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Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf

Báo cáo y học:

Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf

... used to obtain DNA-microarray data of improved quality. A novel scheme to assess factors involved in the reproducibility of DNA-microarray data Running title: a novel scheme to assess ... data quality. In order to assess the reproducibility of- and factors involved in DNA-microarray data produced in our laboratory during transcriptome analyses by a number of researchers, a validation ... [10-13]. In the process from manufacturing DNA-microarrays to performing the actual experiments, systematic errors and / or bias in the data are introduced in each of the different steps. The effects...
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Báo cáo y học:

Báo cáo y học: "A novel approach to identifying regulatory motifs in distantly related genomes" pps

... summarized by their motif name (in bold), by their consensus sequence, if known, as described in the original article, by the sequence of the motif instance in our search, by the positions of the motif ... article, by the sequence of the motif instance in our search, by the positions of the motif instance relative to the consensus sequence of the entire block and by the strand (indicated by a '+' ... summarized by their motif name (in bold), by their consensus sequence, if known, as described in the original article, by the sequence of the motif instance in our search, by the positions of the motif...
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Báo cáo y học:

Báo cáo y học: "A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis" pptx

... stoichiometric binding of protease inhibitors to the catalytic site of the activated forms of the enzymes. In the present work, we have measured by flow cytometry the netproteolytic activity ... surprising since the levels of MMP-9 in SF have beenshown to vary according to several factors, such as the dis-ease state, the local concentration of inflammatory cytokines,and the number of infiltrating ... diversity of the repertoire of active MMPs in arthriticSF. Although the identity of the specific MMPs involved in dif-ferent types of arthritis remains to be determined, from a clini-cal point of...
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Báo cáo y học:

Báo cáo y học: "A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens" pptx

... shown in Fig 1C, phages displaying the DSPpeptide specifically bind to a synthetic biotinylated TMGpeptide (Fig. 1C, TMG). Conversely, phages displaying the TMG peptide bind to a synthetic biotinylated ... chaperon-ing peptides into the antigen processing pathway of iDC,may also trigger IFN-γ production in a similar way to that of LPS [46-49]. These findings are in agreement with pre-vious data showing ... Bond*†1Address: 1Moyne Institute for Preventive Medicine, Department of Microbiology, University of Dublin, Trinity College, Dublin 2, Ireland, 2Institute of Immunology & Department of Biology, National...
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Báo cáo y học:

Báo cáo y học: "A novel approach to sonographic examination in a patient with a calf muscle tear: a case report" docx

... clinic complaining of left calf pain. He visited ourclinic 10 days after the sudden onset of pain at the leftmedial aspect of the posterior calf during rigorous steepmountain climbing. In ... 90 degrees. The transducerwas now pointing upwards to examine the calf muscles.(B) Longitudinal US image examined approximately 17 daysafter the initial injury revealed a well-defined anechoicfluid ... all the fluid into one place, which can assist in the viewing of the fluid accumulation at the lesion site using US.Although we have reported only one case, this study mayoffer the crucial information...
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Báo cáo y học:

Báo cáo y học: "A novel approach to modelling water transport and drug diffusion through the stratum corneum" pdf

... fixing the value of z within the restrictions imposed by the dimensions of the inter-cellular channel.We f ixed the value of the height of the superimposed solutions to be at the middle of the intercellular ... whereas the ver-tical boundary conditions are considered to be of the n o-flux type, to represent the symmetry of the linear flow. We are now able to plot a cross-section of the solution,by fixing ... is the study of the physical properties of the Stratum Cor-neum (SC), which constitutes the uppermost set of skin layers. The SC’s main functionis providing a barrier against the loss of physiologically...
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Báo cáo toán học:

Báo cáo toán học: " A novel algorithm to form stable clusters in vehicular ad hoc networks on highways" doc

... receiving this message by setting theircluster ID temporarily to be the ID of the COV as shown in line 3. Vehicles start calculatingtheir suitability to become a CH as shown in line 4. Then, the ... onlyr-stable neighbors of the winner (since the cluster boundary is defined by r), which belong to the Γ(t) of the COV change their state to a CM and change their temporary cluster ID to be the Page-13control ... according to the following criteria:• The suitability value of the vehicle is calculated by considering the mobility information of its stable neighbors only.• Nodes having higher number of stable...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc

... thrombin–FXIinteraction. The only assumption made was that the value of the asymptotic parameter V¥corresponds to the velocity of the substrate hydrolysis by the FXIa concentration equal to the ... activation loop at the N-terminus of the catalyticdomain, are notable. In the zymogen FXI, Ile371 is exposed to the solvent, while in the activated FXI it is inserted into the protein. The picture ... the mutation to the cleavage site, probably resulting in asmall interference with the binding of the activator to the FXI zymogen.There are some examples of inherited coagulationdisorders in which...
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Báo cáo hóa học:

Báo cáo hóa học: " A novel adenovirus vector for easy cloning in the E3 region downstream of the CMV promoter" pot

... firstcloning step into a shuttle plasmid containing a promoterfor the expression of the transgene. After selection of recombinants, the plasmid DNA of each clone has to betransferred into an other ... reducing considerably the time of selection and, of course,production of the corresponding vectors. Using this vector, we produced recombinantadenoviruses, each giving high-level expression of the ... template, and sequentially clonedon either side of the CMVp in pcDNA3 to give the pLeft/Right plasmid. Thereafter, annealed oligonucleotides,containing the TCS, were inserted into the BamHI/NotIopened...
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Báo cáo y học:

Báo cáo y học: "A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat" pptx

... prekallikrein(PK) to the surface of endothelial cells and leukocytes [7], gen-erates the enzyme kallikrein. Kallikrein in turn cleaves HK to yield the inflammatory mediators bradykinin (BK) and ... wasobtained from the left atrium as the heart beat. The sample of 3 to 5 ml was obtained by slow vacuum (to prevent hemolysis)within a minute (to prevent clotting in the syringe). The bloodwas then ... high-molecular-mass kininogen to leukocytes and endothelial cells in the HLA-B27 rat, which was administered after the onset of the inflammatory changes. Thrice-weekly intraperitoneal injections of monoclonal...
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