Báo cáo y học: "Variation in alternative splicing across human tissues" potx

... Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol Cell 2000, 5:949-957. 61. Chan RC, Black DL: The polypyrimidine tract ... cis- regulatory elements and trans-acting factors involved in tis- sue-specific AS. Results and discussion Variation in the levels of alternative splicing in different human...

Ngày tải lên: 14/08/2014, 14:21

... experimentally induced intron reten- tion in a number of genes containing introns. Yeakley et al. [22] detected alternative splicing in six human genes using a fiber-optic microarray platform. ... mRNA processing in yeast using splicing- specific microarrays. Science 2002, 296:907-910. 22. Yeakley JM, Fan JB, Doucet D, Luo L, Wickham E, Ye Z, Chee MS, Fu XD: Profiling alternativ...

Ngày tải lên: 09/08/2014, 20:20

... Strain differences in the pattern and intensity of wheel running activity in laboratory rats. Experientia 1991, 47:593-598. 23. Siebert U, Wollnik F: Wheel-running activity rhythms in two inbred ... Variation in circadian rhythms and nocturnality may, hypothetically, be related to or independent of genetic variation in photoperiodic mediation of seasonal changes in physiology and...

Ngày tải lên: 10/08/2014, 09:20

... concentrations during the first 10 days of intensive care unit (ICU) stay. There was an average decrease of 16g/l in haemoglobin concentrations in all patients admitted to the ICU over the 10-day monitoring interval. Institution ... determine the degree of interinstitutional transfusion practice variation and reasons why red cells are administered in critically ill patients. Study desig...

Ngày tải lên: 12/08/2014, 18:20

... iden- tifying SNPs. Genotyping The genotyping methods used in this study are described in Additional File Table 2. In addition to four SNPs in or flanking conserved sequences, we genotyped six ... (CNE-C) in the IL4 gene, may influence susceptibility in combination with other variation in IL4, or may merely be in LD with other variation in the gene that influences susceptibi...

Ngày tải lên: 12/08/2014, 18:20

... be explained in several ways. First, the interventions do not affect outcome. Certainly, there is mounting evidence that some of the studied interventions, such as application of the pulmonary artery ... outcome. Second, any beneficial effects are offset by unwanted side effects. For example, better titration of care secondary to information gained by pulmonary artery catheter use may be of...

Ngày tải lên: 12/08/2014, 19:22

... Discovery of 4-ben- zoyl-1-[(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3- yl)oxoacetyl]-2-(R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. ... binding site, or both. Certainly brain-derived envelopes are more likely to carry the N283 in the C2 CD4 binding site as reported by Dunfee et al. [35] and confirmed by our group Sensitivity...

Ngày tải lên: 13/08/2014, 06:20

... to shunt. Indeed, Riley and Cournand [20] recog- nized in the 1950s that oxygenation problems should be divided in this way. With the ability to identify two-parameter models rapidly using pulse ... oximetry data [14] and simple clin- ical methods [13], their clinical application seems timely. Table 1 Numbers of patients changing disease group with increasing inspired oxygen fraction (FiO...

Ngày tải lên: 13/08/2014, 08:21

... A2 y F4 Cystathionine beta synthase Cystathionine-beta-synthase z K11 Cold inducible RNA binding Cold inducible RNA-binding protein; (CIRBP) glycine-rich RNA binding protein; aa F2 Hepatocyte ... popula- Inconsistent - other metabolism qq C7 Transketolase Transketolase rr H8 Fatty acid binding 7 brain Fatty acid binding protein 7 brain (B-FABP) ss A3 Fatty acid binding H6 Fatty acid binding...

Ngày tải lên: 14/08/2014, 14:21

... research interactions information Genome Biology 2006, 7:R65 amino acid indels (intron phase 0: alanine, valine; phase 1: arginine, glycine, serine; phase 2: arginine, glutamine, leu- cine) and ... splicing noise. Con- sistently, such subtle changes by alternative splicing may result in functional differences for the two proteins. An arginine insertion between two zinc fingers results...

Ngày tải lên: 14/08/2014, 17:22