Báo cáo y học: "Large-scale discovery and validation of functional elements in the human genome" ppt

... goal of identifying all the functional elements in the human genome. The functional elements discussed at the meeting included protein-coding genes, reg- ulatory elements, RNA genes and DNA sequences ... [http:// www.genome.gov/10005107]. The consortium, organized and funded by the National Human Genome Research Insti- tute, is initially focusing on designated...

Ngày tải lên: 14/08/2014, 14:21

... expression only of GAD67, a gene controlling the synthesis of GABA [2]. A striking increase in gene expression levels of GAD67 was observed in the large and small airway epithelium of healthy smokers ... only in the brain, but also in other organs, including liver,kidney,pancreas,testis, oviduct, adrenal, and lung [3,4]. GABAergic System in the Lung In the lu...

Ngày tải lên: 12/08/2014, 11:22

... leaks in the air-handling and sys- tem components after assembly of the NBIES. Leaks detected (if any) were sealed and the system repeatedly retested to verify remediation. To improve safety and extend ... process on the viability of the entrained agent in the impingers can only be inferred, collection efficency of our sampling system using funda- mental mathematic...

Ngày tải lên: 12/08/2014, 04:20

... study was supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to YN, KU-T, KS, and YT), the Ministry of Health, Labour and Welfare of ... con- tains the siRNA target site was cotransfected into HeLa cells with the corresponding siRNA, and the mRNA cleav- age activity of the siRNA was evaluated by measu...

Ngày tải lên: 13/08/2014, 05:22

... t influence on the prevalence of hyperopia and myopia. As age increased, the prevalence of hyperopia signif- icantly decreased and the prevalence of myopia in - creased. Based on the definitions ... China, especially the de- veloping regions. Western China is very vast (6.8 million square kilometers, accounting for 71% of the area in main- land China), and in...

Ngày tải lên: 25/10/2012, 11:40

... quantification of axonal boutons afforded us a higher sensitivity in detecting differences in the present study. In the context of our finding, it is interesting to note that, a single polymorphism in the ... furnished by other pyramidal neurons, located both within the PFC and in other cortical areas [10-12]. The integrity of PFC functions therefore depends on th...

Ngày tải lên: 11/08/2014, 17:20

... waterfowl. With the purpose of decreasing economic losses in the commercial duck industry, studying the unknown glycoprotein K (gK) of DEV may be a new method for preferably preventing and curing this ... entry of free viruses, and the maturation or egress of the virus [8,9]. Glycoprotein K is one of the major glycoproteins encoded by the DEV-gK gene, which is lo...

Ngày tải lên: 12/08/2014, 01:21

... have helped in drafting and finalizing the manuscript and pro- vided important input on the design of the study. BB con- ceived the study, participated in its coordination, and helped in drafting the ... 3' end of the ASP ORF and were likely determinant for the polyadenylation of the antisense tran- script [4]. We next searched for the 3' end o...

Ngày tải lên: 13/08/2014, 05:22

... studies of Mosimann et al. [12], the hydroxyl group of Tyr179 lies within hydrogen-bonding distance of O7 and O9 of the glyceryl moiety of Neu5Ac, and a network of noncovalent bonds between enzyme and ... con- structed and the kinetic parameters of the purified F192A and F193A mutant enzymes were obtained in the same way as the wild-type enzyme (Table 1)....

Ngày tải lên: 22/03/2014, 21:21

... exciting area of research forwards into the future. Indeed, obtaining accurate measurements of the concentrations, distributions and flux of all the main players involved in protein folding in the ... control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly. Mol Biol Cell 10, 2209–2219. 12 Kaloff CR & Haas IG (1995) Coordination of...

Ngày tải lên: 29/03/2014, 22:21