Báo cáo y học: "Finishing the finished human chromosome 22 sequenc" pptx

... G. Berrin et al. (Eur. J. Biochem. 269) Ó FEBS 2002 Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides Jean-Guy ... it might have a role in human aging [6]. Finally, a b-glucosidase, termed cytosolic b-glucosidase, is present in the liver, kidney...

Ngày tải lên: 08/03/2014, 16:20

... Arg16 and Glu20. The biological impact of the Aib1 5 and D -Phe12 modifications on the synthetic CRH analogue is illustrated by the peptide binding affinity enhancement towards the CRH receptor and ... towards the design and synthesis of new molecules with higher binding affinity and enhanced stability against biological degradation and possibly biological ac...

Ngày tải lên: 17/03/2014, 10:20

... understand the enzymatic mechanism of this novel enzyme, and to facilitate inhibitor screening of human TDP, we have expressed and purified recombinant human TDP variants carrying deletions of 1–39 ... human TDP variants was approximated to be 5 mgặL )1 of E. coli culture (Fig. 2). TDP is involved in the Topo I DNA repair pathway, and inhibitors of TDP may have th...

Ngày tải lên: 31/03/2014, 21:21

... individual. This comparison allowed us to directly evaluate the sensitivity and specificity of RNA- Seq in identifying coding variants, and to evaluate how key parameters such as the degree of coverage ... that at only one lane of RNA-Seq data, the specific- ity was 0.5 for SNVs with a read depth of 3, which was far better than the value of 0.28 found when using all...

Ngày tải lên: 09/08/2014, 20:22

... the early expression of PAX6 in humans (similar to their previous results with rhesus monkey embryonic stem cells), may have been a step in the evolution of the highly evolved forebrain of ... dataset they gener- ated to compare the gene-expression profile of human embryos with that of human embryonic stem cells (hESCs) maintained in culture. ey found that ap...

Ngày tải lên: 09/08/2014, 20:22

... respectively. Interestingly, there is no overlap in candidate regions identified in the two populations. When the authors restrict their analysis to candidate genes and pathways involved in high- altitude ... EPAS1, on the other hand, was only identified in the Tibetan populations, and PPARA was not considered with the HIF pathway genes in the Andean analysis, so it remains...

Ngày tải lên: 09/08/2014, 20:22

... Research and Therapy Open Access Review Bacterial vaginosis and human immunodeficiency virus infection Gregory T Spear*, Elizabeth St John and M Reza Zariffard Address: Department of Immunology/Microbiology, ... Spear GT: Activation of human immunodeficiency virus type 1 expression by Gard- nerella vaginalis. J Infect Dis 1999, 179:924-930. 39. Al-Harthi L, Roebuck KA, Oli...

Ngày tải lên: 10/08/2014, 05:20

... Unfortunately, RU24858 does not dissociate between transactivation and transrepression in human eosinophils and thus is not suitable for evaluation of sig- nalling in human eosinophils. In the present ... number not for citation purposes) Journal of Inflammation Open Access Research The glucocorticoid RU24858 does not distinguish between transrep...

Ngày tải lên: 11/08/2014, 08:21

... 10 of 13 RESEA R C H ART I C L E Open Access Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis Yanying Liu 1† , Rong Mu 1† , Shiyao ... signature cytokine for Tregs, and plays a key role in the control of self-antigen-reactive T cells in vivo [38]. The upregula- tion of IL-10 is in line wi...

Ngày tải lên: 12/08/2014, 15:22

... height of the plasma containing chamber MW Molecular weight of the compound r Inner radius of the plasma containing chamber V P Calculated volume of plasma in the dialysis unit On basis of the calculated ... limit of quantifica- tion of the assay was 20 ng/mL for all glucocorticoids. Calculation of the fraction of applied dose determined in plasma The amoun...

Ngày tải lên: 12/08/2014, 18:21

... hybridization quality, and for the normalization of the arrays (Additional data file 6). Hybridization and pre-processing of the data Hybridizations and scanning of the arrays were performed at the ... interactions information Open Access 2007Zhanget al.Volume 8, Issue 5, Article R86 Research Characterizing the expression of the human olfactory receptor gene f...

Ngày tải lên: 14/08/2014, 07:21

... 8, Article R158 Research Quantifying the major mechanisms of recent gene duplications in the human and mouse genomes: a novel strategy to estimate gene duplication rates Deng Pan and Liqing ... 8,312 in human and 8,105 in mouse are single-copy genes, and the remaining are clus- tered by Ensembl into 3,538 families in human and 3,60...

Ngày tải lên: 14/08/2014, 08:20

... are already likely to represent relatively common haplotypes because of the nature of human polymorphism [27,33,34]. Similarly, the availability of additional sequence of this type may provide ... the outstanding gaps in the human genome sequence. Background The completion of the human genome sequence was the cul- mination of the 15 year Human Genome Project. The fi...

Ngày tải lên: 14/08/2014, 08:21

... the 3-hydroxybutyryl-CoA dehydratase reaction in the lysine degradation and tryptophan degradation pathways. The dihy- drofolate synthase hole in formylTHF biosynthesis was filled by the enzyme ... bound on the total number of human metabolic pathways; this number excludes the 10 HumanCyc superpathways that are defined as linked clusters of pathways. The average lengt...

Ngày tải lên: 14/08/2014, 14:21

... medium, provided the original work is properly cited. Consolidating the set of known human protein-protein interactions& lt;p> ;In order to consolidate the known human proteins interactions two tests ... protein interactions. Comparison of extracted interactions with existing interactionsFigure 5 Comparison of extracted interactions with existing interacti...

Ngày tải lên: 14/08/2014, 14:21