Báo cáo y học: "Alternative splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specific" pot

... splicing of mouse transcription factors affects their DNA-binding domain architecture and is tissue specific Bahar Taneri * , Ben Snyder * , Alexey Novoradovsky * and Terry Gaasterland *† Addresses: ... DNA-binding domains of these proteins. Our analyses revealed that within a single tissue there gener- ally is only one TF isoform, and that across tissue...

Ngày tải lên: 14/08/2014, 14:21

... similarity of the regulatory and physiological outcomes of knocking down MYB and MLLT3, we assumed that these two factors might function synergistically. To explore this possible synergistic effect, ... and their target genes. In this paper we analyze the regulatory relationships between 78 myeloid transcription factors and their coding genes by using the matrix RNAi sys...

Ngày tải lên: 09/08/2014, 20:20

... response. Conclusions Generation of different splice variants of ASC potentially provides a mechanism to regulate assembly and activity of inflammasomes and thereby release of IL-1β and IL-18 during the inflammatory host ... response. Expression of different ratios of activating and inhibitory isoforms of ASC might promote inflammation at early stages of infections an...

Ngày tải lên: 11/08/2014, 03:20

... individuals and patients with rheumatoid arthritis (RA) and other rheumatic diseases such as SLE, Sjögren’s syndrome (SS), systemic sclerosis (SSc), and polymyositis/dermatomyositis (PM/DM). ... the risk of developing RA, its pathogenesis is not completely understood[11, 12]. MCs have been implicated in RA and experimental models of this autoimmune disorder. Tissue specime...

Ngày tải lên: 12/08/2014, 18:20

... replication of mouse mammary tumor virus. Background It is generally accepted that environmental factors play a role in the etiology of various types of cancer. This is most clearly demonstrated by epidemiological ... study does not prove causality, it certainly lends more weight to the hypothesis linking MMTV and human dis- ease and might further substantiate the notion tha...

Ngày tải lên: 13/08/2014, 05:22

... regulation of Ministry of Health and was announced nation-wide via official newspaper of the state [11]. This is a quasi-experimental study performed in four year period, which included two years ... Statistical Analysis: Rates in every 6 months periods of the study period were analyzed by com- parison of proportions with the chi-square test. Cor- relations between antibio...

Ngày tải lên: 25/10/2012, 11:00

... This catalytic property is shared by only the minority of 4CL isoforms studied to date from any plant. As the cDNA encoding 4CL1 was apparently missing from the pool of partial cDNA clones isolated ... survey of 4CL isoenzymes from soybean by: (a) completing the existing cDNAs [20]; and (b) by isolating l acking members of the g ene family. Moreover, we aimed to disclose details...

Ngày tải lên: 22/02/2014, 04:20

... activation, most of this AA is replaced by other fatty acids. Finally, because cell activation is accompanied by an increase in PAF biosynthesis via acetylation of 1-alkyl-2-lyso-GPC by acetyl transferase (Fig. ... ATP- independent fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent transacylation activity toward lysopho- sphatidic acid catalyzed by acyl-coenzyme A...

Ngày tải lên: 22/02/2014, 07:20

... excre- tion [16]. The aim of this study was to explore the molecular mechanism of ligand binding and activation of PXR by modeling and site-directed mutation of the PXR ligand binding domain (LBD). In ... inter- actions. PXR is coexpressed in tissues where CYP3A is induced and expressed [5]. The key role of PXRs in CYP3A induction has been further corroborated by targete...

Ngày tải lên: 08/03/2014, 16:20