Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx
Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx
... properly cited. Detection of quantitative trait loci with estimates of gene expression.<p>The use of recombinant inbred lines allows an estimate of the heritability of expression measured by ... heritability for detection of quantitative trait loci with microarray estimates of gene expression Kenneth F Manly *†‡ , Jintao Wang † and Ro...
Ngày tải lên: 14/08/2014, 14:21
Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... in levels of aggrecan and type II collagen mRNA by TNF-α, by EGF or by TNF-α + EGF. Activation of PKC thus does not appear to be involved in the regulation of matrix gene expression by TNF-α and ... expression of cytokines and chemokines by synovial cells and chondro- cytes, thereby sustaining a renewal of local inflammatory mediators (reviewed in [9,10]). The presence...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect" pdf
... group. Figure 2 In vivo analysis of cartilage repair by synovial mesenchymal stem cell transplantation in rabbitsIn vivo analysis of cartilage repair by synovial mesenchymal stem cell transplantation ... Kenichi Shinomiya, MD, PhD, for continuous support, Miyoko Ojima for expert help with histology, and Alexandra Peister, PhD, for proofreading. The present study was supporte...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Is research working for you? validating a tool to examine the capacity of health organizations to use research" doc
... expressed here are those of the authors. Publication does not imply any endorsement of these views by either of the participating partners of the Community Health Research Unit, or by the Canadian Health ... statisti- cally significant for 13 of the 27 items individually rated, and for five of the 27 items rated by consensus. No con- sensus scores were significantly di...
Ngày tải lên: 11/08/2014, 05:21
Báo cáo y học: "Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inh
... anti-inflammatory properties of nonsteroi- dal anti-inflammatory drugs (NSAIDs) are based on the inhibition of the cyclooxygenase (COX) enzyme isoforms [6]. Traditional NSAIDs inhibit both isoforms of the ... first level of health care are treated by specialists in family medicine or by general practition- ers with several years of clinical experience. If a patient cannot cont...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: "An improved method for detecting and delineating genomic regions with altered gene expression in cancer" ppsx
... [26] of expression profiles of childhood acute lymphoblastic leukemias (ALL). The elements indicate the numbers of cases of each leukemic subtype, as defined by cytogenetic and molecular genetic ... comparison with the intrinsic variability in gene expression. Third, the expression of some genes may not be influenced by the underlying genomic change. For example, copy num...
Ngày tải lên: 14/08/2014, 08:20
Báo cáo Y học: DNA supercoiling in Escherichia coli is under tight and subtle homeostatic control, involving gene-expression and metabolic regulation of both topoisomerase I and DNA gyrase docx
... lacI q1 gene are surrounded by a DNA fragment originating from upstream the gyrA gene and a fragment containing the N-terminal part of the gyrA gene. To create a plasmid for integration of the lac-type ... study the regulation of cell function both comprehensively a nd fairly quantitatively. Yet it is of crucial importance to evaluate how much of a given regulation is effec...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf
... process [11]. Recently, it was shown that regulation of the rat cholinergic gene locus by cyclic AMP is mediated by PKA type II, but not by PKA type I [12]. In a previous study, we demonstrated ... acetyl coenzyme A is catalyzed by the enzyme choline acetyltransferase (ChAT, acetyl-CoA:cho- line O-acetylotransfe rase, EC 2.3.1.6) [1]. Following syn- thesis, ACh is transported into...
Ngày tải lên: 31/03/2014, 21:21
Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
... inflammatory disease characterized by the infiltration of the synovial membrane with monocytes/T cells, by the proliferation of synovial lining cells and by the production of proinflammatory cytokines, which ... Maloney W, Osdoby P: Receptor activator of NF-kappa B and osteoprote- gerin expression by human microvascular endothelial cells, regulation by inflammatory cytokin...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu." pptx
... susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension. Hypothesis: We hypothesized that an elevated systemi c proinflammatory burden correlates with dysglycemia ... the group with prediabetes: table 2) of an unregulated systemic proinflammatory milieu (clinical correlate: Figure 1 Systemic Proinflammatory Mileu in Disease Free Normoglycemic...
Ngày tải lên: 11/08/2014, 06:22