Báo cáo y học: " Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest" pptx
Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... phosphorylation of Ó FEBS 2002 NAMI-A affects c-myc gene expression and MEK/ERK phosphorylation (Eur. J. Biochem. 269) 5869 Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A ... counteracted, and ultimately abolished, the increase in c-myc gene expression elicited by PMA in serum-free cells. These results suggestthat inhibition of MEK/ERK signaling by NAMI-A mayhave an ... heavily suggests that the inhibitory effect of NAMI-A on c-myc gene expression mayhave occurred by suppressing ERK1/2 activation and activity elicited by PMA-generated signals.Unlike the ras gene...
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by thesubstitution, ... [31].RESULTSErythromycin, Cl-tetracycline and streptomycin inhibit nuclear splicing in vitro The effects of eight different antibiotics (the aminoglycoside,kanamycin, the a minocyclitol glycoside, streptomycin, ... RNA by 9%only (lane 3). T he other three antibiotics, Cl -tetracycline,streptomycin and erythromycin, are clearly inhibitors of nuclear pre-mRNA splicing, as indicated by a largereduction in...
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... suggest that the inhibition of HA production was not caused by direct inhibition of HAS activity.Effect of MU on HAS activity in FM100 cells treatedwith MUThe activity of the HAS in FM100 cells ... n-dodecyl-b-D-maltoside;GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HA, hyaluronan (hyaluronic acid); HABP, hyaluronan binding protein;HAS (Has), hyaluronan synthase; MU, 4-methylumbelliferone; spHAS, S. pyogenes ... thelipid environment of membranes, especially the distribution of different cardiolipin species, surrounding hyaluronan synthase.Keywords: hyaluronan; synthesis; Streptococcus; 4-methyl-umbelliferone;...
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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... into contact in the absence of ATP, curcumin is then able tobind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding(i.e. inhibiting ... point is the mean ^ SD of three determinations.q FEBS 2001 Inhibition of the Ca2ỵ-ATPase by curcumin (Eur. J. Biochem. 268) 6323 Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively ... possiblyincreased. In order to further assess the possibility of curcumin affecting the interaction of ATP binding to the ATPase, thiswas directly measured using [32P ]ATP in the absence of Ca2ỵ(Fig....
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Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot
... transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosinekinases and protein kinase C by inositolglycan and diacylglycerolmoieties. ... to study GPtdIns biosynthesis in a variety of cell-types and organisms. In all systems investigated so far,mannosamine was able to inhibit GPtdIns biosynthesis. In T. brucei, mannosamine inhibits ... study glycosylphosphatidylinositol (GPtdIns) biosynthesis and GPtdIns protein anchoring in protozoaland mammalian systems. The effects of these analogues onGPtdIns biosynthesis and GPtdIns-protein...
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Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... 2002 Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+ -binding ... Ca2+ binding and phosphoryl transfer and postulate that the drugbinds to and interferes with the Ca2+entry pathway of the Ca2+-ATPase.MATERIALS AND METHODS2-Aminoethoxydiphenylborate ... M3, M4, M5 and M7. The binding of 2-APB to these sites could influence the movement of the loop between M6 and M7 (L6-7), and reduce access of Ca2+ to their binding sites. Keywords :2-APB; Ca2+-ATPase;...
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Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... H Open AccessInhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cellsDuo-Rong ... VX-680 inhibits activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur-A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing ... stem cells and induces leukemia in mice. Blood 2010, 115:1406-15.doi:10.1186/1479-5876-9-74Cite this article as: Xu et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces...
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báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt
... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. Journal of Translational ... H Open Access Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cellsDuo-Rong ... VX-680 inhibits activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur-A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing...
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Báo cáo y học: "Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis" potx
... pathogenesis of RA. The principal plasma inhibitor of thrombin is antithrombin, asingle-chain 51 kDa glycoprotein that is synthesized in liver. The inhibitory activity of antithrombin on thrombin is ... presence of HA, supporting the notion that HA could compete withheparin for the heparin-binding region of antithrombin. Remarkably, HA affected the inhibition by antithrombin onlywithin the range ... molecularstructure of HA is analogous to that of heparin, HA mightexert its effect by binding to the heparin-binding region of antithrombin. However, such binding did not stimulate the activity of antithrombin...
