Báo cáo y học: " Who owns the data" pot

... Society. The way itworks is simple. Others may commercialize products basedon the procedure. But any improvements in the technologymust be shared freely, to the benefit of all users. The intent ... are any indication, this isnot an idea that’s going to go away any time soon. Who owns the data? Increasingly, at least for some things, the answer is starting to be nobody. Or everybody. commentreviewsreportsdeposited ... patent on the technology, whichthey call TransBacterTM. But they are offering this technol-ogy as an ‘open-source’ alternative to At technology, which iscontrolled by Monsanto, the large...

Báo cáo y học: "Repolarization of the action potential enabled by Na+ channel deactivation in PSpice simulation of cardiac muscle propagation" ppt

... propagation velocity becameextremely fast, i.e. non-physiological. The after-hyperpolarization produced following the polarization of the AP (e.g. see Fig. 2), equivalent to the physiological hyperpolarizing ... caused the PSpice program to become veryerratic and unstable. Therefore, only the rising phase of the APs was simulated. This defect in the program wasacceptable since only the mechanism(s) for the ... one cell to the next was under investiga-tion; for this purpose, only the fast rising phase of the APwas necessary. The purpose of the present study was todetermine whether another method...

Báo cáo y học: "Termites in the woodwor" potx

... biochemical analysis of some of the enzymes theydiscovered. The team began by sampling the luminal contents of the P3hindgut segment, pooling the material from 165 adultworker termites. This is the largest ... dominated the community.Notably, Warnecke et al. [3] did not detect any archaealsequences, nor did they find much eukaryotic material(there was apparently very little contaminating DNA from the ... any). They discovered 216 distinct 'phylotypes' ofbacteria (that is, groups of 16S sequences with at least 99%sequence identity) and estimated from the redundancy inthese phylotypes...

Báo cáo y học: "Closure of the NCBI SRA and implications for the long-term future of genomics data storage" doc

... before ﬁnally being deleted.RK: If there is a good chance that the data are going to be used by others, then yes, there is a good case for storing them. Just storing the raw data for the sake ... we rely on it maybe more than others. We download data reasonably frequently, but because of the size of the datasets we try not to do it too often.RK: e SRA was widely disliked by a lot ... the University of Colorado).1. Why did the SRA close? How widely used by the community was it?DL: NCBI was facing budgetary constraints and presented a range of options to the National Institutes...

Báo cáo y học: "Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study" potx

... to test the hypothesis that hyperuricemia is associated with coronary arterycalcification (CAC) among a relatively healthy population, and that the extent of calcification is directly proportionalto ... model. The second objective of the analyses was to test the hypothesis that, among those with CAC, Agatstonscores will be directly proportional to sUA concentra-tion. The distribution of these ... In the INSIGHT (International Nifedipine Study Interventionas Goal for Hypertension Therapy) study, in which CACwas measured in hypertensive patients who were olderthan 55 years of age and who...

Báo cáo y học: "Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data" potx

... stability values. (d) The percentage of transcripts likely to be regulated by miRNA (y- axis) for the transcripts encoding the highly ordered and the highly disordered proteins. (e) The percentage ... being removed from the cell, asthey are likely to have a higher density of ubiquitination sites. The (80,100]% disorder category is most likely to have the highest density of ubiquitination ... and enzyme inhibitors thatreduce the activity of proteases (that is, enzymes catalyzing the hydrolysis of peptide bonds) (Table 4).Protein disorder, mRNA decay rates and protein stability indicesThe...

Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"

... step forwards to assess the utility of thesequestionnaires in another practice setting.Therefore the aim of this observational study was toassess the utility of the MYMOP2 and W-BQ12 healthoutcomes ... utilised for the study.Patients were invited to participate in the study if theywere: over the age of 18 years; had no treatment fromany health professional for their complaint in the preced-ing ... other than the Activity scale of the MYMOP2 which had no significantcorrelations with any of the W-BQ12 scales (see Table 3).MYMOP2hasbeenshowntobehighlyresponsivetochanges in symptoms whether...

Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"

... with great bravery to return to the clinicand to obtain their medication refills.▪ Patients really surprised us. They walked distances, theyran away, they tried again, they came back. I remember ... them to go on the roads and try toget [to clinic]. The risks to personal safety were seen to vary based on the fam-ilies' tribal affiliation, their location, and whether they were in the ... dif-ficulty returning to care. Younger children may have beenat greater distances from the clinics than older childrensince they were described as being "like another luggageyou carry on your...

Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"

... 5. de Godoy JM, de Godoy Mde F. Physiopathological hypothesis of cellulite. Open Cardiovasc Med J. 2009;31(3):96-7. 6. Godoy JMP, Almeida EMMZNM, Silva SH, Godoy MFG. Pilot study of the intensive ... until the edema is controlled. Another important aspect to be analyzed is the assessment of all changes that may lead to tissue ac-cumulation such as in obesity, lipedema and lymphedema; the ... specifically in relation to edema. The observation of cyclic edema demonstrated the success of the treat-ment and the need for its control, but we had no idea of the high prevalence of edema in the...

Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"

... components by use of the inverse Diels Alder technology. The high chemical stability and the ease of synthesis qualify these polyamide building blocks as favourites for intracellular delivery and ... Germany. The synthesis of the Reppe Anhy-dride was carried out as documented by Reppe [16]. The reaction to tetracy-clo-[5.4.21,7.O2,6.O8,11]3,5-dioxo-4-aza-9,12-tridecadiene 4-yl acetyl ... 5-dansyl sulfamidoethylcarboxamide-2-yl. 4. For the syntheses of the polyamide-based pentamers I-III (Figure 3, Figure 4) and the heptamer (the ligation product 15 is shown in Figure 7) the...

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