Báo cáo y học: "Histones: should I stay or should I go" pdf

... chromatin immunoprecipitation (ChIP) assays in combination with DNA microarrays that cover the entire yeast genome at a 1 kilobase (kb) resolution, they found that immunoprecipitating Myc-tagged histone H4 ... nucleosomes is dictated by the affin- ity of histone octamers for DNA, which is in turn highly regu- lated by the concerted action of ATP-dependent remodeling factors and histone-modify...

Ngày tải lên: 14/08/2014, 14:21

... variable clinical results were obtained with VC because of the difficulty of attaining clinically active doses. 6 VK 3 exhibited selective antitumor activity alone and in conjunction with many chemotherapeutic ... months and 11 continued for at least 1 year with one patient continuing for more than 2 years. Therapy was not discontinued in any patient due to vitamin toxicity or for...

Ngày tải lên: 08/08/2014, 17:20

... used both for therapy and to maintain remissions in SLE patients. This drug is known to inhibit IFN-α production by NIPCs/PDCs in vitro by the inhibition of endosomal acidification/maturation [23]. ... prominent immunoregulatory effects and might act as key cytokines, not only in the innate immune system but also in adaptive immune responses. Immunomodulatory effects by type I IFNs Type I...

Ngày tải lên: 09/08/2014, 01:21

... for citation purposes) biomechanics community and welcomes input and direc- tion from members. In September 2008, we had our first congress at Istituto Ortopedico Rizzoli, Bologna, Italy, chaired ... biomechanics of posterior tibial tendon dysfunction and flatfoot deform- ity), Professor George Arangio (Sailing charted seas: bio- mechanics and the orthopaedic surgeon), Dr. Mario Lafortune (Th...

Ngày tải lên: 10/08/2014, 21:23

... patients with cystic fibrosis have unexplained neu- rological issues, Chiari I malformation is likely. Rakheja et al. described two babies with a known diagnosis of Chiari I malformation and hydrocephalus; however, ... gait instability; hand wasting Chiari I with thoracic scoliosis and cervicothoracic syrinx Chiari decompression two months Resolution of symptoms Present report 10 months...

Ngày tải lên: 10/08/2014, 23:22

... School of Medicine, Division of Pulmonary and Critical Care, Atlanta, Georgia, USA 4 Director, Pulmonary Clinic, Grady Memorial Hospital and Assistant Professor of Medicine, Emory University School ... of Medicine, Division of Pulmonary and Critical Care, Atlanta, Georgia, USA Correspondence: Critical Care Editorial Office, editorial@ccforum.com Published online: 19 February 2003 Critical Car...

Ngày tải lên: 12/08/2014, 19:22

... a trans-conformation, with the nitrogen-bond hydrogen and the carbonylic oxygen oriented in opposite direc- tions) (Figure 3D). SAHA, consistent with its non-specific inhibitory activity on HDACs ... Federico Mele, Rome, Italy, and Ms. Dora Pinto, ibidem, for technical help, Ms. Maria Grazia Bedetti, ibidem, for admin- istrative support, and Dr. Mark Kanieff, ibidem, for the linguistic revis...

Ngày tải lên: 12/08/2014, 23:21

... mortality outcomes graphically, and more easily and rapidly than is possible using the quarterly standardized mortality ratios received from an ICU national audit programme, as already exists in ... in England. The goal is to minimize delays in recognizing significant deterioration in performance and to provide this expedited feedback locally to ‘management and clinicians [who] are well place...

Ngày tải lên: 12/08/2014, 23:23

... pul- monary complications characterized by T-lymphocyte alveolitis or lymphocytic interstitial pneumonia [7,8]. In Tax-expressing transgenic mice, inflammatory cells con- sisting mainly of lymphocytes ... addition to the HAM/TSP [2,3] and T-lymphocyte alveolitis or lymphocytic intersti- tial pneumonia [7,8]. The pathological association of HTLV -I with inflammatory multiorgan diseases in...

Ngày tải lên: 13/08/2014, 05:21

... pro- virus is mainly detected in CD4-positive lymphocytes, with about 10% in CD8-positive T-lymphocytes [48]. This situation possibly arises because Tax mainly induces the increase of CD4-positive ... T-lymphocytes in vivo by enhanced proliferation and suppressed apoptosis. In HTLV -I- infected individuals, no virions are detected in the serum. In addition, the infectivity of free virions is...

Ngày tải lên: 13/08/2014, 09:21