a textbook of modern toxicology phần 6 pdf

... proce- dures (SOPs), quality assurance/quality control manuals (QA/QC manuals), procedural manuals, analytical method files, and laboratory information management systems A Textbook of Modern Toxicology, ... procedures are used to maintain a measurement system (i.e., a gas chromatograph) in a statistically satisfactory state to ensure the production of accurate and reliable da...

Ngày tải lên: 16/03/2014, 11:43

... extrapolation of data from low values of R and the assumption that statistical distributions of data are the same at high R as they are at low R are questionable. Material quality is another parameter ... sets are often necessary, the data in Figure 2. 16 illustrate that single parameters with which to consolidate data sets are not always viable because the individual groupings of...

Ngày tải lên: 03/07/2014, 20:20

...

Ngày tải lên: 22/07/2014, 04:21

... Point Estimation and its variance attains the Cramér–Rao bound. 12.4.2 Refer to Exercise 12.3.5 and investigate whether the Cramér–Rao bound is attained. 12.4.3 Refer to Exercise 12.3 .6 and investigate ... () ∈ [] = () ∈ [] By assuming the existence of an MLE, we have that the maximum at the left-hand side above is attained at an MLE ˆ θθ θθ θ. Then, clearly, the right-hand side attains i...

Ngày tải lên: 23/07/2014, 16:21

... periods of time, feasting them royally, then sending them back home after extracting gifts of information and knowledge. Whether this is a conscious use of the marebito Handbook of Japanese Mythology 214 ... to the land of the kamui bearing the usual gifts of wine and inau, and told her kinfolk of human generosity. The humans feasted on her discarded mundane form. Handbo...

Ngày tải lên: 05/08/2014, 14:21

... AUG GU AUG UUU UAA AAUAA AAAAAAAA 3' AG UUU GU AG UAA AAUAA AAAAAAA AG TTT TAA AATAAGT AG Figure 2.2 Transcription, mRNA processing, and translation. DNA sense strand is designated by bold ... 2,3,7,8-terachloro-dibenzodioxane (TCCD) Induction of CYP 1A1 and 1B1 H 114 E Rat hepatoma Hepatocyte Polychlorinated biphenyls (PCBs) Induction o f CYP 1A1 HepG2 Human hepatoblastoma Hepatocyt...

Ngày tải lên: 14/08/2014, 11:21

... clams, and other bivalves of the cold and warm temperate areas of the Atlantic and Pacific Oceans, mainly in Japan and Europe. Only two cases of DSP have been documented in North America. Ciguatera ... the hands and arms, perforation of the nasal septum (probably caused by chromic acid), inflammation of the larynx and liver, and bronchitis. Chromate is a carcinogen causing bronchoge...

Ngày tải lên: 14/08/2014, 11:21

... by a peroxidase that uses prostaglandin G as a substrate. In at least some of these cases, the identity of this peroxidase has been established as a prostaglandin synthase. Many of the reactions ... depots. The antimalaria drug quinacrine accumulates due to reversible intracellular binding, and the concentration in the liver can be several thousand times that of plasma. Another...

Ngày tải lên: 14/08/2014, 11:21

... Examination of the term placentas of smoking human mothers revealed a marked stimulation of aryl hydrocarbon hydroxylase and related activities—remarkable in an organ that, in the uninduced state, ... desaturated fatty acids are highly susceptible to free radical attack, neighboring fatty acids are readily affected, and the initial metabolic transformation results in a cas- cade of...

Ngày tải lên: 14/08/2014, 11:21

... MUTAGENICITY Mutagens are chemical and physical agents that are capable of producing a mutation. Mutagens include agents such as radiation, chemotherapeutic agents, and many car- cinogens. A mutation ... cell/hypoxanthine-guanine phosphoribosyl transferase assay, the mouse lymphoma a ssay, the mammalian trans- formation assay, sister chromatid exchange, and the chromosome aberration a...

Ngày tải lên: 14/08/2014, 11:21

... signaling hormones along the cascade (i.e., hypothalamic–pituitary–gonadal axis), and sometimes, a terminal target organ of the signaling pathway (i.e., hypotha- lamic–pituitary–gonadal–hepatic axis). Endocrine ... such as gamma-glutamyl transpeptidase, alkaline phosphatase, and aromatic acid decarboxylase are more preva- lent in cerebral microvessels than in nonneuronal capillaries. Most...

Ngày tải lên: 14/08/2014, 11:21

... 2, and 3 days. Grading is subjective and based on the appearance of the cornea, particularly as regards opacity; the iris, as regards both appearance and reaction to light; the conjunctiva, as ... exposures. IgE acts as a mediator of allergy and par- asitic immunity. IgA is found in secretions such as mucous, tears, saliva, and milk, as well as serum, and acts locally to block entrance...

Ngày tải lên: 14/08/2014, 11:21

... probably unattainable with birds or wild mammals, even through bobwhite quail and mallards are easily reared in captivity. The genetics of the birds and mammals used are much more variable than are ... environmental contaminant is applied to the leaves of the terrestrial plant sorghum (Sorgum halpense), and then salt marsh caterpillars (Estigmene acrea) are placed on the plants. The larva...

Ngày tải lên: 14/08/2014, 11:21

... substance on a test organism as compared with the effect of a standard preparation of a basic toxicant. Although bioassay has many drawbacks, particularly lack of specificity, it can provide a rapid analysis ... very stagnant conditions are encoun- tered in the water or air. Modeling the transport of a chemical in air is particularly difficult because of the high spatial and...

Ngày tải lên: 14/08/2014, 11:21

... mating and migration habits) are considered. Finally, many extrapolation methods are limited by the availability of suitable databases. Although these databases are generally largest for chemical stressors ... human and animal use, and requires proof of both safety and efficacy. This act contains the Delaney Amendment, which states that food additives that cause cancer in humans or animals...

Ngày tải lên: 14/08/2014, 11:21