Báo cáo sinh học: "Genomic evaluations with many more genotypes" docx

... quickly become more reliable over the last two years in many countries as more animal s have been genotyped for 50,000 markers. Evaluations can also include animals genotyped with more or fewer ... most missing alleles for progeny genotyped with lower marker density. Accurate imputation can give breeders more reliable genomic evaluations on more animals without genotyping...

Ngày tải lên: 14/08/2014, 13:21

... HRP, transduced LLC cells we re treated with IAA at indicated concentrations in Figure 2D. The results were s hown as the percentage of cell viability with respect to control cells without IAA treatment. LLC ... treat- ment (group III) was associated with more potent antitu- mor effects (groups III vs II, p > 0.05; groups III vs I, p = 0.047 on day 9 to 24). Combination treatment...

Ngày tải lên: 18/06/2014, 19:20

... inhibition of oncogenic BRAF V600E with vemurafenib, together with the stimula- tion of AMPK with metformin, m ay co-operate to induce cell death in cells with this oncogenic driver mutation. ... cell lines with antagonistic effects of vemurafe- nib combined with metformin. As with the BRAF V600E mutant cell lines, effects on pACC followed the effects of single agent metformin...

Ngày tải lên: 18/06/2014, 19:20

... or a reporter gene within the cells. Moreover, overexpression of endophilin or its fragments had no or little effect on the production of HIV virus-like particles, correlating with our observation that ... that more than one domain can direct incorpora- tion. The endophilin fragments may have been targeted to virions by dimerization with endogenous endophilin, or by indirect interaction...

Ngày tải lên: 06/08/2014, 18:20

... w T (v). Lemma 7. Let G be a graph with a trunk M of order more than one, and let m be a vertex with maximum total distance in G. Then if m ∈ M, there exists a graph F with V (F ) = V (G) and a vertex ... of order more than one, and let m be a vertex with maximum total distance in G. Then if m ∈ M, there exists a graph F with V (F ) = V (G) and a vertex x ∈ M, such that D(F ) ≥...

Ngày tải lên: 07/08/2014, 15:23

... chromosome of 1 M. To compare these results with a more realistic situation, we simulated the scenario for closely related breeds with a genome of 10 chromosomes with a total genome size of 10 M, 60,000 ... animals with training in an ABxCD cross was similar in accuracy to that for pure- bred B animals with training in an ABxC cross (Tables 2 and 3). It is interesting that the acc...

Ngày tải lên: 14/08/2014, 13:21

... and some QTL are in LD with many markers (requires more smoothing) whereas others only with few markers (requires less smoothing). It can be assumed that ULM might cope with unequal marker densities ... number of SNP in LD with the QTL is higher in high marker density situations. Additionally, with increasing number of SNP, more SNP show by chance spurious effects, and hence,...

Ngày tải lên: 14/08/2014, 13:21

... maternal allele is expressed at this QTL. Moreo- ver, a QTL for neck weight without external fat was identi- fied, which was not detected in the analysis without imprinting modelling. At this QTL, ... Christian-Albrechts-University of Kiel, Hermann-Rodewald-Strasse 6, D-24118 Kiel, Germany and 4 PIC Germany, Ratsteich 31, D-24837 Schleswig, Germany Email: Carol-Anne Duthie - Carol-Anne.Duth...

Ngày tải lên: 14/08/2014, 13:21

... tran- sition from a high to a lower health status to be associated with a decrease in heritability, and this change tended to be more associated with a decrease in the genetic variance than an increase ... environmental pathogens present within the lower health status environ- ment. Ideally, markers for increased resistance to infectious dis- ease should correlate (within a herd) with...

Ngày tải lên: 14/08/2014, 13:21

... markers in each McMC iteration has been sug- gested [4,7]. However, with a large number of SNP mar- kers and many animals without genotypes such a solution seems computationally unfeasible in ... the situation with non-genotyped animals. The model specifies that a breeding value is the sum of a genomic and a polygenic genetic random effect, where genomic gene tic random effects are corr...

Ngày tải lên: 14/08/2014, 13:21