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Báo cáo y học: "Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice" docx
... of inhibitors of uptake on the intracellular processing of type II collagen (CII) by dendritic cellsThe effect of inhibitors of uptake on the intracellular processing of type II collagen (CII) ... cells by inhibition of antigen uptake in HLA-DR1- transgenic mice in vitro and in vivo. Electronmicroscopy, confocal microscopy, subcellular fractionation and antigen presentation assays were ... prevents macropinocytosis, inhibitedintracellular accumulation of CII and antigen presentation of the major arthritogenic T cell epitope in both glycosylated and non-glycosylated forms. In addition,...
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Báo cáo y học: "Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts" pdf
... restores the viability of synovial fibroblasts in the presence of statinsGeranylgeranylpyrophosphate (GGPP) restores the viability of synovial fibroblasts in the presence of statins. Synovial fibroblasts ... in viability in the presence of statins.Geranylgeranylpyrophosphate restores the viability of RA synovial fibroblasts in the presence of statinsThe decrease in cellular viability caused by ... in all aspects of the patho-genesis of arthritis. Hyperplasia of the synovial lining in RA isdue primarily to increases in the number of synovial fibroblasts.Although the reason for this increase...
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Báo cáo y học: "Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists" pdf
... anti-mycobacterial CD4+ T lymphocytes. Administered in vivo, theydecrease the frequency of the subpopulation of memory CD4+T lymphocytes rapidly releasing IFN-γ upon challenge with mycobacterial ... activation of CD4+ T lymphocytes bymycobacterial antigens, presumably reflecting their higherpotency in interacting with mTNF expressed by activatedCD4+ T lymphocytes. Such a dual effect may explain ... these lymphocytes were presumably resting mem-ory T lymphocytes at the moment of blood collection. To ana-lyse the effect of TNF antagonists on the activation of anti-mycobacterial CD4+ T lymphocytes,...
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Báo cáo y học: " Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice" doc
... 1 of 7(page number not for citation purposes)Vol 9 No 3Research article Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in ... work is properly cited.Abstract Indoleamine 2,3-dioxygenase (IDO) is one of the initial and rate-limiting enzymes involved in the catabolism of the essentialamino acid tryptophan. In cultured ... (1-MT) in vivo. The results showedsignificantly increased incidence and severity of CIA in micetreated with 1-MT. Activity of IDO, as determined by measuringthe levels of kynurenine/tryptophan...
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Báo cáo y học: "Inhibition of hyaluronan export reduces collagen degradation in interleukin-1 treated cartilage" pot
... threeinhibitors.Figure 1Inhibition of hyaluronan export in bovine chondrocytesInhibition of hyaluronan export in bovine chondrocytes. (a) Cartilage explants were incubated in the absence and presence of IL-1α ... drugs inhibited hyaluronan export, but they didnot inhibit hyaluronan synthase activity. Simultaneously, theyinhibited proteoglycan loss and collagen degradation, but nottheir synthesis. They ... fromproteolytic degradation [50]. As a consequence of this sce-nario, collagen is protected from degradation by inhibition of hyaluronan export. We also analyzed the mechanism of hyaluronan export inhibi-tion....
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Báo cáo y học: " Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest" pptx
... Genome Biology 2008, 9:R92Open Access2008Yang and StockwellVolume 9, Issue 6, Article R92Research Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrestWan ... PER3, CRY1, and CRY2 for suppressingIC261-induced growth arrest.Additional data file 1Growth inhibitory activity of all shRNAs used in this study, statisti-cal analysis, and list of hitsGrowth ... images of samples, and analysis of theimages were carried out automatically by Vi-Cell (BeckmanCoulter).Monitoring drug sensitivityOn the day of the experiment, empty 384-deep-well polypro-pylene...
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