a textbook of modern toxicology phần 9 pdf
a textbook of modern toxicology phần 9 pdf
... substance on a test organism
as compared with the effect of a standard preparation of a basic toxicant. Although
bioassay has many drawbacks, particularly lack of specificity, it can provide a rapid
analysis ... very stagnant conditions are encoun-
tered in the water or air. Modeling the transport of a chemical in air is particularly
difficult because of the high spatial and...
a textbook of modern toxicology phần 6 pdf
... signaling hormones along the cascade (i.e., hypothalamic–pituitary–gonadal
axis), and sometimes, a terminal target organ of the signaling pathway (i.e., hypotha-
lamic–pituitary–gonadal–hepatic axis).
Endocrine ... such as gamma-glutamyl
transpeptidase, alkaline phosphatase, and aromatic acid decarboxylase are more preva-
lent in cerebral microvessels than in nonneuronal capillaries. Most...
a textbook of modern toxicology phần 1 docx
... AAAAAAAA 3'
AG UUU GU AG UAA AAUAA AAAAAAA
AG TTT TAA AATAAGT AG
Figure 2.2 Transcription, mRNA processing, and translation. DNA sense strand is designated
by bold lines, hnRNA and mRNA by thinner ... codon
polyadenylation signal
translation termination codon
TRANSCRIPTION
PROCESSING
TRANSLATION
Amino terminusProtein
mRNA
hnRNA
Met Phe Stop Carboxy terminus
ATG GT
AUG GU
AUG UUU UAA A...
a textbook of modern toxicology phần 2 docx
... clams, and other bivalves of the cold
and warm temperate areas of the Atlantic and Pacific Oceans, mainly in Japan
and Europe. Only two cases of DSP have been documented in North America.
Ciguatera ... associated with cardiovascular effects. Concentrations of 100 ppm can
cause headaches, dizziness, nausea, and breathing difficulties. An acute concentration
of 1000 ppm is invariably fa...
a textbook of modern toxicology phần 3 ppt
... by a peroxidase that uses prostaglandin G as a substrate. In at least some of these
cases, the identity of this peroxidase has been established as a prostaglandin synthase.
Many of the reactions ... depots. The
antimalaria drug quinacrine accumulates due to reversible intracellular binding, and
the concentration in the liver can be several thousand times that of plasma. Another...
a textbook of modern toxicology phần 4 pps
... Examination of
the term placentas of smoking human mothers revealed a marked stimulation of aryl
hydrocarbon hydroxylase and related activities—remarkable in an organ that, in the
uninduced state, ... desaturated fatty acids are highly susceptible to free radical attack, neighboring
fatty acids are readily affected, and the initial metabolic transformation results in a cas-
cade of...
a textbook of modern toxicology phần 5 ppt
... MUTAGENICITY
Mutagens are chemical and physical agents that are capable of producing a mutation.
Mutagens include agents such as radiation, chemotherapeutic agents, and many car-
cinogens. A mutation ... cell/hypoxanthine-guanine
phosphoribosyl transferase assay, the mouse lymphoma a ssay, the mammalian trans-
formation assay, sister chromatid exchange, and the chromosome aberration a...
a textbook of modern toxicology phần 7 pptx
... 2, and 3 days. Grading is subjective and based on the appearance of the cornea,
particularly as regards opacity; the iris, as regards both appearance and reaction to
light; the conjunctiva, as ... exposures. IgE acts as a mediator of allergy and par-
asitic immunity. IgA is found in secretions such as mucous, tears, saliva, and milk,
as well as serum, and acts locally to block entrance...
a textbook of modern toxicology phần 8 doc
... probably unattainable
with birds or wild mammals, even through bobwhite quail and mallards are easily reared
in captivity. The genetics of the birds and mammals used are much more variable than
are ... environmental contaminant is applied to the leaves of the terrestrial plant sorghum
(Sorgum halpense), and then salt marsh caterpillars (Estigmene acrea) are placed on
the plants. The larva...
a textbook of modern toxicology phần 10 doc
... mating
and migration habits) are considered.
Finally, many extrapolation methods are limited by the availability of suitable
databases. Although these databases are generally largest for chemical stressors ... human and animal use, and requires
proof of both safety and efficacy. This act contains the Delaney Amendment, which
states that food additives that cause cancer in humans or animals...
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