Essentials of Clinical Research - part 1 doc

... time. Essentials of Clinical Research Part I This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research ... selected mile- stones in the history of clinical research include: ● Fisher’s introduction of the concept of randomization in 19 26. 5 ● The announcement...

Ngày tải lên: 14/08/2014, 11:20

... 3,800 1, 212 10 % 9% 8% 7% 5% 18 ,072 4,302 1, 815 5 81 20% 18 % 16 % 14 % 10 % 8,086 1, 937 882 266 50% 45% 40% 35% 266 2,095 518 226 77 3 Clinical Trials 37 wanted to have a representative sample of ... Heart J. Dec 19 96 ;13 2(6) :12 0 7 -1 2 21. 11 . Clark PI, Leaverton PE. Scientific and ethical issues in the use of placebo controls in clinical trials. Annu R...

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... OR 1 −0.33 0 .19 7 0.72 [0.49, 1. 06] 2 −0.38 0.203 0.68 [0.46, 1. 02] 3 −0.22 0.275 0. 81 [0.47, 1. 38] 4 −0.22 0 .14 3 0.80 [0. 61, 1. 06] 5 −0.23 0 .18 8 0.80 [0.55, 1. 15] 6 0 .12 0.098 1. 13 [0.93, 1. 37] 16 6 ... Trials. May 19 81; 1( 4):363–376. 9. DeMets DL, Lan KK. Interim analysis: the alpha spending function approach. Stat Med. July 15 –30, 19 94; 13 (13 14 ) :13 4...

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... they made the rank of full professor by age 40. The, resulting data is portrayed in Table 18 .1. From a review of Table 18 .1 what types of estimates of the measure of asso- ciation can we make ... Number of of deaths/Pts deaths/Pts RR NNT SAVE trial 275 /1, 115 228 /1, 116 0.828 1/ (0.247 − (42 months) (24.7%) (20.4%) 0.204) 23.5 (24) ISIS 4 (5 weeks) 2,2 31/ 29,022 2...

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... acceptability study in 11 ,685 patients of the efficacy of timolol/bendrofluazide in the management of hypertension in gen- eral practice. J Int Med Res. Mar–Apr 19 87; 15 (2) :10 6 11 4. 18 . Riley J, Wilton ... exclusion of the elderly and women from clinical trials in acute myocardial infarction. JAMA. Sept 16 , 19 92; 268 (11 ) :14 17 14 22. 7. Simon SD. Is the randomiz...

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... promotion. JAMA. Nov 14 , 19 90; 264 (18 ):2409–2 415 . 40. 21 CFR Part 310 section 502(a) of the Food and Drug Administration Modernization Act of 19 97 (Modernization Act) In: Department of Health and Human ... and Title 21 Code of Federal Regulations. Vol 202 .1. 43. 21 CFR Part 310 section 502(a) of the Food and Drug Administration Modernization Act of 19 97 (Mod...

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... Clin Immunol 2002 ;10 9(4):63 6-6 43; JAMA 19 97;277 (11 ):88 7-8 91; Pediatrics, 20 01; 107 (4):70 6-7 11 . Fig. 12 .4 Immortal time bias in exposed (study) and non-exposed (control) groups 19 4 S. Shrestha, ... Med J. 19 04; 3 :12 43 12 46. 6. Beecher HK. The powerful placebo. J Am Med Assoc. Dec 24, 19 55; 15 9 (17 ) :16 02 16 06. 7. Glass G. Primary, secondary and meta-ana...

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... June 1, 2007. 52. Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. Jan 15 , 19 91; 13 3(2) :14 4 15 3. 13 Implementation Research: ... AA. Clinical pharmacology of celecoxib, a COX-2 selective inhibitor. Expert Opin Pharmacother. Aug 2007; 8 (11 ) :17 19 17 32. 15 . Sun SX, Lee KY, Bertram CT, Goldstein...

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... blood-pressures (BP) multiple times and, say, average them. It may turn out that patient A’s BP was measured as 14 0, 13 2, 15 1, 14 1 mm Hg, and patient B might have measures 12 0, 12 1, 12 3, 11 9, 11 7. ... Journal of Epidemiology, 19 70 19 90. Am J Epidemiol. May 15 , 19 94; 13 9 (10 ) :10 47 10 52. 10 . Sterne JA. Teaching hypothesis tests–time for significant change? S...

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... 10 4, 10 6 10 9, 11 5 14 0, 14 9, 16 0, 16 3, 17 1, 17 2, 17 6, 235, 288 placebo control 3, 30, 31, 41, 42, 48, 54, 65, 66, 11 6, 11 7, 11 9, 12 0, 12 4, 12 5, 12 7 13 1, 13 4 14 0 placebo effect 70, 10 7, 11 5 14 1 placebo ... board (OSMB) 15 6, 16 0, 16 1 observed 34, 41, 42, 60, 11 6, 11 8 12 1, 12 8, 13 0 13 2, 16 5, 16 6, 17 1, 17 4, 18 7, 18 9, 19 1,...

Ngày tải lên: 14/08/2014, 11:20