Báo cáo y học: "A rational approach to cancer therapy" pot

... a combination of apoptosis and delayed toxicity via auto- phagy. Interestingly, autophagy continued to occur even when the drug was removed after the initial treatment, thereby decreasing side effects. One ... identify those combinations that provide synergism, thus increasing selectivity and potency as well as reducing genotoxicity and side effects. Drug combinations, this time targeting t...

Ngày tải lên: 14/08/2014, 08:21

... Sci. 2006, 3 65 underlying autoimmune diseases, thyroid disorders, pregnancy, etc. In addition, the history can identify other factors such as alcohol use or abuse which may suggest possible ... strategies. 2. Natural History of HCV Infection The natural history of HV infection was thoroughly reviewed by Drs. Chen and Morgan in this issue. Knowing the natural history of HCV infection...

Ngày tải lên: 02/11/2012, 09:51

... improved histology. The overall response to one year of ADV treatment as determined by HBeAg seroconversion is approximately 12% (vs. 6% in placebo group) that could be increased to 23% by the end ... sensitive to LAM treatment [16]. 4. Indications of HBV Treatment Historically, levels of HBV DNA and ALT, and histological activity of liver biopsy have been used as the three main fact...

Ngày tải lên: 03/11/2012, 09:41

... inflammatory state of the disease Extracellular proteases are secreted in SF by infiltrating inflam- matory cells and/or by stromal cells stimulated by inflammatory cytokines [21,22]. To assess ... (MMP-9) activity using immobilized fluorescent substrate on microspheres. Cytometry 1996, 25:374-380. 17. Kitano T, Ohashi H, Kadoya Y, Kobayashi A, Yutani Y, Yamano Y: Measurement of ζ pote...

Ngày tải lên: 09/08/2014, 08:22

... light-dark cycle was reversed every 48 hours (as if this group of rats instantly travelled back and forth from Asia to the Americas every other day). Animals were housed individually and allowed to eat ... 3). The transforma- tion was employed to estimate the functional input to the human circadian system, which appears to apply to both light-induced nocturnal melatonin suppressio...

Ngày tải lên: 10/08/2014, 09:20

... only in the initial diagnostic stage, it is also an effective tool to monitor the treatment effectiveness and reparative pro- cesses related to tennis leg [1,3,6]. Surprisingly, the usual hyperechoic ... image examined approximately 17 days after the initial injury revealed a well-defined anechoic fluid collection (grey arrow) site and some hypoechoic areas (dotted grey arrow). Figure 3....

Ngày tải lên: 11/08/2014, 17:21

... (myopathy, neuropathy, or a combination of the two), is practical because their prognoses differ considerably. Some cases of myopathy appear to be merely ‘membranopathies’, with normal histology and ... Lambert–Eaton (myasthenic) syndrome; MG, myasthenia gravis; NCV, nerve conduction velocity studies; N-M, neuromuscular transmission; SNAPs, sensory nerve action potentials. Modified from Bol...

Ngày tải lên: 12/08/2014, 20:20

... anisotropy are not equal (K x ≠ K y ≠ K z ). As well, K x , K y , K z are typically assumed to be collinear to the x, y, z axes. If it is not possible to align the principal directions of anisotropy ... ng does not hint to any permeability property, but simply means that corneocytes contain pro- teins that can bind water molecules. Moreover, corneocytes are surrounded by a tough...

Ngày tải lên: 13/08/2014, 16:20

... requires cells to be pixels within a lattice ([13] and [43]). Their capacity to quantify cell sorting has been studied using a cell-lattice model where all cells have the same geometry, hypothesis which ... surrounded by an extracellular medium modeled by cells of type τ E . One hundred cells of type τ E were uniformly placed on the frontier of the unit disc . These three types are sim...

Ngày tải lên: 13/08/2014, 16:21

... display, yeast two-hybrid analysis, or any experiment that requires specific antibodies, are difficult or impossible to apply to transmembrane regions of membrane proteins. This makes it hard to ... problem and method. Although it is not yet possible to apply automated methods to provide any desired function, computational design is well suited to identifying combinations of amino...

Ngày tải lên: 14/08/2014, 07:21