Báo cáo y học: "What makes pathogens pathogenic" pdf

... reaction-centered graphs of the type o f Graph 1 (these paths may contain parallel and antiparallel arrows). The sign of that element therefore depends on the both the sign and the magnitudes of these influen ce paths ... the kinetic parameters t hat enable such oscillations. The main result of such an analysis is that oscillations arise if t he parameter k 3 is the l a...

Ngày tải lên: 19/02/2014, 16:20

... 2002 Natively unfolded proteins (Eur. J. Biochem. 269)5 REVIEW ARTICLE What does it mean to be natively unfolded? Vladimir N. Uversky 1 Institute for Biological Instrumentation, Russian Academy ... ean hydrophobicity and/or net charge of the natively unfolded polypeptide. In fact, any interaction of such protein with natural ligand affecting mean net c harge and/or mea...

Ngày tải lên: 08/03/2014, 16:20

... inherent in evaluation through user testing. It does, however, have some unpleasant attributes. First, it does not provide an easy basis for comparison of systems. Ideally an evaluation would ... process. The taxonomy approach faces the problem of complexity directly. The taxonomy approach to evaluation forces examination of the broad range of issues of natural language process...

Ngày tải lên: 17/03/2014, 19:20

... assessed the impact of treatment with adalimumab on serum MMP3, VEGF, and bone specific alka- Editorial What do biomarkers tell us about the pathogenesis of ankylosing spondylitis? Walter P Maksymowych Department ... inflammatory changes in the spine predict the development of new syndesmophytes, complete resolution of inflammation at a vertebral corner following...

Ngày tải lên: 09/08/2014, 01:22

... with an increased risk of SLE include history of hypertension, drug allergy, type I/II sun- reactive skin type, and blood transfusions (all moderately increasing the risk) and family history substantially ... epidemiology has told us about risk factors and aetiopathogenesis in rheumatic diseases Jacqueline E Oliver and Alan J Silman Arthritis Research Campaign,...

Ngày tải lên: 09/08/2014, 01:22

... decades there has been a growing realization that the traditional outcome domains of symptom reduction and safety are inadequate when Commentary What should be the core outcomes in chronic pain clinical ... someone’s pain is by what they say or show by their behavior. There is an assumption that pain is highly associated with emotional and physical functioning and that...

Ngày tải lên: 09/08/2014, 01:23

... injury to chronic pain. Conversely, traditional animal and clinical models employed to screen for analgesics might not be useful for studying the transition from acute injury to chronic pain if the ... events occur days after the injury when acute pain is usually resolving symptomatically. This limitation is even more important if these same pain models are not able to identify an...

Ngày tải lên: 09/08/2014, 06:22

... status, Review Aspects of early arthritis What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register Deborah PM Symmons and Alan J ... unnecessary risk to give them intensive DMARD therapy or even biologic therapy. On the other hand, some patients do very badly and fail t...

Ngày tải lên: 09/08/2014, 08:22

... Arthritis Rheum 2002, 46:507-513. 30. Proulx S, Kwok E, Shealy DJ, Ritchlin CT, Schwarz EM: Under- standing bone marrow edema in arthritis: 3D -MRI and histol- ogy analyses of TNF-Tg mice. Arthritis ... the road to unraveling the mystery of what MRI bone oedema actually means in RA. The implications are exciting and suggest a new focus for understanding disease patholo...

Ngày tải lên: 09/08/2014, 08:23

... facilitate the institution of an appropriate system. Although the frequency of these lesions is low, they may have clinical significance and may be the first sign of life-threatening disease. Researchers ... lesions, incidental to the pur- pose of the imaging, are not missed. There may be a number of ways of providing this function apart from review by a mus- c...

Ngày tải lên: 09/08/2014, 10:22

... -10,163 Rofecoxib 1.26 2.13 0.64 1,563 Any dose of drug was allowed in the data, and the table additionally shows the rate and frequency of additional events. The calculations used a mortality rate of ... from the meta-analysis for NSAIDs, and an average figure from observational studies for coxibs. We used relative Figure 4 Risk of myopathy, rhabdomyolysis a...

Ngày tải lên: 09/08/2014, 10:23

... magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years Dennis McGonagle and Ai Lyn Tan Academic Unit of Musculoskeletal Disease, University ... autoantibody- associated RA is primarily a disorder of synovium. This emphasises the importance of the effective treatment of synovitis as being the on...

Ngày tải lên: 09/08/2014, 13:22

... and the disease caused by it, AIDS. Many of them are now accessible online. However, we are launching the first Open Access journal in the AIDS arena – AIDS Research and Therapy. The purpose of ... any other barriers to access. In an Open Access journal, the communication has to be bi-direc- tional for the journal's success and improving the quality of the...

Ngày tải lên: 10/08/2014, 05:20

... display enormous phenotypic and genotypic heterogeneity [7]; microbial colonization is nearly univer- sally polyclonal [8-11]; and microbiomes occupying the same niche in different hosts are vastly ... 118899:: 8186-8195. 29. Buchinsky FJ, Forbes M, Hayes J, Hu FZ, Greenberg P, Post JC, Ehrlich GD: PPhheennoottyyppiicc pplluurraalliittyy aammoonngg cclliinniiccaall ssttrraaiinnss ooff nnoon...

Ngày tải lên: 14/08/2014, 08:21

... in any medium, provided the original work is properly cited. Proteins with obscure features<p>An analysis of proteins with obscure features in ten eukaryotic genomes revealed that the majority ... to nearly every eukaryotic gene. Noticeably lacking from the comparative analysis of eukaryo- tic genomes to date, however, is an analysis of the origins and function...

Ngày tải lên: 14/08/2014, 16:21