Báo cáo y học: " Human-macaque comparisons illuminate variation in neutral substitution rates" potx

... particularly attractive for investigating local variation in neutral substitution rates, because substitutions can be inferred more reliably than in comparisons with rodents and are less influenced by ... human-rodent comparisons Yes (human, mouse, rat) [38,48] -0.06 -0.22 CTCF-binding sites (P) Predicted CTCF binding sites; identified by single sequence motif finding methods...

Ngày tải lên: 14/08/2014, 08:21

... studies in cystic fibrosis have found tantalizing results in genes involved in infection and inflammation, but many other relevant pathways remain untapped. Genome scanning approaches may eventually ... inherited by the siblings. This coincidence implied that the gene conferring resistance or susceptibility to intesti- nal obstruction in mice is also polymorphic in humans, and that...

Ngày tải lên: 12/08/2014, 18:20

... assem- bled into a panel providing an average of 13 deletions per chromosome [8]. Using this panel, ESTs can be mapped cytologically and physically to one of 159 deletion ‘bins’ (a bin is a region defined ... studies comparing rice-wheat synteny, and it shows significant discontinuity in gene order between rice and wheat as well as the plasticity of cereal genomes. As outlined by Delseny [1...

Ngày tải lên: 09/08/2014, 20:20

... maintain silencing. An early repressive chromatin mark, tri-methylation of lysine 27 on histone H3 (H3K27me3), is recruited by the Polycomb complex of chromatin-modifying proteins, resulting in ... marks, including coating with Xist RNA. is is the earliest event in X inactivation during embryo- genesis, and gene silencing follows within one or two cell cycles [7]. Interestingly, Xis...

Ngày tải lên: 09/08/2014, 20:22

... variance). The X-inactivation process starts at an early stage (approximately at embryonic day 6.5) when there are only a few brain-forming cells, and once X inactivation occurs in a cell, the X inactivation ... compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 2006, 20:1848-1867. 4. Huynh KD, Lee JT: X-chromosome inactivation: a hypothesis linking ontogen...

Ngày tải lên: 09/08/2014, 20:22

... of continuity in the description of the injury. Homer seldom includes a reference to the therapy fol- lowing the inj ury, as in cases 11 and 15. Only in cases of lethal wounds can we infer that ... 54) since they involve Gods. Out of the remaining 50, only 16 or 32% of injuries involve a Trojan perpetrator, while the majority (34 cases or 68%) involves an Achaean one. In terms of grav...

Ngày tải lên: 10/08/2014, 09:22

... agreement. Discussion In this study investigating the reliability of diagnostic coding by physicians trained to collect data in ICU patients, we observed that coding by an external physician after examination ... only data from the ICU stay since stays on other wards are assessed by the ward physi- cians. It includes a principal diagnosis, which plays a central role in the group allocat...

Ngày tải lên: 13/08/2014, 11:22

... (6-11) Y Hugin pyrokinins (1) HUG-PK (8) Y IFamide IFamides (1) IFamide (12) Y Myoinhibiting peptide (MIP) MIPs (5) MIP-1 (9) Y MIP-2 (9) Y MIP-3 (13) Y MIP-4 (11) Y MIP-5 (10) Y Myosuppressin (MS) ... (m/z) % intensity% intensity % intensity % intensity % intensity% intensity % intensity % intensity (cii) (dii) D. virilis D. mojavensis D. pseudoobscura D. sechellia (bii) Geno...

Ngày tải lên: 14/08/2014, 20:22

... this regulation by increasing nuclear membrane availability through increased IPO13 expression or by altering the kinetic properties of GR transport by influencing GR binding affinities. We note ... genotyped variants effectively repre- sent only 6 independent markers for association testing. Associations of IPO13 with airways hyperresponsiveness in CAMP As outlined in the introduction,...

Ngày tải lên: 12/08/2014, 14:20

... Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study. Crit Care 2010, 14:R111. 3. Michard F: Changes in arterial pressure during mechanical ... Takala J: Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study. Crit Care 2010, 14:R122. 2. Wyler vo...

Ngày tải lên: 13/08/2014, 21:21