Báo cáo y học: "Translational regulation of gene expression" docx

... is the regulation of translation of maternally inherited mRNA by cytoplasmic polyadenylation in Xenopus oocytes. Polyadenylation is required before the mRNA can be trans- lated, and regulation of ... a property previously described only for cellular mRNAs. RNA-binding proteins have key roles in the regulation of nearly every aspect of gene expression. They often display a m...

Ngày tải lên: 14/08/2014, 14:21

... protein Systemic inflammatory biology was assessed by circulating levels of CRP. Blood spot samples obtained during study years 2, 3, and 4 were analyzed using a high-sensitivity enzyme immunoassay ... expression of inflammatory and immune response genes. Bioinformatic analysis of differentially expressed promoters suggests that these effects may be shaped by reduced activity of the a...

Ngày tải lên: 14/08/2014, 08:20

... microarray system used was an Affymetrix U95A GeneChip (Affymetrix, Santa Clara, CA); 4566 genes were analyzed. Four healthy donors of PBMC were studied. † The microarray system used was an Affymetrix ... signatures in sys- temic lupus erythematosus blood. J Exp Med 2003, 197:711- 723. 6. Han GM, Chen SL, Shen N, Ye S, Bao CD, Gu YY: Analysis of gene expression profiles in human system...

Ngày tải lên: 09/08/2014, 01:23

... study analysing IRF5 expression in blood cells from SLE patients did not find any signifi- cant effect of this SNP or of any of the functional polymorphisms [26]. These contrasting pieces of evidence do ... reproducibility and generality of the results. Also, it afforded us the opportu- nity to test the independent contribution of each functional polymorphism and to identify the S...

Ngày tải lên: 12/08/2014, 15:23

... to evoke airway hyperreactivity in animal studies [12-14], they may have distinct roles in allergen-dependent airway obstruction [24]. Hence, NGF may play a role in the early airway response (EAR) ... may be differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a potential role in airway inflammation. Background Allergic asthma is characterised by ......

Ngày tải lên: 12/08/2014, 16:20

... The advantage of using the BAC as a cloning vector is that it can carry as much as 200 kb of genomic DNA - typically enough to include most, if not all, of the appropriate regulatory elements of the gene. ... al. [22] combined microarray analysis with electrophysiology and neurotransmitter immunocyto- chemistry to describe the variability within and between 12 known classes of fore...

Ngày tải lên: 14/08/2014, 07:21

... brain autopsy and biopsy samples found significant change in one of the genes, indicating that a substantial proportion of all expressed genes could be affected by death [10]. We surveyed gene expression ... SJ, Choudary PV, Li J, Over- man KM, Atz ME, Myers RM, Jones EG, et al.: Effect of agonal and postmortem factors on gene expression profile: quality con- trol in microarray anal...

Ngày tải lên: 14/08/2014, 16:20

... KH: Yesterday's polyploids and the mystery of diploidization. Nat Rev Genet 2001, 2:333-341. 5. Blanc G, Wolfe KH: Functional divergence of duplicated genes formed by polyploidy during Arabidopsis ... Because of the high sequence similarity of recently duplicated genes and the risk of artificially increased correlation due to cross- hybridization, we selected expression data on...

Ngày tải lên: 14/08/2014, 16:21

... in inflammatory arthritis. J Clin Invest 2000, 105:1799-1806. Arthritis Research Vol 4 No 3 Vincenti and Brinckerhoff to the transcription of an array of inflammatory genes, their direct regulation of MMP ... Brinck- erhoff CE: A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflamma- tory cytokines. Arthritis Rheum 2001, 44:1096-...

Ngày tải lên: 09/08/2014, 03:24

... occupancy of RNA polymerase II (PolII), Bing Ren (University of California, San Diego, USA) presented data from a large ChIP-chip study of five types of mouse tissue. He showed that PolII is largely ... application of ChIP-PET to studying genome occupancy of key transcription factors in embryonic stem (ES) cells was the subject of a presentation by Huck-Hui Ng (Genome Institute...

Ngày tải lên: 14/08/2014, 16:21