Essentials of Clinical Research - part 2 doc

... Framingham Population 24 2,800 62, 910 % African-American 73.5 5.1 Age 25 –44 30 35 45–64 20 22 6 5-& gt; 14 13 Median Income $ 26 ,700 55,300 Education <High School 25 13 High School 28 23 >High School ... systematic review. Jama. Nov 2 2005 ;29 4(17) :22 0 3 -2 20 9. 14. Medical Research Council. Streptomycin treatment of pulmonary tuberculosis. BMJ. 1948;ii:76 9...

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... time. Essentials of Clinical Research Part I This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research ... controlled clinical trials. BMJ. May 25 , 1991; 3 02( 6787): 127 1– 127 2. 7. Amberson JB, MacMahon BT, Pinner M. A clinical trial of sanocrysin in pulmonary t...

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... of patients No. dead No. alive Total no. of patients No. dead No. alive 1 615 49 566 624 67 557 2 758 44 714 771 64 707 3 317 27 29 0 309 32 277 4 8 32 1 02 730 850 126 724 5 810 85 725 406 52 ... Treatment-placebo Study Mortality rate Mortality rate Diff SE of diff P-value 1 0.0797 0.1074 −0. 027 7 0.0165 0.047 2 0.0580 0.0830 −0. 025 0 0.0131 0. 028 3 0.08 52 0.1036 −0....

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... trial 27 5/1,115 22 8/1,116 0. 828 1/(0 .24 7 − ( 42 months) (24 .7%) (20 .4%) 0 .20 4) 23 .5 (24 ) ISIS 4 (5 weeks) 2, 231 /29 , 022 2, 088 /29 , 028 0.936 1/(0.0769 (7.69%) (7.19%) − 0.0719) 20 1.1 (20 2) 18 ... clinical trials? Beware the sound of sirens. Stroke 20 05; 36:1 622 –1 623 . 2. Berry D. Is the Bayesian approach ready for prime time? Yes! Stroke 20 05; 26 :...

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... Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. Nov 23 , 20 00; 343 (21 ):1 520 –1 528 , 1 522 p following 1 528 . 34. ... 28 1(13): 122 0– 122 2. 5 Postmarketing Research 75 phase III trials, nor do they provide information on long-term effectiveness and safety. All of the restrictio...

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... May 25 , 1994; 27 1 (20 ):1609–1614. 2. Benson H, Epstein MD. The placebo effect. A neglected asset in the care of patients. JAMA. June 23 , 1975; 23 2( 12) : 122 5– 122 7. 3. Melmon K, Morrelli H, Hoffman ... Services FaDA, ed. Vol 21 U.S.C. 3 52 (n). 41. Section 5 02( n) of the Food Drug and Cosmetics Act, and Title 21 Code of Federal Regulations. Vol 20 2.1(j)(1). 42. S...

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... issue 2. Chichester: Wiley; 20 07. 21 . Panda A, Dorairajan L, Kumar S. Application of evidence-based urology in improving quality of care. Indian J Urol 20 07; 23 (2) :91–96. 22 . The Problem of Induction ... inconsistency in meta-analyses. BMJ. Sept 6, 20 03; 327 (7414):557–560. 16. Chalmers I, Hedges LV, Cooper H. A brief history of research synthesis. Eval Health Prof. M...

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... conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis”. JAMA. Dec 1, 20 04; 29 2 (21 ) :26 55 26 57; discussion 26 58 26 59. 21 6 M. ... Should we use a case-crossover design? Annu Rev Public Health. 20 00; 21 :193 22 1. 54. Marshall RJ, Jackson RT. Analysis of case-crossover designs. Stat Med. Dec 30, 1993...

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... number of events not occurring (i.e. non events, or p/p-1,). So if blood type O occurs in 42% of people, the odds of someone having a blood type of O are 0. 42/ 1-0 . 42 i. e. the odds of a randomly ... differences in 14 Research Methodology for Studies of Diagnostic Tests 25 3 Fig. 14.6 Comparison of ROC curves Fig. 14.7 Box 1 2- 1 . Receiver operating characteristic...

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... 170–174, 1 92, 193, 195, 199, 20 2, 20 6, 20 7, 20 9 21 7, 22 3, 22 5 22 7, 22 9, 23 0, 23 2, 23 4 24 0, 24 2, 25 0, 26 9 27 1, 27 3, 27 4, 27 6, 27 8, 28 3, 28 8 29 1, 29 4 29 7, 29 9, 300, 3 02 305, 309, 310, 3 12, 314, ... 34–36, 44, 173, 197, 20 2, 21 4, 21 6, 23 2, 27 9, 29 6, 29 9, 303–305, 314, 316, 317 confounding 10, 30, 35, 72, 78, 134, 20 0, 20 2,...

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