Báo cáo y học: "Current address: Centro Nacional de Biotecnología (CNB), Campus de la Universidad Autónoma" pptx

... ‡ Current address: Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK. § Current address: Centro Nacional de Biotecnología (CNB), Campus de la Universidad ... were derived by our cloning protocol using cDNA from 10 lymphoblastoid cell lines as a template, as polymor- phism would be easier to identify where each cDNA mix could only...

Ngày tải lên: 14/08/2014, 14:21

... mark classic transcriptional regulatory sequences, and what the relationship is between regulatory potential and degree of evolutionary constraint. The available literature is derived largely from ... extended phylogenetic depth in predicting CNCS regulatory activity. Second, we aimed to assay regulatory potential in human cells. The latter was motivated by the fact that in the majority of .....

Ngày tải lên: 14/08/2014, 21:20

... resistance. Although methods of early detection were always desirable, not much effort has been made in past decades to support research in this field. Only recently has interest increased in improv- ing ... laboratory techniques for fresh cancer cell cultures are now available [7, 8]. The cell preparation may vary de- pending on the tumor type in test. Table 1 shows frequently tested...

Ngày tải lên: 25/10/2012, 11:10

... progressively deteri- orates, they often develop behavioral symptoms that can be very troublesome to the caregiver and/or family. Com- mon psychiatric and behavioral symptoms frequently seen include apathy, ... approximately 15% of all de- mentias [2], while some patients may also display dementia of mixed etiology (AD/VaD). A collaborative study of the incidence of dementia and major subty...

Ngày tải lên: 08/08/2014, 20:23

... polyester-based biodegradable polymers strongly suggests the feasibility of their application in cartilage repair. Interestingly, the co- polymer, polyD,L-lactide-co-glycolide (PLGA), was recently shown ... PLA scaffold, our labo- ratory has recently constructed a single-unit osteochon- dral plug consisting of a collagen type II-positive, but colla- gen type I-negative, hyaline cartilage-like...

Ngày tải lên: 09/08/2014, 01:23

... relief may be relatively short in OA, with effects lasting only a few weeks [40], although longer responses may occur in RA. Concerns over effects on cartilage have been partly allayed by studies suggesting ... no long-term deleterious events from such therapy [41]. Intra-articular hyaluronic acid (hyluronan) is a high-molecular- mass polysaccharide with a multiplicity of biological actions A...

Ngày tải lên: 09/08/2014, 10:20

... previously unmethylated DNA. The pattern of DNA methylation is then maintained during cell division by the enzyme DNMT1 [77]. Global hypomethylation in T cell DNA has been described in lupus [78]. Indeed, ... stratification by clinical and laboratory criteria. Two high-throughput platforms for SNP typing have been developed in recent years: AffyMetrix GeneChip ® Mapping Arrays (AffyMetrix, In...

Ngày tải lên: 09/08/2014, 10:20

... were divided in two groups. Group I received surgery followed by adjuvant, mainly platin doublets and anthracycline based, modern chemo- therapy protocols. Group II had definitive surgery follow- ing ... if hilar or mediastinal lymph node involvement is present. Surgery in multimodality treatment with chemotherapy and chemoradiotherapy Platinum and etoposside based regimens of chemother- apy...

Ngày tải lên: 10/08/2014, 10:20

... heterochromatin protein-1 to modu- late the activity of lysine-specific demethylase (LSD) 1 [34], a histone demethylase for H3K4 and H3K9 that is also important for global DNA methylation [35]. How- ever, ... 5-hydroxymethylcytosine (5-hmC) [20], which to be an intermediate in DNA demethylation. Bone marrow samples from patients with TET2 muta- tions displayed uniformly low levels of 5-hmC in...

Ngày tải lên: 10/08/2014, 21:23

... of secretion of cytokines. The Th1 cytokine interferons inhibit chlamydial replication in vitro by inducing the degradation of tryptophan, resulting in a state of chlamy- dial latency, with developmental ... of chlamydial pneumonias. [6] Cellular immune response to chlamydial antigens of the Th1 type is important. [7,8] Chlamydial infections induce inflammatory changes that might induce modul...

Ngày tải lên: 11/08/2014, 10:23