Báo cáo y học: "Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease" pps

... passage of information from the ER to the nucleus. The linear connectivity (activation of Ire1 → production of Hac1) of the two key players of the yeast UPR is supported by genetic analysis. Both ... substrate of Ire1; none of the approaches identifies any other mRNA as a qualified can- didate. Two of these approaches represent novel applications of cDNA...

Ngày tải lên: 14/08/2014, 14:21

... whether the spectral sensitivity of the circadian system also changes throughout the solar day. Reported here is a new study that was designed to determine whether the spectral sensitivity of the ... in the spectral sensitivity of circadian phototransduction mechanisms at two different times of the night. These findings are hypothesized to be the result of a change i...

Ngày tải lên: 10/08/2014, 09:20

... permission. The epidemiology of systemic lupus erythematosus A population-based study examined the incidence and mortality of systemic lupus erythematosus (SLE) in a geographically defined population ... of the general population of the same age and sex. Over 25 years of follow up of a cohort of 57 adults with a history of RA [46], the mortality rate among JRA cases...

Ngày tải lên: 09/08/2014, 14:20

... and allows the estimation of DSM-IV diagnoses for major dis- orders [21]. The translation of the M-CIDI into Finnish was made pair wise by psychiatric professionals and revised by others. The official ... for FDFT1 rs11549147. All samples were successfully genotyped, yielding the suc- cess rate of 100% for all SNPs, and about 5% of samples were re-genotyped to confirm...

Ngày tải lên: 10/08/2014, 09:20

... for school six in the second year of the trial. In the third year, school six had only two first-grade classrooms and they were taught by the initially assigned WD and SC teachers. In spite of ... at the level of the child and the social contexts of family, classroom and school, peers, and com- munity. In line with the results from our previous trials, we hypothesize...

Ngày tải lên: 11/08/2014, 05:21

... cytom- etry. The BALF recovery and the viability of cells did not differ significantly between the patient groups. Cellular profiles are shown in Table 2. Flow cytometry BALF cells were analyzed by four-colour ... effectiveness of corticos- teroid therapy. Given the assumption that MCP-1 and CCR2 are important players in the pathophysiology of ILD in children, the lack of...

Ngày tải lên: 12/08/2014, 18:22

... rate of adequacy. Monotherapy with imipenem/cilastin is suitable for EA only in absence of this risk factor for MDR. For other patients, only antibiotic combinations may achieve high adequacy rates. Introduction Postoperative ... the choice of empirical antibiotic therapy (EA) raised by these MDR microorganisms. Based on these concerns, the aim of this study was first to ide...

Ngày tải lên: 13/08/2014, 20:21

... phosphorylation activity of the CK2 a subunit [39]. The functional homology of the Stellate protein with the CK2 b subunit rises the f ormal possibility t hat the Stellate protein may take part in the ... replacement of one b subunit by another i n the case of a deficiency of any of the subunits, i.e. a so called ÔbypassÕ mechanism may operate in order to maintain...

Ngày tải lên: 21/02/2014, 15:20

... pathways are necessary for the catalytic activity, but different residues may be involved. In an important step for the understanding of the essentials for cytochrome c oxidase activity and coupled ... correlate with the oxidized and the negative signals with the reduced form of the enzyme. For the reduced form, the Soret band can be observed at 415 and 442 nm, a...

Ngày tải lên: 21/02/2014, 15:20

... with PsA (but their results were not analyzed separately). They confirmed that MRI sacroiliitis was very common in SpA, most often involving the dorsocaudal part of the joint in early disease in ... used manual outlining of synovial membrane to quantify synovitis in their study of 84 patients with inflammatory arthritis, 18 of whom had reactive arthritis or PsA. MRI of the wri...

Ngày tải lên: 09/08/2014, 07:20