Báo cáo y học: " Identifying genetic networks underlying myometrial transition to labor" potx

... Guanylyl-Cyclase Signaling Stimulation of Adenylyl-Cyclase Signaling Cell Growth Glucocorticoid Synthesis and Metabolism Phospholipase A2 Inhibitor Activity Structural Constituent of Cytoskeleton Activation Synchronization ... that guide this transition are poorly understood. A difficult challenge in identifying the regulatory events that control the switch from myometrial quiescence t...

Ngày tải lên: 14/08/2014, 14:21

... mechanism for enzymatic hydrogen transfer. Biophys. J. 63, 689–699. 15. Kuznetsov, A.M. & Ulstrup, J. (1999) Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis. Can. J. ... effects are required to accommodate the kinetics of SLO, and may be equally important in many other hydrogen atom transfer reactions. Many H• transfer reactions are characterized by very lar...

Ngày tải lên: 31/03/2014, 23:20

... factor leukotriene B 4 (Fig. 3) [16,17]. This effect, attributable to EPA, is not seen with NSAIDs, which have no inhibitory effect on the 5-lipoxygenase pathway. Cytokines Other inflammatory ... mediators whose production is inhibited by fish oil are the cytokines tumour necrosis factor (TNF)-α and interleukin-1β, which are involved not only in production of inflammatory signs and symptoms...

Ngày tải lên: 09/08/2014, 07:20

... polyneuropathy and/or myopathy that can endure months to years after the acute illness [5]. Although the burden of these outcomes is increasingly appreciated, little progress has been made in identifying and ... stress hyperglycemia. In a systematic review, hyperglycemia or poor glycemic control was associated with ICUAW in five of six studies [6]. Two large randomized trials of intensive...

Ngày tải lên: 13/08/2014, 19:20

... Wong AK, Vyse TJ, Daly MJ, Altshuler D, Moser KL, Gaffney PM: Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 2008, 40:1059- 1061. 7. Musone SL, Taylor ... followed by well-powered genetic studies in both RA and SLE that will hopefully lead to the identification of the primary disease-related variants, some of which may arise from low-fr...

Ngày tải lên: 09/08/2014, 14:20

... is an autoinflammatory or an autoimmune disorder [3]. Dysfunction of the ubiquitin pathway has been implicated in cancer, neurodegenerative diseases and type 2 diabetes [4,5]. Carboxypeptidase ... characterized by oral and genital ulcera- tion and is complicated by eye, skin, joint and central nervous system lesions. It has long been understood that BD has a strong genetic component, but t...

Ngày tải lên: 09/08/2014, 14:22

... factor of interest Other transcription factors DNA methylase Methylated DNA Hybridize to microarray Hybridize to microarray Immunoprecipitate with antibody specific to a transcription factor Perform ... can be used to verify targets by PCR or dot blot, or the DNA may be sub-cloned and sequenced to identify new targets [44]. For ChIP array analysis, the purified DNA is amplified by P...

Ngày tải lên: 09/08/2014, 20:21

... sensitivity of 0.71 (95% CI: 0.66-0.76) and a specificity of 0.91 (95% CI: 0.88-0.93). These were not significantly different compared to the training set (sen- sitivity p = 0.27; specificity p = ... suggest that a binary rule for clas- sifying individuals as either above or below 500 copies/ ml is too simplistic. Rather it may need to be multiple markers as a set of complex binary partit...

Ngày tải lên: 10/08/2014, 05:21

... with dense networks, and therefore less likely to be implemented quickly. H owever, it is important to mention that social networks may function in count er- intuitive ways that may reduce the ... study aimed to examine the usefulness of methods to study in formation exchange networks in primary care practices, related to chronic heart failure, diabetes and chronic obstructive...

Ngày tải lên: 11/08/2014, 05:21

... specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway. J Virol 2004, 78:14043-14047. 47. Tan YX, Tan TH, Lee MJ, Tham PY, Gunalan ... TH, Lee MJ, Tham PY, Gunalan V, Druce J, Birch C, Cat- ton M, Fu NY, Yu VC, Tan YJ: Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its...

Ngày tải lên: 12/08/2014, 04:20