Báo cáo y học: "Why genomics is more than genomes" pot

... in other systems. Yet Tina Henkin (Ohio State University, Columbus, USA) has recently proposed that many Gram-positive bacteria regulate genes for amino-acid biosynthesis and tRNA synthetases ... nearly 200 at the time of writing and they offer a powerful route to understanding aspects of a microorganism’s biology. Yet, as shown at the 2004 meeting, there are always new aspects of biology ......

Ngày tải lên: 14/08/2014, 14:21

... support the validity of the hydrophobicity hypothesis [5,16-26,28,29]. The flaws of each hypothesis On the surface, the hydrophobicity hypothesis does not appear to adequately explain the retention ... Genome Biology 2005, Volume 6, Issue 5, Article 110 Daley and Whelan 110.3 Genome Biology 2005, 6:110 Box 1 An explanation of terms The hydrophobicity hypothesis. This hypothesis ini- tially...

Ngày tải lên: 14/08/2014, 14:21

... protein domains is a well-established research area, the study of repeat domains is still in its infancy. Indeed, RepeatGluer [17] is the only existing algo- rithm for repeat domain analysis. While ... a repeat library typically contains several hundred to several thousand sequences, and the annotation of repeats is typically incomplete, the analysis of a repeat domain graph is a no...

Ngày tải lên: 14/08/2014, 16:20

... quality program for asthma diag- nosis is nowadays shared, but was more lax 15 years ago than today, which introduces a possible bias since many of the NA cases were early diagnosed. Yet, there ... needing ther- apy for the rest of their lives, but asthma remission also does exist (12). The more severe the asthma is in childhood the more likely it is that the disease will...

Ngày tải lên: 26/10/2012, 09:48

... (Affymetrix). DNA microarray analysis Data analyses were performed using the GeneChip Expression Analysis Software (version 3.2, Affymetrix). First, single array analysis was performed [11] to ... concentrations of ethanol. Gene expression profiling using microarray technology allows the expression analysis of thousands of genes simultaneously [6-8]. This method is more informati...

Ngày tải lên: 31/10/2012, 15:28

... patterns yielded, in polyacrylamide gel at pH 8.6, by the new a s1 -Cas phenotype, subsequently shown to be a heterozygous M/F (M being the new variant), in comparison with two reference phenotypes ... [18]. Enzymatic hydrolyses Trypsin (Boehringer Mannheim) hydrolysis was carried out in 0.4% NH 4 HCO 3 ,pH8.5,at37°C, for 4 h, in a substrate/enzyme ratio of 5 0 : 1 (w/w). Dephosphorylation wi...

Ngày tải lên: 22/02/2014, 04:20

... mitochondria is mediated by the cytoplasmic HSP70. ACKNOWLEDGEMENTS We thank Dr. K. Nagata (Kyoto University) for his helpful comments on the manuscript. We thank Dr. D. J. Naylor (The University of Adelaide, ... proinflammatory cytokine, tumour necrosis factor a, and with various psychosocial measures [15]. In the mammalian cytoplasm, HSP60 may play important roles including chaperone activ...

Ngày tải lên: 08/03/2014, 09:20

... peptide with four disulfide bridges (2256.74 MH + ), with only a 0.8-Da difference. Computer analysis indicated that this peptide is a new member of the hepcidin family, bass hepcidin (SwissProt number ... that was analyzed in these same fish and found not to be induced in any tissue [8]. DISCUSSION We report here the discovery of a novel AMP, bass hepcidin, isolated from the gills of hybrid...

Ngày tải lên: 24/03/2014, 03:21

... Myr 2 GroPGro, dimyristoylglycerophosphoglycerol; Nbd-Myr 2 GroP Etn, [N-(7-nitro- 2-1,3-benzoxadiazol-4-yl)-dimyristoylglycerophosphoethanolamine; rhodamine-GroP Etn, N-(lissamine rhodamine B sulfonyl)- diacylglycerophosphoethanolamine; ... family display a high degree of sequence similarity although they are secreted by a variety of different moulds [9–11], i.e. restrictocin and mitogillin,...

Ngày tải lên: 31/03/2014, 23:20

... antidepressants more likely [15-17,28-31]. Understanding the underlying biological and personality factors profoundly shapes and reorganises how we view psychiatric disorders today and how they will be ... polymorphis ms only mildly contrib ute to such ph enotypical alterations, they may be taken into account when selecting a pharmacological agent. A scale closely related to a given polymor...

Ngày tải lên: 08/08/2014, 23:21