Báo cáo y học: "Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice" ppt

... loci. The timing of the oldest divergence amongst the lineage of these genes is esti- mated at 11.2-22.4 Mya between genes 16 and 19; the timing of the minimum at 4.4-8.8 Mya between genes 18 and ... about the evolution of the Mup gene family, in particular regarding the relationship between urinary MUPs and non -urinary MUPs, and between those MU...

Ngày tải lên: 14/08/2014, 08:21

... this subgroup of infected persons [4] Since in the absence of anti-retroviral therapy (ART), the HIV-1 replication capac- ity (RC) is largely related to the efficiency of viral entry [5,6]-, the selective ... recognized by this broad neutralizing antibody on the gp120 surface [34]. Identification of rare mutations When the amino acid entropy of positively selected site...

Ngày tải lên: 13/08/2014, 05:21

... and the phosphates of the cap structure, or of the backbone of the RNA, thereby reducing the affinity of eIF4E for its ligand and potentially opening up the cap-binding cleft. 5354 G. C. Scheper and ... eIF4E phosphorylation will be determined by two factors. The first is the state of activation of the Erk or p38 MAP kinase pathways, which regulate the act...

Ngày tải lên: 23/03/2014, 21:20

... mice were pro- duced by a deletion in the IL-10 gene in a cross of C57BL/ 6 × 129/ Ola (originally provided by W Müller, Institute of Genetics, Cologne, Germany). They were further back- crossed ... scores. Among mice of the QD strain, individuals that subsequently developed cyanosis lost as much as 25% of their body weight within a few days after the onset of respirat...

Ngày tải lên: 09/08/2014, 01:24

... replace the wild type segment. The pNL4.3LucE - R - vector (containing the luciferase reporter gene and deficient for Env and Vpr synthesis [26]) was generously provided by Dr N.R. Landau. The pNL4.3AsLucE - R - vector ... characterize the ASP protein, its expression and localization were analyzed in Jurkat cells. Analysis of its amino acid sequence reveals a highly hyd...

Ngày tải lên: 13/08/2014, 01:21

... 1). Identification of putative regulatory elements within the xMGP gene promoter The 5 ¢ flanking sequence of the xMGP gene is typ ical for a RNA polymerase II transcribed gene. Immediately upstream from the ... (including the vitamin D, retinoic acid and thyroid hormone receptors) did not modulate the activity of the )949LUC reporter significantly, either in presence...

Ngày tải lên: 08/03/2014, 10:20

... correlation between virulenceandgrowthrateofthepathogen[18,19],theygiveimportantinsightinto pathogenesis. Models of infection pathogenesis The complexity of the models increases when they aim to ... complexity of these models is dependent on the number of components and the temporal resolution in the model. We comment on the specific use of simple and complex model...

Ngày tải lên: 13/08/2014, 16:20

... prototype model and the previous models developed by others contain only three metabolic pathways, namely, the glycolysis pathway, the pentose phosphate pathway and the nucleotide metabolic pathway. ... Schubert D: The complex of band 3 protein of the human erythrocyte membrane and glyceraldehyde-3- phosphate dehydrogenase: stoichiometry and competition by aldola...

Ngày tải lên: 13/08/2014, 22:22

... confirmed by Western blot described below; and the cell death rate was exam- ined by the trypan blue method after 24 and 48 hr of transfections, respectively. Western blot of PR domain The expression ... expression of the PR domain was examined after 24 hr of transfection with pcDNA/HisMax/PR and the empty vector, respectively. Supernatants (30 g) of the...

Ngày tải lên: 25/10/2012, 11:15

... During the therapeutic process, real-time estimation of the therapeutic effect was carried out by the computer system through the graphic changes in the target field and the hyperecho of the ... consisting primarily of lymphocytes and monocytes sometimes with small number of eosinocytes, were seen between the necrotic and normal zones. In addi- tion, hy...

Ngày tải lên: 25/10/2012, 11:18