Essentials of Clinical Research - part 3 ppt

... July 2005; 11(4) :35 3 35 9. 52. Institute of Medicine of the National Academies. The Future of Drug Safety. http://www.nap. edu/books/ 030 31 030 45/html/1.html. Accessed April 3, 2007. 53. Public Health ... use Short-term use of drug Narrowly-specified or restricted population PE-POSTMARKETING Large population of users Long study period Off-label use; new indications Long- term...

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... Med. Dec 30 , 19 93; 12(24): 233 3– 234 1. 55. Donnan PT, Wang J. The case-crossover and case-time-control designs in pharmacoepidemi- ology. Pharmacoepidemiol Drug Saf. May 2001; 10 (3) :259–262. 56. ... McMahon AD, Davey PG, et al. Association of road-traffic accidents with benzo- diazepine use. Lancet. Oct 24, 1998; 35 2(9 137 ): 133 1– 133 6. 57. Handoko KB, Zwart-van Rijkom JE, Herm...

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... 209–217, 2 23, 225–227, 229, 230 , 232 , 234 –240, 242, 250, 269–271, 2 73, 274, 276, 278, 2 83, 288–291, 294–297, 299, 30 0, 30 2 30 5, 30 9, 31 0, 31 2, 31 4, 31 6 31 8, 32 3, 32 6, 33 5, 33 6, 34 1 overviews ... 236 , 237 , 299, 30 4, 31 7 maturation phase 33 3, 33 4 measurable trait 192 measure of association 172–174, 287, 289, 291, 30 0, 30 2, 30 3, 31 0 measur...

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... the margin of the mini-rhexis, and a “normal” (third) capsulorhexis may be formed with forceps, which is blended back into the mini-capsulorhexis. CATARACT SURGERY 34 Figure 3. 9 Mini-capsulorhexis ... capsulorhexis. J Cataract Refract Surg 1997; 23: 4 73 5. 7 Pandey SK, Werner L, Escobar-Gomez M, Werner LP, Apple DJ. Dye-enhanced cataract surgery, part 3: posterior capsule staining...

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... time. Essentials of Clinical Research Part I This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research ... specifically geared to the clinical researcher interested in conducting S.P. Glasser (ed.), Essentials of Clinical Research, 3 © Springer Science + Business...

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... 10% 20% 30 % 50% Rate in the “control” treatment 2% 1.8% 1.6% 1.4% 1% 97,959 23, 2 23 9,757 3, 104 3% 2.7% 2.4% 2.1% 1.5% 64,6 73 15 ,33 9 6,447 2,0 53 5% 4.5% 4.0% 3. 5% 2.5% 38 ,044 9, 032 3, 800 1,212 ... African-American 73. 5 5.1 Age 25–44 30 35 45–64 20 22 6 5-& gt; 14 13 Median Income $ 26,700 55 ,30 0 Education <High School 25 13 High School 28 23 >High Sch...

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... in control groups of patients receiving placebo therapy. 27 ,30 ,32 ,33 ,35 ,38 ,61,65 ,33 ,37 ,39 ,40,42,45,65,70 Conversely, the condition of patients receiving placebos has also in some cases worsened. ... Project Research Group 73 planned to evaluate the efficacy and safety of several lipid-influencing drugs in the long-term treatment of coronary heart disease. This randomi...

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... Trials. May 1981; 1(4) :36 3 37 6. 9. DeMets DL, Lan KK. Interim analysis: the alpha spending function approach. Stat Med. July 15 30 , 1994; 13( 13 14): 134 1– 135 2; discussion 135 3– 134 6. 10. DeMets DL, ... 1.02] 3 −0.22 0.275 0.81 [0.47, 1 .38 ] 4 −0.22 0.1 43 0.80 [0.61, 1.06] 5 −0. 23 0.188 0.80 [0.55, 1.15] 6 0.12 0.098 1. 13 [0. 93, 1 .37 ] 166 S.P. Glasser, S. Duval almost...

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... S. Application of evidence-based urology in improving quality of care. Indian J Urol 2007; 23( 2):91–96. 22. The Problem of Induction (19 53, 1974). http://dieoff.org/page126.htm 23. Smith GC, Pell ... Petitti DB. Approaches to heterogeneity in meta-analysis. Stat Med. Dec 15, 2001; 20( 23) :36 25 36 33. 9. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test...

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... on HRT = 33 /1,700 = 0.0194 or 1.94% Conditional probability of DVT given you’re not on HRT = 27/2 ,30 0 = 0.0117 or 1.17% Joint probability of HRT AND DVT = 33 /4,000 = 0.00 83 or 0. 83% 256 S.P. ... differences in 14 Research Methodology for Studies of Diagnostic Tests 2 53 Fig. 14.6 Comparison of ROC curves Fig. 14.7 Box 1 2-1 . Receiver operating characteristic curve f...

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