Báo cáo y học: " Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest" pptx

... phosphorylation of Ó FEBS 2002 NAMI-A affects c-myc gene expression and MEK/ERK phosphorylation (Eur. J. Biochem. 269) 5869 Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A ... counteracted, and ultimately abolished, the increase in c-myc gene expression elicited by PMA in serum-free cells. These results sug...

Ngày tải lên: 21/02/2014, 01:21

... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, ... [31]. RESULTS Erythromycin, Cl-tetracycline and streptomycin inhibit nuclear splicing in vitro The effects of eight different antibiotics (the amino...

Ngày tải lên: 21/02/2014, 15:20

... suggest that the inhibition of HA production was not caused by direct inhibition of HAS activity. Effect of MU on HAS activity in FM100 cells treated with MU The activity of the HAS in FM100 cells ... n-dodecyl-b- D -maltoside; GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HA, hyaluronan (hyaluronic acid); HABP, hyaluronan binding protein; HAS (Has), hyaluron...

Ngày tải lên: 08/03/2014, 09:20

... into contact in the absence of ATP, curcumin is then able to bind to the ATPase (possibly at the hinge region) locking the two domains together and therefore precluding ATP binding (i.e. inhibiting ... point is the mean ^ SD of three determinations. q FEBS 2001 Inhibition of the Ca 2ỵ -ATPase by curcumin (Eur. J. Biochem. 268) 6323 Inhibition of the...

Ngày tải lên: 08/03/2014, 23:20

... transduction in macrophages by glycosylphosphatidylinositols of Plasmodium, Trypanosoma, and Leishmania: activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties. ... to study GPtdIns biosynthesis in a variety of cell-types and organisms. In all systems investigated so far, mannosamine was able to inhibit GPtdIns biosynthes...

Ngày tải lên: 31/03/2014, 23:20

... 2002 Inhibition of SERCA Ca 2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca 2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca 2+ -binding ... Ca 2+ binding and phosphoryl transfer and postulate that the drug binds to and interferes with the Ca 2+ entry...

Ngày tải lên: 31/03/2014, 23:20

... H Open Access Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Duo-Rong ... VX-680 inhibits activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur- A at Thr288 in NB4-...

Ngày tải lên: 18/06/2014, 19:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. Journal of Translational ... H Open Access Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all...

Ngày tải lên: 20/06/2014, 03:20

... pathogenesis of RA. The principal plasma inhibitor of thrombin is antithrombin, a single-chain 51 kDa glycoprotein that is synthesized in liver. The inhibitory activity of antithrombin on thrombin is ... presence of HA, supporting the notion that HA could compete with heparin for the heparin-binding region of antithrombin. Remarkably, HA affected the inhibition b...

Ngày tải lên: 09/08/2014, 06:22

... of inhibitors of uptake on the intracellular processing of type II collagen (CII) by dendritic cellsThe effect of inhibitors of uptake on the intracellular processing of type II collagen (CII) ... cells by inhibition of antigen uptake in HLA-DR1- transgenic mice in vitro and in vivo. Electron microscopy, confocal microscopy, subcellular fractionation...

Ngày tải lên: 09/08/2014, 08:22

... restores the viability of synovial fibroblasts in the presence of statinsGeranylgeranylpyrophosphate (GGPP) restores the viability of synovial fibroblasts in the presence of statins. Synovial fibroblasts ... in viability in the presence of statins. Geranylgeranylpyrophosphate restores the viability of RA synovial fibroblasts in the presence of statins The dec...

Ngày tải lên: 09/08/2014, 08:22

... anti- mycobacterial CD4 + T lymphocytes. Administered in vivo, they decrease the frequency of the subpopulation of memory CD4 + T lymphocytes rapidly releasing IFN-γ upon challenge with mycobacterial ... activation of CD4 + T lymphocytes by mycobacterial antigens, presumably reflecting their higher potency in interacting with mTNF expressed by activated CD4 + T lymphocytes. Such...

Ngày tải lên: 09/08/2014, 08:22

... 1 of 7 (page number not for citation purposes) Vol 9 No 3 Research article Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in ... work is properly cited. Abstract Indoleamine 2,3-dioxygenase (IDO) is one of the initial and rate- limiting enzymes involved in the catabolism of the essential amino aci...

Ngày tải lên: 09/08/2014, 10:20

... three inhibitors. Figure 1 Inhibition of hyaluronan export in bovine chondrocytesInhibition of hyaluronan export in bovine chondrocytes. (a) Cartilage explants were incubated in the absence and presence of IL-1α ... drugs inhibited hyaluronan export, but they did not inhibit hyaluronan synthase activity. Simultaneously, they inhibited proteoglycan loss and collagen...

Ngày tải lên: 09/08/2014, 10:22

... Genome Biology 2008, 9:R92 Open Access 2008Yang and StockwellVolume 9, Issue 6, Article R92 Research Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest Wan ... PER3, CRY1, and CRY2 for suppressing IC261-induced growth arrest. Additional data file 1Growth inhibitory activity of all shRNAs used in this study, statisti-cal...

Ngày tải lên: 14/08/2014, 08:21