-1 and MMP-13 expression through preferentially blocking NF-κB activity in chondrocytes. EGCG also inhibits ... oncostatin M-induced JAK/ STAT pathway in human chondrocytes [13]. It promotes chondrogenesis from mesenchymal stem cells by antago- nizing proinfl ammatory cytokines [14]. Despite the...

Ngày tải lên: 12/08/2014, 15:22

... example of how CRM finding can precede motif-finding in cis-regulatory analysis, rather than rely on prior knowledge or discovery of the motifs. A thorough inves- tigation of this claim, using many ... the input sequences in sliding windows of a fixed length. It scores each such win- dow by its likelihood of being generated by a certain probabi- listic model parameterized by the...

Ngày tải lên: 14/08/2014, 08:20

... an animal dying at day 4 had survival scores of [0 0 0 1]. The model and Bayesian setup is described in more detail by Ødegård et al.[19]. Here, the probability of an individual i being censored ... are back-truncated to a point in time where mortality is still increasing. In a simulation study, it was concluded that if selecti on aims at improvi ng susceptibility the error of app...

Ngày tải lên: 14/08/2014, 13:21

... of rhinitis, eosinophilia and expression of several cytokines [2,5]. Materials and methods Nasal biopsy samples were obtained as a part of a pre- viously published clinical study [2]. Briefly, ... primary antibody. Represen- tative pictures were recorded prior to destaining the slides of hematoxylin with 1% HCl in 70% ethanol. The hematoxylin destained samples were assessed in a b...

Ngày tải lên: 08/08/2014, 21:20

... diversification of their glycomes. N-linked glycosylation Protein N-glycosylation, the most prevalent and highly conserved type of protein glycosylation, is initiated in the rough endoplasmic reticulum of ... mucin-type O-glycosylation in animals [62]. Glycophosphorylation o f the hydroxya- mino acids threonine and serine may be less prevalent in D. purpureum owing to the much sma...

Ngày tải lên: 09/08/2014, 22:23

... cells treated with increasing amounts of formaldehyde identified lysine acetylat ion marks on histone H3 lysine 9 a nd lysine 14 (H3K9acK14ac) and histone H4 lysine 12 and lysine 16 (H4K12acK16ac). ... chemical cross-linking needed to trap protein-protein and protein-DNA interactions, while still allowing for the solubility of chromatin for purification and access of affinity reagents [...

Ngày tải lên: 10/08/2014, 09:22