Báo cáo y học: " ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues" pptx

... R66 Method ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues? Peter Van Loo *†‡ , Stein ... to apply the algorithm to gene sets obtained from clustering microarray data. In nine out of ten microarray clus- ters, ModuleMiner succeeded...

Ngày tải lên: 14/08/2014, 08:21

... activity in TM4 cells. Within this region, four protein-binding sites were detected by DNase I footprinting and gel shift assays. Three of them contained Sp1 cis-acting motifs, which are located ... contain intrinsic protein tyrosine kinase activity in their cytoplasmic regions. They are responsible for transmitting signals from the extracellular environment into the cell cytoplas...

Ngày tải lên: 08/03/2014, 23:20

... impaired sero- tonergic tone induced by 5,7-dihydroxytryptamine reduces the chaotic behavior of the dopaminergic cell-fir- ing pattern while retaining many standard ISI characteris- tics. However, ... stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axes. Hormone and Meta- bolic Research 2005, 37:57 7-5 84. 5. Atchley R...

Ngày tải lên: 13/08/2014, 23:20

... as lower-quality base calls at the ends of the reads and dif- ficulties in identifying splicing between very short exons. Because of the recent improvements in throughput of the next-generation ... possibility of find- ing insertions, deletions, and o ther types of genetic rearrangements with the SplitSeek approach. This moves beyond the scope of RNA-seq data analysis, bec...

Ngày tải lên: 09/08/2014, 20:21

... miRs. Echinoderm Hemichordate Amphioxus Zebrafish X.tropicalis Chicken Mouse Human Ciona mir-1 mir-184 mir-219 mir-375 let-7 mir-182 mir-153 mir-135 mir-133 mir-125 mir-124 mir-10 mir-34 mir-33 mir-31 mir-29 mir-92 mir-9 mir-8 mir-7 mir-216 mir-190 mir-137 mir-99 mir-96 mir-454 mir-367 mir-196 mir-183 mir-132 mir-126 mir-27 mir-15 mir-281 mir-242 Hendrix et al. Genome Biology 2010, 11:R39 htt...

Ngày tải lên: 09/08/2014, 20:21

... new technology, s equencing errors can easily confound ana- lyzes by introducing false polymorphisms and fragment- ing genome assemblies. The Quake system detects and corrects sequencing errors by using ... Elements of Statistical Learning Berlin: Springer; 2009. doi:10.1186/gb-201 0-1 1-1 1-r116 Cite this article as: Kelley et al.: Quake: quality-aware detection and correction...

Ngày tải lên: 09/08/2014, 22:23

... in meningitis-related changes in brain metab- olism, but also to facilitate diagnosis of BM in patients undergoing MD monitoring for the detection of symptomatic vasospasm, and thereby allowing ... complication in patients with SAH, and ICU stay was prolonged by an average of 5.6 days in patients with SAH and BM. The validity of clinical signs and routine CSF analy...

Ngày tải lên: 13/08/2014, 11:23

... 0.86 1 - - - - 0.0656 0.1653 - - VI 820 0 0.04 - - - - - - 0.1043 0.4444 VII 851 - - 0.1733 0.5151 - - 0.5403 0.9128 0.1628 0.5215 VIII 236 - - - - 0.1131 0.5305 - - 0.6427 0.961 IX 462 - - 0.04305 ... not class I 1,882 0.0128 0.1662 - - - - - - - - II 912 0.3996 0.8348 0.8601 0.999 - - 0.360...

Ngày tải lên: 14/08/2014, 07:21

... Przytycka TM: Co-evolutionary analysis of domains in interacting proteins reveals insights into domain-domain interactions mediating protein-protein interactions. J Mol Biol 2006, 362:86 1-8 75. 65. ... explanation of the interac- tion data, roughly speaking: every pair of interacting proteins contains a high-affinity motif pair; non-interacting proteins do not contain such motif pa...

Ngày tải lên: 14/08/2014, 08:20

... skp1-cull-F-box complex; SRS, small ribosomal subunit; Thy-Noc, thymidine-nocodazole synchro- nized cell dataset; Thy-Thy2, thymidine-thymidine synchronized cell dataset 2; Thy-Thy3, thymidine-thymidine synchronized ... of PAK1 [2 9-3 3], 8 are similar to actin or actin-binding proteins, 4 are tubulins or tubulin-related pro- teins, 28 are proteins that localize also to the nucleus...

Ngày tải lên: 14/08/2014, 08:20