Báo cáo y học: " Epigenomes under scrutiny" ppsx

... methylation between pluripotent cells and their differentiated derivatives. The alterations observed occurred primarily at CpG-poor promoters, which under- went dynamic methylation and demethylation. ... and colleagues examined the dynamics of DNA methylation as mouse embryonic stem cells (ES cells) progress to neural precursors and neurons in vitro. Intriguingly, very little change was fou...

Ngày tải lên: 14/08/2014, 08:21

... vibra- tory urticaria are very rare. In physical urticaria the routine diagnosis is mainly limited to identify the subtype by appropriate standardized challenge tests [68]. The association of physical ... serology for streptococci (antist- reptolysin, antiDNase B), staphylococci (antistaphy- lolysin), yersinia (IgA, IgG, immunoblot). If an infection is identified, it should be appropriately t...

Ngày tải lên: 08/08/2014, 21:20

... ENPP1 variants should be genotyped in patients with severe disease at the hip, knee, or spine. The osteoarthritis research community is relatively fortunate in that many groups have collected OA ... OA cohorts suitable for genetic analyses [6], making confirmatory studies feasible. The genetic investigation of osteoarthritis has had a fillip in recent years, with compelling associations ... r...

Ngày tải lên: 09/08/2014, 07:20

... S. pyogenes infection [2]. One consequence of the cytokine storm induced by superantigens may be to disrupt the development of antibody-mediated immunity. By switching off superantigenicity, the ... staphy- lococcal exotoxin B and toxic shock syndrome toxin 1, which have only 6% sequence homology. This is hard to understand in terms of neutralizing antibody since no cross-reactivity between ....

Ngày tải lên: 12/08/2014, 18:20

... not have xyloglucan endotransgly- cosylase (XET) activity and that XET lacks wall extension activity, either by itself or in the presence of xyloglucan oligosaccharides. 68. Yuan S, Wu Y, Cosgrove ... http://genomebiology.com/2005/6/12/242 Genome Biology 2005, 6:242 Expansins do not have hydrolytic activity or any of the other enzymatic activities yet assayed [64,66,67]. A report that they...

Ngày tải lên: 14/08/2014, 15:20

... University, Cambridge, USA) brought aspects of protein expression, abundance and stability into focus in her talk on yeast physiology, which included an impressive systematic analysis of extremely large ... protein arrays, affinity separation techniques, in vivo analysis, and so on. Matthias Uhlen (Royal Institute of Technology, Stockholm, Sweden) underlined the importance of properly validat...

Ngày tải lên: 14/08/2014, 15:20

... the Panther (Protein analysis through evolutionary relationships) Pathways database [http://www.pantherdb.org/pathway] by Paul Thomas (Applied Biosystems, Foster City, USA), we saw integration ... significantly between lines. Matthew Vaughn (Cold Spring Harbor Laboratory, Cold Spring Harbor, USA) pre- sented large-scale DNA methylation data from Arabidopsis. A key approach to understanding .....

Ngày tải lên: 14/08/2014, 16:21

... should be shortened to 15 pages. If you can’t describe clearly in 15 pages what you’ve already done, what you intend to do, and why it’s important, you probably can’t do it in 50. But I think ... haven’t had any experience writing proposals and anyway usually end up doing something different, or in a very different way, from what they propose. Instead, fellowship reviewers tend to consider ....

Ngày tải lên: 14/08/2014, 16:21

... early mouse embryos and in marsupials, the paternal X chromosome is always inactivated. In this type of imprinted dosage regulation the paternal X chromosome may be originally identified by its unpaired ... chromosome within a specific nuclear compartment may also play a role for its identification, but all these hypotheses ultimately hinge on the ability to distinguish the DNA of the X chrom...

Ngày tải lên: 14/08/2014, 17:22

... transcription factor activity. Harman Bussemaker (Columbia University, New York, USA) des- cribed a way of detecting post-transcriptional modifications of transcription factor activity by using a statistical mechanics ... biology is driven by interactions between proteins, DNA and RNA, networks are a natural way to repre- sent these systems. A recent network biology meeting in Hinxton was att...

Ngày tải lên: 14/08/2014, 21:20