Báo cáo y học: "A role for Numb in p53 stabilization" pps

... activity, but instead may be specific for p53. How Numb functions to prevent the ubiquitination of p53 by MDM2 currently remains unclear. It is possible that Numb simply inhibits binding of MDM2 ... but a study published recently in Nature by Colaluca et al. [10] provides an extremely interesting alternative by describing a role for Numb in the regulation of p53 activity...

Ngày tải lên: 14/08/2014, 08:21

Ngày tải lên: 13/08/2014, 01:20

... were incubated in the secondary antibodies for 1 hr at room temperature. Cells were then stained directly with 4 ′,6- diamidino-2-phenylindole, dihydrochloride (DAPI) (Invi- trogen, cat # D1306) for ... were incu- bated with the primary antibody in KB buffer overnight at 4°C. As a control, we used samples incubated in KB buffer with no primary antibody. The primary antibody was the...

Ngày tải lên: 12/08/2014, 01:21

... and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996, 97:2011-2019. 7. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, ... synthesis, but type II collagen synthesis is increased during OA as discussed above.  is discrepancy points to alternative players that are involved in OA. IL-1 might play a role in the...

Ngày tải lên: 12/08/2014, 11:22

... worsened in the clinical course continuously (increasing oxygen requirement, increasing dyspnoe) and died from respiratory failure, while one PAP patient remained clinically stable (P18). The deceased ... flow cytometry (FACSCalibur, Becton-Dickinson, Heidelberg, Germany) as described previously[42]. The following antibodies were used: CD4-allophycocyanine (APC) mouse IgG1, CD8-phycocyanine...

Ngày tải lên: 12/08/2014, 18:22

... antibiotics, prophylactic antibiotics decreased the rate of pancreatic superinfection. This has been studied before, and similar findings were reported by Cinar and colleagues [4]. But in a study by Schwarz ... prophylactic and early therapeutic administration of both meropenem and ciprofloxacin in an animal model. How to translate these findings in clinical practice Although this exper...

Ngày tải lên: 13/08/2014, 11:23

... plumbagin. YgfZ and SodA independently required for resolving plumbagin toxicity Since both ygfZ and sodA were found critical for E. coli to resolve the plumbagin toxicity, we examined whether they ... critical residue in the fingerprint region of YgfZ followed by Figure 2 Different roles played by YgfZ and SodA in counteracting plumbagin. The ΔygfZ and ΔsodA strains were transformed...

Ngày tải lên: 10/08/2014, 05:21

... presynaptic and postsynaptic specializations in the brain, indicating that Agrin has a role, at least in part, in maintaining synaptic structure in this tissue [23]. In addition, Agrin is ... cytokines. These early studies point to an important function for Agrin in Tcell biology and make the case for a more thorough and systematic investigation into its role in t...

Ngày tải lên: 12/08/2014, 12:20

Ngày tải lên: 13/08/2014, 20:22

... Work performed to examine how stress modulates symptoms, especially pain, in other nonautoimmune rheu matic conditions such as fi bromyalgia might also be instructive in elucidating the role of ... relationship between changes in stress-response function and pain and other symptoms probably does not exist. Imaging studies of pain processing in fi bromyalgia indicate that psycho...

Ngày tải lên: 12/08/2014, 14:21