Báo cáo y học: "Loss of genes implicated in gastric function

Báo cáo y học: "Loss of genes implicated in gastric function during platypus evolution" docx

... subunit ++ - Mucins - Chymosin - Enterokinase Enterocytes, Brunner, K cells - Gastric inhibitory polypeptide - Vasoactive intestinal polypeptide - Cholecystokinin Intestine Genome Biology 2008, 9:R81 http://genomebiology.com/2008/9/5/R81 ... observed in platypus gastric genes do not represent a general process affecting all proteins that are involved in food digestion, because ana...

Ngày tải lên : 14/08/2014, 08:21

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Báo cáo y học: " Role of clinical bioinformatics in the development network-based Biomarkers" docx

... (nGNTInfer), inferring transcriptional regulatory networks from high-throughput data (nTRNInfer), inferring protein-protein interactions by parsimony principle (nInferPPI), inferring protein-protein ... or incorrectly functioning cells, tissue, organ, or system of the body, involved in multiple proteins, cells, organs and systems with the complexity. There still remains the poor unde...

Ngày tải lên : 10/08/2014, 09:22

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Báo cáo y học: "Influence of metabolic network structure and function on enzyme evolution" pptx

... Highly connected proteins in protein interaction networks may evolve slowly because a larger fraction of a highly connected protein's sequence is involved in protein interactions and may ... enzymes. In the long run, system analyses of biological networks will allow us to increasingly place the evolution of genes in the larger context in which they operate, as buildin...

Ngày tải lên : 14/08/2014, 16:21

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Báo cáo Y học: Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells deﬁne structural determinants of receptor function doc

... stimulations of adenylyl cyclase were only obtained at high agonist doses (Fig. 6A), consistent with a loss of binding afﬁnity observed in radioligand binding assays (Fig. 6B). This reduced afﬁnity for ... sequences of MC1R were tagged by adding a (HA) 2 His 6 tag to the C-terminus of the protein. This tag corresponds to the sequence RFYPYDVPDYAGYPYDVPDYAHHHHHH, placed immediately a...

Ngày tải lên : 17/03/2014, 10:20

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Báo cáo y học: "Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as control" doc

... MAF = minor allele frequency; Ref = reference; SNP = single nucleotide polymorphism. a combination of initial finding and replication (when available) in the cited study; effects from minor allele. b ... described [16]. In brief, for each genotyping experiment 10 ng DNA was used in a total volume of 5 μl containing 1 × TaqMan ® Genotyping Master Mix (Applied Biosystems Foster Ci...

Ngày tải lên : 09/08/2014, 14:20

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Báo cáo y học: " Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in miceg" pdf

... blunting of TF diet- induced weight gain, hyperinsulinemina, and hyperglyce- miainmicewithlossoffunctionmutationinTLR4, our results in this study do not directly contradict the previously proposed ... exacerbated in the presence of loss of function mutation in TLR4. Furthermore, our results indicate that TLR4 independent pathways may be involved in TF-diet-induced obesity, hyp...

Ngày tải lên : 11/08/2014, 03:20

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Báo cáo y học: "Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice" docx

... blunting of TF diet- induced weight gain, hyperinsulinemina, and hyperglyce- miainmicewithlossoffunctionmutationinTLR4, our results in this study do not directly contradict the previously proposed ... exacerbated in the presence of loss of function mutation in TLR4. Furthermore, our results indicate that TLR4 independent pathways may be involved in TF-diet-induced obesity, hyp...

Ngày tải lên : 11/08/2014, 06:22

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Báo cáo y học: "Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference" pps

... subset of the genetically related synMuv B family of chromatin- modifying genes, show increased strength and penetrance for many germline, embryonic, and post- embryonic RNAi phenotypes, including ... subclassification of synMuv B genes is functionally relevant. Inactivation of a subset of synMuv B genes results in ectopic expression of a lag-2::gfp reporter gene [26]. Stri...

Ngày tải lên : 14/08/2014, 16:20

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Báo cáo y học: "Clustering of genes into regulons using integrated modeling-COGRIM" ppsx

... probability that TF j physically binds in proximity to gene i in a ChIP binding experiment, and m ij , the probability of a binding site for TF j in the upstream region of gene i. The sec- ond level of ... only potential binding sites that may not be bound by TFs, and ChIP binding data pro- vides only physical binding information that may not be func- tional in terms of contro...

Ngày tải lên : 14/08/2014, 17:22

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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"

... with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance...

Ngày tải lên : 25/10/2012, 11:48

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